个人简介

B.S., Wisconsin State University (1967): Chemistry PhD, Kansas State University (1971): Physical/Inorganic Chemistry NIH Postdoctoral Associate, New Mexico State University (1971–72)

研究领域

Cecil H. and Ida Green Distinguished Chair in Systems Biology, Professor of Chemistry Director, Advanced Imaging Research Center, UT Southwestern MRI contrast agents; biomedical NMR

Our chemistry group at UT Dallas is involved in the design of novel MR imaging agents that respond to physiology and metabolism, including targeted Gd3+-based agents that respond to binding events in vivo and paramagnetic CEST agents that offer multi-color imaging of metabolic events and that can be turned off and on by application of a radiofrequency pulse. Other active areas of research include biomedical magnetic resonance techniques, applications of 13C and 2H NMR to studies of intermediary metabolism in animals and humans, in vivo spectroscopy in human tissues.

近期论文

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“A Multislice Gradient Echo Pulse Sequence for CEST Imaging”, WT Dixon, I Hancu, SJ Ratnaker, AD Sherry, RE Lenkinski & DC Alsop, Magn. Reson. Med., 63, 253–256 (2010). "A Concentration-Independent Method to Measure Exchange Rates in PARACEST Agents", WT Dixon, J Ren, AJM Lubag, J Ratnakar, E Vinogradov, I Hancu, RE Lenkinski & AD Sherry, Magn. Reson. Med., 63, 625-632 (2010). “Advantages of Macromolecular to Nanosized Chemical-exchange Saturation Transfer Agents for MRI Applications”, Y Wu, M Evbuomwan, M Melendez, A Opina & AD Sherry, Future Medicinal Chemistry, 2, 351-366 (2010). “Alternatives to Gadolinium-based MRI Metal Chelates for Magnetic Resonance Imaging”, S. Viswanathan, Z. Kovacs, SJ Ratnakar, KN Green & AD Sherry, Chem. Rev., 110, 2960-3018 (2010). “Improved Synthesis of DOTA-Tetraamide Ligands for Lanthanide(III) ions: A Tool for Increasing the Repertoire of Potential PARACEST Contrast Agents for MRI and/or Fluorescent Sensors”, LM DeLeon-Rodriguez, S Viswanathan & AD Sherry, Contrast Media & Mol. Imaging, 5, 121-125 (2010). “Activation of a PARACEST Agent for MRI through Selective Outer-sphere Interactions with Phosphate Diesters”, C-H Huang, J Hammell, SJ Ratnakar, AD Sherry & JR Morrow, Inorg. Chem., 49, 5963-5970 (2010). “CEST and PARACEST MR Contrast Agents”, I Hancu, WT Dixon, M Woods, E Vinogradov, AD Sherry & RE Lenkinski, Acta Radiologica, 51, 910-923 (2010). "Multifunctional Polymeric Scaffolds for Enhancement of PARACEST Contrast Sensitivity and Performance: The Effects of Random Copolymer Variations" Y Wu, P Zhao, G Kiefer & AD Sherry, Macromolecules, 43, 6616-6624 (2010). “The Population of SAP and TSAP Isomers in Cyclen-Based Lanthanide(III) Chelates is Substantially Affected by Solvent”, KJ Miller, AA Saherwala, B Webber, Y Wu, AD Sherry & M Woods, Inorg. Chem., 49, 8662-8664 (2010). “Polymeric PARACEST MRI Contrast Agents as Potential Reporters for Gene Therapy”, Y Wu, C Carney, M Denton, E Hart, P Zhao, DN Streblow, AD Sherry & M Woods, Org. Biomol. Chem., 8, 5333-5338 (2010). “Strategies for Labeling Proteins with PARACEST Agents”, O Vasalatiy, P Zhao, M Woods, A Marconescu, A Castillo-Muzquiz, P Thorpe, GE Kiefer & AD Sherry, Bioorg & Med. Chem., 19, 1106-1114 (2011). “Europium(III) DOTA-derivatives having Ketone Donor Pendant Arms Display Dramatically Slower Water Exchange”, KN Green, S Viswanathan, FA Rojas-Quijano, Z Kovacs & AD Sherry, Inorg. Chem., 50, 1648-1655 (2011). “A Lanthanide Complex with Dual Biosensing Properties: CEST (Chemical Exchange Saturation Transfer) and BIRDS (Biosensor Imaging of Redundant Deviation in Shifts) with Europium DOTA-Tetraglycinate-“, D Coman, GE Kiefer, DL Rothman, AD Sherry & F Hyder, NMR in Biomed., 24, 1216-1225 (2011). “Investigations into Whole Water, Prototropic and Amide Proton Exchange in Lanthanide(III) DOTA-Tetraamide Chelates”, M Woods, A Pasha, G Tircso, S Chowdhury, G Kiefer, DE Woessner and AD Sherry, Dalton Trans., 40, 6759-6764 (2011). “On-Bead Combinatorial Synthesis and Imaging of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Agents To Identify Factors That Influence Water Exchange”, R Napolitano, TC Soesbe, L DeLeon-Rodriguez, AD Sherry, & D. Gomika Udugamasooriya, J. Amer. Chem. Soc., 133, 13023-13030 (2011). “The pH Sensitivity of –NH Exchange in LnDOTA-tetraamide Complexes Varies with Amide Substituent”, ACL Opina, Y Wu, P Zhao, GE Kiefer & AD Sherry, Contrast Media Mol Imaging, 6: 459-64 (2011). “TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive lipoCEST agents”, ACL Opina, KB Ghaghada, P Zhao, GE Kiefer, A Annapragada & AD Sherry, PLoS One 6: e27370. (2011). “Towards the Rational Design of MRI Contrast Agents: ?-Substitution of Lanthanide(III) NB-DOTA-Tetraamide Chelates Influences but Does Not Control Coordination Geometry”, CE Carney, AD Tran, J Wang, MC Schabel, AD Sherry & M Woods, Chem. Eur. J., 17, 10372-10378 (2011). “Nanoparticle-based PARACEST agents: The quenching effect of silica nanoparticles on the CEST signal from surface conjugated chelates”, OM Evbuomwan, ME Merritt, GE Kiefer & AD Sherry, Contrast Media & Mol. Imaging, 7, 19-25 (2012). “Amphiphilic EuDOTA-tetraamide complexes form micelles with enhanced CEST sensitivity”, OM Evbuomwan, GE Kiefer & AD Sherry, J. Biol. Inorg. Chem., 2012, 2126-2134.