个人简介
Education Experience：
2003-2008 Ph. D. Organic Chemistry Nankai Univ
1999-2003 Bachelor of Science Chemistry Nankai Univ
Professional Experience：
2009-2014 Postdoc University of California, Berkeley
2014-2016 Ass Project Scientist University of California, Berkeley
2016- Associate Prof Tianjin Univ
研究领域
Our group research interest lies in investigating basic mechanism of bio-active molecular (including nitric oxide, hydride and methyl et al.) transfer reaction in enzyme or in solution, with a goal of 1) design of more efficient chemical catalysis as well as the designed enzyme; 2) rational design of corresponding inhibitor/drug basing on the mechanism exploration. This inspiring research area requires the combination the application of physical organic chemistry, biochemistry, chemical biology and molecular biology. The most recently work refers to the understanding the role of compaction in methyl transfer reactions with the target of finding how the molecular motion in enzymes would affect the catalytic ability in the methyl transfer reaction. This study about the methyl transfer system had/will extended from catechol-O-methyltransferase (COMT) to glycine-N-methyltransferase (GNMT), Nicotinamide N-Methyltransferase (NNMT) and DNA\RNA demethylation with various experimental approaches such kinetic isotope effect, binding isotope effect, time-resolved spectrometers, hydrogen deuterium exchange with mass spectrometry (HDX-MS) as well as computational simulation.
近期论文
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Kinetic isotope effect study of N-6 methyladenosine chemical demethylation in bicarbonate-activated peroxide system
Li Fangya,Wang Ying,Zhang Jianyu
J. Chem. Phys. 159, 124103 (2023)
https://doi.org/10.1063/5.0169285
Comprehensive Understanding of the Kinetic Behaviors of Main Protease from SARS-CoV-2 and SARS-CoV: New Data and Comparison to Published Parameters
Molecules
2023-06-07 | Journal article
DOI: 10.3390/molecules28124605
Part of ISSN: 1420-3049
CONTRIBUTORS: Fangya Li; Tingting Fang; Feng Guo; Zipeng Zhao; Jianyu Zhang
Wang, X., Li, F. & Zhang, J. Theoretical prediction for redox potentials of oxygen-centered organic anions in aprotic solvents. Theor Chem Acc 142, 62 (2023). https://doi.org/10.1007/s00214-023-03002-y
Single-stranded RNA as primers of terminal deoxynucleotidyl transferase for template-independent DNA polymerization
Chinese Chemical Letters
2023-02 | Journal article
DOI: 10.1016/j.cclet.2022.05.047
Part of ISSN: 1001-8417
CONTRIBUTORS: Houyu Han; Jingyu Cui; Dianming Zhou; Deping Hua; Weipan Peng; Mengyao Lin; Yating Zhang; Fangya Li; Xiaoqun Gong; Jianyu Zhang
Binding Affinity Studies of Nicotinamide N-methyltransferase and Ligands by Saturation Transfer Difference NMR
Tingting Fang, Jianyu Zhang
Protein Pept Lett，2023;30(9):734-742. doi: 10.2174/0929866530666230824153356
Predicting the Mechanism of Demethylation of Nucleobases in Theoretical Simulation: A Review
Guo Feng,Wang Ying,Zhang Jianyu
Published:2023-04-21
Container-title:2023 11th International Conference on Bioinformatics and Computational Biology (ICBCB)
Deuterium Solvent Kinetic Isotope Effect on Enzymatic Methyl Transfer Catalyzed by Catechol O-methyltransferase
Zipeng Zhao,Fangya Li,Jianyu Zhang
Page:351-359 ISSN:0929-8665 2023
Container-title:Protein & Peptide Letters
Theoretical Study of O-CH3 Bond Dissociation Enthalpy in Anisole Systems
Li Rui,Du Tianshu,Liu Jingxing,Aquino Adelia J. A.,Zhang Jianyu
Page:21952-21959 ISSN:2470-1343 2021
Container-title:ACS Omega
Linkage of nanosecond protein motion with enzymatic methyl transfer by nicotinamide N-methyltransferase.
Turkish journal of biology = Turk biyoloji dergisi
2021-06 | Journal article
DOI: 10.3906/biy-2101-54
PMID: 34377057
PMC: PMC8313939
CONTRIBUTORS: Jing Y; Cheng Y; Li F; Li Y; Liu F; Zhang J
Solvent inhibition profiles and inverse solvent isotope effects for enzymatic methyl transfer catalyzed by nicotinamide N ‐methyltransferase
Journal of Physical Organic Chemistry
2020-06-30 | Journal article
DOI: 10.1002/poc.4093
Nano-second Protein Dynamics of Key Residue at Position 38 in Catechol-O-Methyltransferase System: A Time-resolved Fluorescence Study
The Journal of Biochemistry
2020-06-03 | Journal article
DOI: 10.1093/jb/mvaa063
Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction
Proceedings of the National Academy of Sciences
2020-05-19 | Journal article
DOI: 10.1073/pnas.1917219117
Theoretical O–CH3 bond dissociation enthalpies of selected aromatic and non-aromatic molecules
Theoretical Chemistry Accounts
2020-04 | Journal article
DOI: 10.1007/s00214-020-02592-1
Activity-Related Microsecond Dynamics Revealed by Temperature-Jump Förster Resonance Energy Transfer Measurements on Thermophilic Alcohol Dehydrogenase.
Journal of the American Chemical Society
2018-01-11 | Journal article
DOI: 10.1021/jacs.7b12369
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