个人简介
Ph.D.: University of Louisville, Biochemistry and Molecular Biology
Postdoctoral Fellowship: Johns Hopkins University School of Medicine, Pediatric Oncology
研究领域
Dr. Moore’s laboratory focuses on the use of biochemical and developmental programming strategies to investigate the genetic and molecular mechanisms modulating the survival and cardiac reparative properties of adult cardiac progenitor populations (CPCs) residing in the adult mammalian heart. The long term goal of such work is to identify molecular pathways that could be exploited, through genetic modification or pharmacological pretreatment, to enhance the therapeutic efficacy of various autologous cardiac progenitor populations in patients with ischemic cardiac injury. Specific interests include:
1) Pathophysiological and etiological mechanisms of heart failure.
2) Molecular mechanisms underlying cell therapy-mediated cardiac repair.
3) Methods to enhance the cardiac reparative capacity of donor cell populations for cell therapy.
4) Genetic and molecular signaling pathways directing cardiovascular cell lineage commitment and specification.
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Moore IV JB, Zhao J, Fischer AG, Keith MC, Hagan D, Wysoczynski, Boll R. HDAC1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling through a Mechanism Requiring Enhanced bFGF Synthesis and Secretion. JAHA. 2017 May 22. doi: 10.1161/JAHA.117.006183 [In Press]
Wysoczynski M, Guo Y, Moore IV JB, Muthusamy S, Qianhong L, Nasr M, Li H, Nong Y, Wu W, Tomlin AA, Zhu X, Hunt G, Gumpert A, Book MJ, Khan A, Tang XL, and Bolli R. Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence. JACC. 2017 April 11; 69(14):1824-1838. PMID: 28385312
Al-Maqtari T, Hong KU, Vajravelu BN, Moktar A, Cao P, Moore IV JB, and Bolli R. Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells. PLoS One. 2017 March 29; 12(3):e0174242. PMID: 28355297
Amraotkar AR, Song DD, Otero D, Trainor PJ, Ismail I, Kothari V, Singh A, Moore IV JB, Rai SN, and Defilippis AP. Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction. Clinical and Applied Thrombosis/Hemostasis. 2016 Dec 21. PMID: 28294633
Zhao J, Ghafghazi S, Khan AR, Farid TA, and Moore IV JB. Recent Developments in Stem and Progenitor Cell Therapy for Cardiac Repair. Circulation Research. 2016 Dec 9; 119(12):e152-e159. PMID: 27932474
Adamiak M, Abdelbaset-Ismail A, Moore IV JB, Zhao J, Abdel-Latif A, Wysoczynski M, and Ratajczak MZ. Inducible Nitric Oxide Synthase (iNOS) is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking. Stem Cell Rev and Rep. 2016 Oct 16; doi: 10.1007/s12015-016-9693-1 PMID: 27752990
Moore IV JB, Zhao J, Keith MCL, Amraotkar AR, Wysoczynski M, Hong KU, and Bolli R. The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells (CMCs) through a p53-Dependent Mechanism. Stem Cells. 2016 Aug 9. PMID: 27501845
Adamiak M, Moore IV JB, Zhao J, Abdelbaset-Ismail A, Wysoczynski M, and Ratajczak MZ. Downregulation of heme oxygenase-1 (HO-1) activity in hematopoietic cells enhances their engraftment after transplantation. Cell Transplantation. 2015 Oct 16. PMID: 26488466
Vajravelu BN, Hong KU, Al-Maqtari, T, Cao P, Keith MCL, Wysoczynski M, Zhao J, Moore IV JB, and Bolli R. c-Kit Promotes Growth and Migration of Human Cardiac Progenitor cells via the PI3K-AKT and MEK-ERK Pathways. PLOS ONE. 2015 Oct 16;10(10):e0140798. doi: 10.1371/journal.pone.0140798. PMID: 26474484
Keith MC, Tokita Y, Tang XL, Ghafghazi S, Moore IV JB, Hong KU, Elmore JB, Amraotkar AR, Guo H, Ganzel BL, Grubb KJ, Flaherty MP, Vajravelu BN, Wysoczynski M, Bolli R. Effect of the stop-flow technique on cardiac retention of c-kit positive human cardiac stem cells after intracoronary infusion in a porcine model of chronic ischemic cardiomyopathy. Basic Res Cardiol. 2015 Sep; 110(5):503. doi: 10.1007/s00395-015-0503-8. Epub 2015 Jul 7. PMID: 26150250
Keith MC, Tang XL, Tokita Y, Li QH, Ghafghazi S, Moore IV JB, Hong KU, Elmore B, Amraotkar A, Ganzel BL, Grubb KJ, Flaherty MP, Hunt G, Vajravelu B, Wysoczynski M, and Bolli R. Safety of intracoronary infusion of 20 million C-kit positive human cardiac stem cells in pigs. PLOS ONE. 2015 Apr 23; 10(4):e0124227. doi: 10.1371/journal.pone.0124227 PMID: 25905721
Moore IV JB, Loeb DM, Hong KU, Sorenson PH, Triche TJ, Lee WD, Barbato MI, and Arceci RJ. Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line. Front. Cell Dev. Biol.2015 Mar 9.doi: 10.3389/fcell.2015.00015 PMID: 25806369
Ghafghazi S, Wysoczynski M, Keith MC, Moore IV JB, and Bolli R. Ventricular remodeling: the appropriate surrogate end point for cell-based therapy?Dialogues Cardiovasc Med.2015 Jan;20(2):126-138 PMID: N/A
Flaherty MP?, Mohsen A?, Moore IV JB, Schneibel E, Rawasia W, Williams ML, Grubb, KJ, and Hirsch GA: Predictors and Clinical Impact of Preexisting and Acquired Thrombocytopenia Following Transcatheter Aortic Valve Replacement. Catheterization & Cardiovascular Interventions. 2014 Sep 10. doi: 10.1002/ccd.25668 ?Co-first authors PMID: 25204308
Wysoczynski M, Hong KU, and Moore IV JB: Bone Marrow Cell Therapies in Ischemic Cardiomyopathy. Expert Opinion on Biological Therapy. 2014 Sep; 14(9):1229-32. doi: 10.1517/14712598.2014.925873. Epub 2014 Jun 4. PMID: 24897618
Hong KU and Moore IV JB: Recent Advances in Cardiac Myocyte Biology and Function. Circulation Research. 2013 Dec 6; 113(12):e121-4. doi: 10.1161/CIRCRESAHA.113.302990. Epub 2013 Dec 6. PMID: 24311621
Henson AL, Moore IV JB, Alard P, Liu JM, Ellis SR: Mitochondrial function is impaired in yeast and human cellular models of Shwachman Diamond syndrome. Biochem Biophys Res Commun. 2013 Jul 19; 437(1):29-34. doi:10.1016/j.bbrc.2013.06.028. Epub 2013 Jun 19. PMID: 23792098
Moore IV JB, Farrar JE, Arceci RJ, Liu JM, and Ellis SR: Distinct Ribosome Maturation Defects in Yeast Models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome. Haematologica. 2010; 95:57-64. doi:10.3324/haematol.2009.012450 PMID: 19713223
京公网安备 11010802027423号