Tamiya, Shigeo - University of Louisville - Department of Biochemistry and Molecular Genetics

个人简介

Laboratory of Prof. George Duncan, School of Biological Sciences, University of East Anglia, Norwich, UK – 2001-2002; Laboratory of Prof. Nicholas Delamere, Dept of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY – 2002-2005

研究领域

My research is focused on identifying mechanisms involved in fibrotic complications of the eye, and to prevent such fibrosis via pharmacological interventions. Fibrosis is characterized by excessive accumulation and the following contracture of extracellular matrix that lead to tissue deformation and dysfunction. Within the eye, fibrotic complications result in reduced visual acuity and, in severe cases, blindness. My current research focuses on preventing a fibrotic complication termed proliferative vitreoretinopathy (PVR). In PVR, development and subsequent contraction of a fibrotic scar cause the retinal foldings and/or detachment leading to visual impairment. We have established several in vitro models that allow detailed examination of cellular mechanisms associated with PVR such as epithelial-mesenchymal transition and matrix contraction, as well as a swine in vivo model of PVR to test potential therapeutic agents. These in vivo and in vitro models are utilized to achieve the ultimate goal of preventing PVR as well as fibrotic complications/diseases in general.

近期论文

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Tamiya S, Liu L, Kaplan HJ: Epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells initiated upon loss of cell-cell contact. Invest Ophthalmol Vis Sci 2010, 51:2755-63. PMID: 20042656 Umazume K, Barak Y, McDonald K, Liu L, Kaplan HJ, Tamiya S: Proliferative vitreoretinopathy in the Swine-a new model. Invest Ophthalmol Vis Sci 2012, 53:4910-6. PMID: 22729438 Umazume K, Liu L, Scott PA, Fernandez de Castro JP, McDonald K, Kaplan HJ, Tamiya S: Inhibition of PVR with a tyrosine kinase inhibitor, Dasatinib, in the swine. Invest Ophthalmol Vis Sci 2013, 54:1150-9. PMID: 23341014 Umazume K, Tsukahara R, Liu L, Fernandez de Castro JP, McDonald K, Kaplan HJ, Tamiya S: Role of retinal pigment epithelial cell beta-catenin signaling in experimental proliferative vitreoretinopathy. Am J Pathol 2014, 184:1419-28. PMID: 24656918 Tsukahara R, Umazume K, Yamakawa N, McDonald K, Kaplan HJ, Tamiya S: Dasatinib affects focal adhesion and myosin regulation to inhibit matrix contraction by Müller cells. Exp Eye Res 2015, 139:90-6. PMID: 26240967 Tamiya S, Kaplan HJ: Role of epithelial-mesenchymal transition in proliferative vitreoretinopathy. Exp Eye Res 2016, 142:26-31. PMID: 26675400 Liu Y, Ye F, Li Q, Tamiya S, Darling DS, Kaplan HJ, Dean DC: Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology. Invest Ophthalmol Vis Sci 2009, 50(11):5080-8. PMID: 19515996 Tamiya S, Okafor MC, Delamere NA: Purinergic agonists stimulate lens Na-K-ATPase-mediated transport via a Src tyrosine kinase-dependent pathway. Am J Physiol Cell Physiol 2007, 293(2):C790-6. PMID: 17522142 Wormstone IM, Tamiya S, Anderson I, Duncan G: TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci 2002, 43(7):2301-8. PMID: 12091431 Tamiya S, Wormstone IM, Marcantonio JM, Gavrilovic J, Duncan G: Induction of matrix metalloproteinases 2 and 9 following stress to the lens. Exp Eye Res 2000, 71(6):591-7. PMID: 11095911