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个人简介

Education Experience: 1983-1988 B.Sc. Chemistry Leiden University 1984-1986 M.S. Western philosophy Leiden University 1990-1994 Ph. D. Organic Chemistry Leiden University Professional Experience: 2016- Distinguished Perennial Guest Professor Tianjin University 1996-1997 NWO Talent Postdoc Columbia University 1997-2006 Assistant and Associate Professor Wageningen University 2007- Personal Chair in Organic Chemistry Wageningen University 2008-2016 Chair of Organic Chemistry Wageningen University 2011-2016 Distinguished Adjunct Professor of Chemical and Ma King Abdulaziz University Honors and Awards: 2014 – present: Perennial Distinguished Guest Professor, Tianjin University, Tianjin, China. 2013 – 2014: Joseph Meyerhoff Visiting Professor, Weizmann Institute, Rehovot, Israel. 2011 – present: Distinguished Adjunct Professor, King Abdulaziz University, Jeddah, Saudi Arabia. Spring 2007: Visiting Professor at Stanford University, Stanford, California, USA. Oct. 2005: Visiting Professor to Lanzhou University, Lanzhou, China. Summer 2003: Visiting Fellow to the National Canadian Nanotechnology Institute, Ottawa, Canada. Fall 2002: Emerson Visiting Research Fellow at Emory University, Atlanta, Georgia, USA. 1994 – 1995: Postdoctoral Talent Fellowship (NWO). 1994: L. J. Oosterhoff Award (L. J. Oosterhoff Fund, administered by Leiden University). 1988 – 1989: Netherlands Ramsay Memorial Fellowship (Royal Netherlands Academy of Sciences).

研究领域

I am interest in the development of surface-bound organic chemistry, meaning organic reactions taking place at or near the confinement of a surface. This involves the synthesis of tailor-made molecules, the development and use of analytical methods to study such modified surfaces, and the use of experimental and theoretical (quantum-chemical) methods to quantitatively understand this. This interest has recently expanded to both the (site selective) modification of protein surfaces and single polymer studies.

近期论文

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High Rates of Quinone-Alkyne Cycloaddition Reactions are Dictated by Entropic Factors ChemRxiv 2023 | Other DOI: 10.26434/chemrxiv-2023-2ndds EID: 2-s2.0-85148983429 Part of ISSN: 25732293 CONTRIBUTORS: Damen, J.A.M.; Escorihuela, J.; Zuilhof, H.; van Delft, F.; Albada, B. Bifunctional Ti4+-modified paper for selective extraction or removal of phospholipids and paper spray mass spectrometry for bioanalysis in urine and plasma Analytica Chimica Acta 2023-10 | Journal article DOI: 10.1016/j.aca.2023.341673 CONTRIBUTORS: Wei Luo; Teris A. van Beek; Bo Chen; Han Zuilhof; Gert IJ. Salentijn SI-PET-RAFT in flow: improved control over polymer brush growth Polymer Chemistry 2023 | Journal article DOI: 10.1039/D3PY00488K CONTRIBUTORS: Andriy R. Kuzmyn; Martijn van Galen; Barend van Lagen; Han Zuilhof DFT Study of Imine‐Exchange Reactions in Iron(II)‐Coordinated Pincers Chemistry – A European Journal 2023-11-02 | Journal article DOI: 10.1002/chem.202301795 CONTRIBUTORS: Annemieke van Dam; Robin van Schendel; Satesh Gangarapu; Han Zuilhof; Maarten M. J. Smulders Toward the Rational Design of More Efficient Mo2C Catalysts for Hydrodeoxygenation–Mechanism and Descriptor Identification ACS Catalysis 2023-10-20 | Journal article DOI: 10.1021/acscatal.3c03728 CONTRIBUTORS: Raghavendra Meena; Johannes Hendrik Bitter; Han Zuilhof; Guanna Li Tunable Supramolecular Ag+-Host Interactions in Pillar[n]arene[m]quinones and Ensuing Specific Binding to 1-Alkynes Molecules 2023-10-10 | Journal article DOI: 10.3390/molecules28207009 CONTRIBUTORS: Yumei Zhu; Jorge Escorihuela; Haiying Wang; Andrew C.-H. Sue; Han Zuilhof Internal hydrogen bonding of imines to control and enhance the dynamic mechanical properties of covalent adaptable networks European Polymer Journal 2023-08 | Journal article DOI: 10.1016/j.eurpolymj.2023.112209 CONTRIBUTORS: Sybren K. Schoustra; Vahid Asadi; Han Zuilhof; Maarten M.J. Smulders Enantiospecific Synthesis of Aniline-Derived Sulfonimidamides Organic Letters 2023-08-04 | Journal article DOI: 10.1021/acs.orglett.3c02132 CONTRIBUTORS: Dong-Dong Liang; Natassa Lional; Bas Scheepmaker; Muthusamy Subramaniam; Guanna Li; Fedor M. Miloserdov; Han Zuilhof Sulfur fluoride exchange Nature Reviews Methods Primers 2023-08-03 | Journal article DOI: 10.1038/s43586-023-00241-y CONTRIBUTORS: Joshua A. Homer; Long Xu; Namitharan Kayambu; Qinheng Zheng; Eun Joung Choi; Byeong Moon Kim; K. Barry Sharpless; Han Zuilhof; Jiajia Dong; John E. Moses High Rates of Quinone‐Alkyne Cycloaddition Reactions are Dictated by Entropic Factors Chemistry – A European Journal 2023-07-11 | Journal article DOI: 10.1002/chem.202300231 CONTRIBUTORS: Johannes A. M. Damen; Jorge Escorihuela; Han Zuilhof; Floris L. van Delft; Bauke Albada Modular Design for Proteins Assembling into Antifouling Coatings: Case of Gold Surfaces Langmuir 2023-07-11 | Journal article DOI: 10.1021/acs.langmuir.3c00389 CONTRIBUTORS: Chuanbao Zheng; Nicolò Alvisi; Robbert Jan de Haas; Zhisen Zhang; Han Zuilhof; Renko de Vries 19 nm‐Thick Grafted‐To Polymer Brushes onto Optimized Poly(Dopamine)‐Coated Surfaces Advanced Materials Interfaces 2023-06 | Journal article DOI: 10.1002/admi.202202503 CONTRIBUTORS: Lucas W. Teunissen; Maarten M. J. Smulders; Han Zuilhof Correction to “Toward Improving Triplet Energy Transfer from Tetracene to Silicon Using a Covalently Bound Tetracene Seed Layer” The Journal of Physical Chemistry Letters 2023-06-15 | Journal article DOI: 10.1021/acs.jpclett.3c01487 CONTRIBUTORS: Alyssa F. J. van den Boom; Silvia Ferro; María C. Gelvez-Rueda; Han Zuilhof; Bruno Ehrler Modular and Substrate-Independent Grafting-To Procedure for Functional Polymer Coatings Langmuir 2023-06-06 | Journal article DOI: 10.1021/acs.langmuir.3c00280 CONTRIBUTORS: Lucas W. Teunissen; Maarten M. J. Smulders; Han Zuilhof Toward Improving Triplet Energy Transfer from Tetracene to Silicon Using a Covalently Bound Tetracene Seed Layer The Journal of Physical Chemistry Letters 2023-05-18 | Journal article DOI: 10.1021/acs.jpclett.3c00589 CONTRIBUTORS: Alyssa F. J. van den Boom; Silvia Ferro; María Gelvez-Rueda; Han Zuilhof; Bruno Ehrler Correction to “Sulfur-Phenolate Exchange as a Mild, Fast, and High-Yielding Method toward the Synthesis of Sulfonamides” Organic Letters 2023-03-03 | Journal article DOI: 10.1021/acs.orglett.3c00361 CONTRIBUTORS: Alyssa F. J. van den Boom; Han Zuilhof Sulfur-Phenolate Exchange as a Mild, Fast, and High-Yielding Method toward the Synthesis of Sulfonamides Organic Letters 2023-02-10 | Journal article DOI: 10.1021/acs.orglett.2c04292 CONTRIBUTORS: Alyssa F. J. van den Boom; Han Zuilhof Biointerfaces and Biopolymers Macromolecular Bioscience 2022 | Journal article DOI: 10.1002/mabi.202200439 EID: 2-s2.0-85141715913 Part of ISSN: 16165195 16165187 CONTRIBUTORS: Rodriguez-Emmenegger, C.; Zuilhof, H. Calibrating catalytic DNA nanostructures for site-selective protein modification ChemRxiv 2022 | Other DOI: 10.26434/chemrxiv-2022-kbglv EID: 2-s2.0-85128849464 Part of ISSN: 25732293 CONTRIBUTORS: Keijzer, J.F.; Zuilhof, H.; Albada, B. Crown ether-modified polyelectrolytes and their interactions with cations – A QCM study Applied Surface Science Advances 2022 | Journal article DOI: 10.1016/j.apsadv.2022.100271 EID: 2-s2.0-85135881945 Part of ISSN: 26665239 CONTRIBUTORS: Sahin, S.; van Weeren, E.; Zuilhof, H.; de Smet, L.C.P.M. Degradable click-reaction-based polymers as highly functional materials Matter 2022 | Journal article DOI: 10.1016/j.matt.2022.06.033 EID: 2-s2.0-85135534646 Part of ISSN: 25902385 25902393 CONTRIBUTORS: Subramaniam, M.; Ruggeri, F.S.; Zuilhof, H. Enhanced monovalent over divalent cation selectivity with polyelectrolyte multilayers in membrane capacitive deionization via optimization of operational conditions Desalination 2022 | Journal article DOI: 10.1016/j.desal.2021.115391 EID: 2-s2.0-85122521147 Part of ISSN: 00119164 CONTRIBUTORS: Sahin, S.; Zuilhof, H.; Zornitta, R.L.; de Smet, L.C.P.M. Recent progress in the structural study of ion channels as insecticide targets Insect Science 2022 | Journal article DOI: 10.1111/1744-7917.13032 EID: 2-s2.0-85132615512 Part of ISSN: 17447917 16729609 CONTRIBUTORS: Hadiatullah, H.; Zhang, Y.; Samurkas, A.; Xie, Y.; Sundarraj, R.; Zuilhof, H.; Qiao, J.; Yuchi, Z. Ryanodine Receptor as Insecticide Target Current Pharmaceutical Design 2022 | Journal article DOI: 10.2174/1381612827666210902150224 EID: 2-s2.0-85122241522 Part of ISSN: 18734286 13816128 CONTRIBUTORS: Samurkas, A.; Yao, L.; Hadiatullah, H.; Ma, R.; Xie, Y.; Sundarraj, R.; Zuilhof, H.; Yuchi, Z. Synthesis of well-defined linear–bottlebrush–linear triblock copolymer towards architecturally-tunable soft materials Polymer Chemistry 2022 | Journal article DOI: 10.1039/D2PY00841F CONTRIBUTORS: Vahid Asadi; Xuecong Li; Francesco Simone Ruggeri; Han Zuilhof; Jasper van der Gucht; Thomas E. Kodger Twisted pentagonal prisms: AgnL2 metal-organic pillars Chem 2022 | Journal article DOI: 10.1016/j.chempr.2022.04.001 EID: 2-s2.0-85129245455 Part of ISSN: 24519294 24519308 CONTRIBUTORS: Wan, X.; Li, S.; Tian, Y.; Xu, J.; Shen, L.-C.; Zuilhof, H.; Zhang, M.; Sue, A.C.-H. Boronate affinity paper spray mass spectrometry for determination of elevated levels of catecholamines in urine Analytica Chimica Acta 2022-12 | Journal article DOI: 10.1016/j.aca.2022.340508 CONTRIBUTORS: Wei Luo; Teris A. van Beek; Bo Chen; Han Zuilhof; Gert IJ. Salentijn Sulfur-Phenolate Exchange As a Fluorine-Free Approach to S(VI) Exchange Chemistry on Sulfonyl Moieties Organic Letters 2022-12-02 | Journal article DOI: 10.1021/acs.orglett.2c03421 CONTRIBUTORS: Alyssa F.J. van den Boom; Muthusamy Subramaniam; Han Zuilhof Biointerfaces and Biopolymers Advanced Materials Interfaces 2022-11 | Journal article DOI: 10.1002/admi.202202252 CONTRIBUTORS: Cesar Rodriguez‐Emmenegger; Han Zuilhof Thermoresponsive Polymer Brushes for Switchable Protein Adsorption via Dopamine‐Assisted Grafting‐To Strategy Advanced Materials Interfaces 2022-11 | Journal article DOI: 10.1002/admi.202201198 CONTRIBUTORS: Lucas W. Teunissen; Jelle van den Beukel; Maarten M. J. Smulders; Han Zuilhof Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating ACS Omega 2022-11-01 | Journal article DOI: 10.1021/acsomega.2c03214 CONTRIBUTORS: Andriy R. Kuzmyn; Lucas W. Teunissen; Michiel V. Kroese; Jet Kant; Sandra Venema; Han Zuilhof Semiquantitative Screening of THC Analogues by Silica Gel TLC with an Ag(I) Retention Zone and Chromogenic Smartphone Detection Analytical Chemistry 2022-10-11 | Journal article DOI: 10.1021/acs.analchem.2c01627 CONTRIBUTORS: Si Huang; Ruiying Qiu; Zhengfa Fang; Ke Min; Teris A. van Beek; Ming Ma; Bo Chen; Han Zuilhof; Gert IJ. Salentijn Calibrating Catalytic DNA Nanostructures for Site‐Selective Protein Modification** Chemistry – A European Journal 2022-09-12 | Journal article DOI: 10.1002/chem.202200895 CONTRIBUTORS: Jordi F. Keijzer; Han Zuilhof; Bauke Albada Sulfur–Phenolate Exchange: SuFEx‐Derived Dynamic Covalent Reactions and Degradation of SuFEx Polymers Angewandte Chemie International Edition 2022-09-05 | Journal article DOI: 10.1002/anie.202207456 CONTRIBUTORS: Yang Chao; Akash Krishna; Muthusamy Subramaniam; Dong‐Dong Liang; Sidharam P. Pujari; Andrew C.‐H. Sue; Guanna Li; Fedor M. Miloserdov; Han Zuilhof “Rim‐Differentiated” Pillar[6]arenes Angewandte Chemie International Edition 2022-08 | Journal article DOI: 10.1002/anie.202204589 CONTRIBUTORS: Yang Chao; Tushar Ulhas Thikekar; Wangjian Fang; Rong Chang; Jiong Xu; Nianfeng Ouyang; Jun Xu; Yan Gao; Minjie Guo; Han Zuilhof et al. PUFA-Derived N-Acylethanolamide Probes Identify Peroxiredoxins and Small GTPases as Molecular Targets in LPS-Stimulated RAW264.7 Macrophages ACS Chemical Biology 2022-08-19 | Journal article DOI: 10.1021/acschembio.1c00355 CONTRIBUTORS: Ian-Arris de Bus; Antoine H. P. America; Norbert C. A. de Ruijter; Milena Lam; Jasper W. van de Sande; Mieke Poland; Renger F. Witkamp; Han Zuilhof; Michiel G. J. Balvers; Bauke Albada Synthetic Strategy towards a Carbocyclic N‐Acetylneuraminic Acid European Journal of Organic Chemistry 2022-07-21 | Journal article DOI: 10.1002/ejoc.202200297 CONTRIBUTORS: Pieter de Saint Aulaire; Jorin Hoogenboom; Michiel T. Uiterweerd; Han Zuilhof; Tom Wennekes Binding S(VI) to alkynes Nature Synthesis 2022-05-30 | Journal article DOI: 10.1038/s44160-022-00081-w CONTRIBUTORS: Fedor Miloserdov; Han Zuilhof Highly Specific Protein Identification by Immunoprecipitation–Mass Spectrometry Using Antifouling Microbeads ACS Applied Materials & Interfaces 2022-05-25 | Journal article DOI: 10.1021/acsami.1c22734 CONTRIBUTORS: Esther van Andel; Mark Roosjen; Stef van der Zanden; Stefanie C. Lange; Dolf Weijers; Maarten M. J. Smulders; Huub F. J. Savelkoul; Han Zuilhof; Edwin J. Tijhaar Self-healing antifouling polymer brushes: Effects of degree of fluorination Applied Surface Science 2022-03 | Journal article DOI: 10.1016/j.apsusc.2021.152264 CONTRIBUTORS: Annemieke van Dam; Maarten M.J. Smulders; Han Zuilhof Thermoresponsive, Pyrrolidone‐Based Antifouling Polymer Brushes Advanced Materials Interfaces 2022-02 | Journal article DOI: 10.1002/admi.202101717 CONTRIBUTORS: Lucas W. Teunissen; Andriy R. Kuzmyn; Francesco S. Ruggeri; Maarten M. J. Smulders; Han Zuilhof Configurationally Chiral SuFEx‐Based Polymers Angewandte Chemie 2022-02-14 | Journal article DOI: 10.1002/ange.202116158 CONTRIBUTORS: Dong‐Dong Liang; Sidharam P. Pujari; Muthusamy Subramaniam; Maarten Besten; Han Zuilhof Frontispiece: Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices Angewandte Chemie International Edition 2022-02-14 | Journal article DOI: 10.1002/anie.202280861 CONTRIBUTORS: Anna Lisa Semrau; Philip M. Stanley; Dominik Huber; Michael Schuster; Bauke Albada; Han Zuilhof; Mirza Cokoja; Roland A. Fischer Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices Angewandte Chemie International Edition 2022-02-14 | Journal article DOI: 10.1002/anie.202115100 CONTRIBUTORS: Anna Lisa Semrau; Philip M. Stanley; Dominik Huber; Michael Schuster; Bauke Albada; Han Zuilhof; Mirza Cokoja; Roland A. Fischer Diblock and Random Antifouling Bioactive Polymer Brushes on Gold Surfaces by Visible‐Light‐Induced Polymerization (SI‐PET‐RAFT) in Water Advanced Materials Interfaces 2022-01 | Journal article DOI: 10.1002/admi.202101784 CONTRIBUTORS: Andriy R. Kuzmyn; Lucas W. Teunissen; Pina Fritz; Barend van Lagen; Maarten M. J. Smulders; Han Zuilhof Antibiotic-Like Activity of Atomic Layer Boron Nitride for Combating Resistant Bacteria ACS Nano 2021 | Journal article DOI: 10.1021/acsnano.1c11353 EID: 2-s2.0-85130030435 Part of ISSN: 1936086X 19360851 CONTRIBUTORS: Pan, Y.; Zheng, H.; Li, G.; Li, Y.; Jiang, J.; Chen, J.; Xie, Q.; Wu, D.; Ma, R.; Liu, X. et al. Ionization of glycans from alkali metal salt-impregnated paper Talanta 2021 | Journal article DOI: 10.1016/j.talanta.2021.122674 EID: 2-s2.0-85109431926 Part of ISSN: 00399140 CONTRIBUTORS: Guo, P.; Min, K.; Luo, W.; Huang, S.; Yang, Z.; Ma, M.; Liu, S.; Fang, Z.; Chen, B.; Zuilhof, H. Molecular control over vitrimer-like mechanics – tuneable dynamic motifs based on the Hammett equation in polyimine materials Chemical Science 2021 | Journal article DOI: 10.1039/D0SC05458E CONTRIBUTORS: Sybren K. Schoustra; Joshua A. Dijksman; Han Zuilhof; Maarten M. J. Smulders

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