Zheng, Jie (郑杰) - University of Texas-Dallas

个人简介

B.S., Inner Mongolian University (1994) Ph.D., Georgia Institute of Technology (2005) Postdoctoral Associate, Harvard University (2005–08)

研究领域

(I) Nano-bio interactions in vivo a. Glomerular filtration of few-atom gold nanoclusters: Size effect b. In vivo transport of renal clearable metal nanoparticles in the kidneys: Margination effect c. Tumor microenvironment: Vasculature and Acidity Effects (II) Biomedical applications of renal clearable metal nanoparticles a. Cancer imaging b.Noninvasive fluorescence kidney functional imaging c. Multimodality in vivo Imaging d. Targeting acidic tumor microenvironment and cancer receptor (III) Nanochemistry and photophysics for luminescent metal nanoparticles

近期论文

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Chuanqi Peng, Jing Xu, Mengxiao Yu, Xuhui Ning, Yingyu Huang, Bujie Du, Elizabeth Hernandez, Payal Kapur, Jer-Tsong Hsieh and Jie Zheng. "Tuning in vivo transport of anticancer drugs with renal-clearable gold nanoparticles." Angew. Chem. Int. Ed. DOI: 10.1002/anie.201903256 (2019). Xingya Jiang, Bujie Du, Shaoheng Tang, and Jer-Tsong Hsieh and Zheng, Jie. "Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution." Angew. Chem. Int. Ed. 2019, 58, 5994 –6000 Yu, Mengxiao, Jing Xu, and Jie Zheng. "Renal Clearable Luminescent Gold Nanoparticles: From the Bench to the Clinic." Angew. Chem. Int. Ed. 2019, 58, 4112 – 4128 Yu, Mengxiao. "How nanotechnology imaging can be used in kidney disease: an interview with Dr Mengxiao Yu." Nanomedicine 12, no. 24 (2018): 3071-3073. Jiang, Xingya, Bujie Du, Yingyu Huang, and Jie Zheng. "Ultrasmall noble metal nanoparticles: Breakthroughs and biomedical implications." Nano Today (2018). Bujie Du, Mengxiao Yu and Jie Zheng. "Transport and Interactions of Nanoparticles in the Kidneys." Nature Reviews Materials. (2018): 1. Shaoheng Tang, and Jie Zheng. "Antibacterial Activity of Silver Nanoparticles: Structural Effects." Advanced healthcare materials (2018): 1701503. Xu, J., Yu, M., Peng, C., Carter, P., Tian, J., Ning, X., Zhou, Q., Tu Qiu., Zhang G., Dao A., Jiang X., Kapur, P., Hsieh, J., Zhao, X., Liu, P., Zheng, J., “Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates.” Angew. Chem. Int. Ed. 2018, 57, 266 –271. Yingyu Huang, Lirit Fuksman, and Jie Zheng. "Luminescence mechanisms of ultrasmall gold nanoparticles" Dalton Transactions 47.18 (2018): 6267-6273. J. Xu, M. Yu, P. Carter A, E. Hernandez, A. Dang, P. Kapur, J. T. Hsieh, J. Zheng. "In Vivo X-ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys", Angew. Chem. Int. Ed., 2017,56,13356–13360 (Highlighted as VIP). Bujie Du, Xingya Jiang, Anindita Das, Qinhan Zhou, Mengxiao Yu, Rongchao Jin, Jie Zheng, "Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometre regime" Nature Nanotechnology, 12, 1096–1102 (2017) Yu, M., Zhou, C., Liu, L., Zhang, S., Sun, S., Hankins, J.D., Sun, X. and Zheng, J., 2017. Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects. Angew. Chem. Int. Ed., 56, pp.4314-4319. Ning, X., Peng, C., Li, E. S., Xu, J., Vinluan, R. D., Yu, M., & Zheng, J. (2017). Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters. APL Materials, 5(5), [053406]. DOI: 10.1063/1.4978381 Xu, J., Peng, C., Yu, M., Zheng, J. Renal clearable noble metal nanoparticles: photoluminescence, elimination, and biomedical applications. WIREs Nanomed Nanobiotechnol 2017. doi: 10.1002/wnan.1453 Peng, C., Gao, X., Xu, J., Du, B., Ning, X., Tang, S., Bachoo, R.M., Yu, M., Ge, W.P. and Zheng, J., 2017. Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles. Nano Research, 4(10), pp.1366-1376. Tang, S., Peng, C., Xu, J., Du, B., Wang, Q., Vinluan, R. D., Yu, M., Kim, M.J., Zheng, J. Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density. Angew. Chem. Int. Ed., 2016, 55, 16039-16043. (Highlighted as VIP) J.B. Liu, P.N. Duchesne, M.X. Yu, X.Y. Jiang, X.H. Ning, P. Zhang, J. Zheng. “Luminescent Gold Nanoparticles with Size-independent Emissions”, Angew. Chem. Int. Ed., 2016. 55, 8894-8898 X.Y. Jiang, B.J. Du, M.X. Yu, X. Jia, J. Zheng. "Surface-Ligand Effect on Radiosensitization of Ultrasmall Luminescent Gold Nanoparticles", J. Innov. Opt. Health. Sci., 9(04), 1642003. S. Sun, X. Ning, G. Zhang, Y.C. Wang, C. Peng, J. Zheng. "Dimerization of Organic Dyes on Luminescent Gold Nanoparticles for Ratiometric pH Sensing", Angew. Chem. Int. Ed., 2016, 55, 2421 –2424. M. X. Yu, J. C. Zhou, B. J. Du, X. H. Ning, C. Authement, L. Gandee, P. Kapur, J. T. Hsieh, J. Zheng. “Noninvasive Staging of Kidney Dysfunction Enabled by Renal Clearable Luminescent Gold Nanoparticles”, Angew. Chem. Int. Ed., 55, 2787-2791 (2016) (Highlighted as VIP).