Youcai, Zhang - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 2011 Ph. D. Pharmacology and Toxicology University of Kansas Medical Center 2013-2014 Postdoctoral Bioengineering University of California San Francisco Professional Experience： 2011-2013 Associate Scientist Elan Pharmaceutics Inc 2013-2014 Principle Scientist Apricity Therapeutics Honors and Awards： Associate Editor, Toxicological Sciences Editor board member, Journal of Lipid Research

研究领域

3) establishment of novel preclinical models to improve the prediction of drug-induced liver injury 2) investigation of the role of intestinal microbiota in lipid metabolism; 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases;

近期论文

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Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine Yajuan Bi , Yanchao Xing , Chunshan Gui , Yiqing Tian , Mingzhe Zhang , Yao Yao , Ge Hu , Lifeng Han , Feng He , Youcai Zhang Planta Med 2023; 89(10): 940-951 DOI: 10.1055/a-2085-2367 Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays Phytomedicine 2023-04 | Journal article DOI: 10.1016/j.phymed.2023.154710 CONTRIBUTORS: Yanchao Xing; Qiao Yu; Lin Zhou; Wen Cai; Yuxin Zhang; Yajuan Bi; Youcai Zhang; Zhifei Fu; Lifeng Han Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation Journal of Natural Products 2023-01-27 | Journal article DOI: 10.1021/acs.jnatprod.2c00927 CONTRIBUTORS: Yajuan Bi; Xue Wang; Lifeng Han; Yiqing Tian; Tongwei Bo; Caiyu Li; Bowen Shi; Chunshan Gui; Youcai Zhang Transporter-mediated Natural Product-Drug Interactions Yajuan Bi , Xue Wang , Hui Ding , Feng He , Lifeng Han , Youcai Zhang Planta Med 2023; 89(02): 119-133 DOI: 10.1055/a-1803-1744 Shunaoxin dropping pill improves cognitive functions of rats with chronic cerebral hypoperfusion via the microbiota-gut-brain axis Bo Tongwei,Cai Wen,Sun Peinan,Zhang Tong,Gao Peng,Han Jing,Jin Leixin,Zhang Mingzhe,Bi Yajuan,Xu Tong,Li Huixiang,Tian Yiqing,Zhang Shuang,Wang Jiajun,Zhang Youcai Page:148158 ISSN:0006-8993 2023 Container-title:Brain Research 3D-QSAR analysis of the interactions of flavonoids with human organic cation transporter 2 Bi Yajuan,Wang Xue,Li Huixiang,Tian Yiqing,Han Lifeng,Gui Chunshan,Zhang Youcai Page:1-8 ISSN:0378-4274 2022 Container-title:Toxicology Letters Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity Hui Xiong, Chunze Zhang, Lifeng Han, Tong Xu, Khawar Saeed, Jing Han, Jing Liu, Curtis D. Klaassen, Frank J. Gonzalez, Yuanfu Lu, Youcai Zhang First published: 06 December 2021 https://doi.org/10.1002/hep.32270 Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2 Wang Guangju,Bi Yajuan,Xiong Hui,Bo Tongwei,Han Lifeng,Zhou Lijun,Zhang Chunze,Zhang Youcai Page:S447-S459 ISSN:0960-3271 2021 Container-title:Human & Experimental Toxicology Yinzhihuang Oral Liquid Ameliorates Hyperbilirubinemia Induced by δ-Aminolevulinic Acid and Novobiocin in Neonatal Rats Jing Han, Caiyu Li, Zhi Dai, Juanhui Duan, Wen Cai, Yong Wang, Youcai Zhang First published: 03 June 2021 https://doi.org/10.1002/cbdv.202100222 Inhibition of Arterial Thrombus Formation by Blocking Exposed Collagen Surface Using LWWNSYY-Poly(l-Glutamic Acid) Nanoconjugate Langmuir 2021-06-08 | Journal article DOI: 10.1021/acs.langmuir.1c00894 CONTRIBUTORS: Na Sun; Zhao Ye; Tanyi Hao; Si Zheng; Yan Sun; Youcai Zhang; Lin Zhang Pharmacokinetic studies unveiled the drug–drug interaction between trans-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix Journal of Pharmaceutical and Biomedical Analysis 2019-02 | Journal article DOI: 10.1016/j.jpba.2018.11.034 Part of ISSN: 0731-7085 CONTRIBUTORS: Yanchao Xing; Linlin Wang; Chenxi Wang; Youcai Zhang; Yi Zhang; Limin Hu; Xiumei Gao; Lifeng Han; Wenzhi Yang Validated UPLC‐MS/MS method for quantification of seven compounds in rat plasma and tissues: Application to pharmacokinetic and tissue distribution studies in rats after oral administration of extract of Eclipta prostrata L. Biomedical Chromatography 2018-06 | Journal article DOI: 10.1002/bmc.4191 CONTRIBUTORS: Guangyan Du; Lingling Fu; Jun Jia; Xu Pang; Haiyang Yu; Youcai Zhang; Guanwei Fan; Xiumei Gao; Lifeng Han