研究领域

Catalysis/organometallic and organic chemistry: design and development of new transition metal-catalyzed methods that address challenges at the frontiers of organic synthesis.

A central theme of research in our group is the pursuit of green and sustainable methods for the synthesis of fine chemicals, materials, and biologically active compounds using transition metal catalysis. A major focus within this theme is the design and development of catalysts competent to rapidly and selectively functionalize unactivated carbon-oxygen or carbon-hydrogen bonds, which are chemically robust yet ubiquitous in sustainable chemical feedstocks such as lignocellulosic biomass. We are also interested in developing new materials by metal-catalyzed (co)polymerization of simple, renewable monomers with control of the polymer microstructure, molecular weight, and distribution of monomers within the macromolecule. The procurement of a detailed understanding of the structure and reactivity of pertinent catalytic intermediates involved in these processes through mechanistic studies and the application of that knowledge to productively manipulate catalyst function will be an essential element towards realizing our goals.

近期论文

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Carrow, B. P.; Nozaki, K., "Transition-Metal-Catalyzed Functional Polyolefin Synthesis: Effecting Control through Chelating Ancillary Ligand Design and Mechanistic Insights." Macromolecules 2014, 47 (8), 2541-2555. Nakamura, A.; Kageyama, T.; Goto, H.; Carrow, B. P.; Ito, S.; Nozaki, K., "P-Chiral Phosphine-Sulfonate/Palladium-Catalyzed Asymmetric Copolymerization of Vinyl Acetate with Carbon Monoxide." Journal of the American Chemical Society 2012, 134 (30), 12366-12369. Carrow, B. P.; Nozaki, K., "Synthesis of Functional Polyolefins Using Cationic Bisphosphine Monoxide-Palladium Complexes." Journal of the American Chemical Society 2012, 134 (21), 8802-8805. Carrow, B. P.; Hartwig, J. F., "Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions." Journal of the American Chemical Society 2011, 133 (7), 2116-2119. Carrow, B. P.; Hartwig, J. F., "Ligandless, Anionic, Arylpalladium Halide Intermediates in the Heck Reaction." Journal of the American Chemical Society 2010, 132 (1), 79-+. Barrios-Landeros, F.; Carrow, B. P.; Hartwig, J. F., "Effect of Ligand Steric Properties and Halide Identity on the Mechanism for Oxidative Addition of Haloarenes to Trialkylphosphine Pd(0) Complexes." Journal of the American Chemical Society 2009, 131 (23), 8141-8154. Barrios-Landeros, F.; Carrow, B. P.; Hartwig, J. F., "Autocatalytic oxidative addition of PhBr to Pd((PBu3)-Bu-t)(2) via Pd((PBu3)-Bu-t)(2)(H)(Br)." Journal of the American Chemical Society 2008, 130 (18), 5842.​