Hoyle, Gary - University of Louisville - Department of Biochemistry and Molecular Genetics

个人简介

Dr. Hoyle received a B.A. from Johns Hopkins University in 1982 and a Ph.D. in Biochemistry from Duke University in 1988. He engaged in postdoctoral training at the University of Pennsylvania from 1988-1993 and joined the faculty of Tulane University in the Pulmonary Section of the Department of Medicine in 1993. Dr. Hoyle joined the department of Environmental and Occupational Health Sciences at the University of Louisville in 2007. Dr. Hoyle’s research interests are focused on understanding how inhaled agents that are encountered in the environment or in occupational settings injure the lung and how the lung is repaired after injury. An understanding of mechanisms underlying lung injury and repair has the potential to lead to novel treatments for pulmonary disorders. Dr. Hoyle has studied mechanisms of lung injury induced by a variety of inhaled agents, including chlorine, ozone, isocyanates, asbestos, silica, bleomycin, allergens, cigarette smoke, and ambient particulate matter.

近期论文

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Musah, S., DeJarnett, N., and Hoyle, G. W. (2012). Tumor necrosis factor-a mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter. Toxicol. 299:125-132. http://www.sciencedirect.com/science/article/pii/S0300483X12001709 Chang, W., Chen, J., Schlueter, C. F., Rando, R. J., Pathak, Y. V., and Hoyle, G. W. (2012). Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram. Toxicol. Appl. Pharmacol. 263:251-258. PMC3422440. http://www.sciencedirect.com/science/article/pii/S0041008X12002761 Musah, S., Chen, J., and Hoyle, G. W. (2012). Repair of tracheal epithelium by basal cells after chlorine-induced injury. Respir. Res. 13:107. PMC3544626. http://respiratory-research.com/content/13/1/107 Mo, Y., Chen, J., Schlueter, C. F., and Hoyle, G. W. (2013). Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 304:L92-L102. PMC3543638. http://ajplung.physiology.org/content/304/2/L92.long Chen, J., Mo, Y., Schlueter, C. F., and Hoyle, G. W. (2013). Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol. Appl. Pharmacol. 272:408-413. PMC4005342. http://www.sciencedirect.com/science/article/pii/S0041008X13002822 Mo, Y., Chen, J., Humphrey, D. M. Jr., Fodah, R. A., Warawa, J. M., and Hoyle, G. W. (2015). Abnormal epithelial structure and chronic lung inflammation after repair of chlorine-induced airway injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 308:L168-L178. PMC4338946. http://ajplung.physiology.org/content/308/2/L168 Satpathy, S. R., Jala, V. R., Bodduluri, S. R., Krishnan, E., Hegde, B., Hoyle, G. W., Fraig, M., Luster, A. D., and Haribabu, B. (2015). Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumor growth. Nat. Commun. 6:7064. PMC4418220. http://www.nature.com/ncomms/2015/150429/ncomms8064/full/ncomms8064.html Hoyle , G. W., Chen, J., Schlueter, C. F., Mo, Y., Humphrey, D. M. Jr., Rawson, G., Ni?o, J. A., and Carson, K. H. (2016). Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation. Toxicol. Appl. Pharmacol. 298:9-18. PMC4821717. http://www.sciencedirect.com/science/article/pii/S0041008X16300473 Hoyle, G. W., and Svendsen, E. R. (2016). Persistent effects of chlorine inhalation on respiratory health. Ann. N. Y. Acad. Sci. 1378:33-40. http://onlinelibrary.wiley.com/doi/10.1111/nyas.13139/full Musah, S., Schlueter, C. F., Humphrey, D. M. Jr., Powell, K. S., Roberts, A. M., and Hoyle G.W. (2017). Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation. Toxicol. Appl. Pharmacol. 315:1-11. http://www.sciencedirect.com/science/article/pii/S0041008X16303726 Conklin, D. J., Haberzettl, P., Jagatheesan, G., Kong, M., and Hoyle, G. W. (2017). Role of TRPA1 in acute cardioplumonary toxicity of inhaled acrolein. Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2016.08.028. http://www.sciencedirect.com/science/article/pii/S0041008X16302514