Yuchi, Michael - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 2003-2009 Ph. D. Biochemistry and Biomedical Sciences McMaster University 1999-2003 B.Sc. Life Sciences Fudan University Professional Experience： 2021- Professor Tianjin University 2016-2021 Associate Professor Tianjin Univeristy 2010-2016 Research Associate Univeristy of British Columbia 2009-2010 Postdoctoral Fellow Cold Spring Harbor Laboratory Honors and Awards： NSFC Excellent Young Scientist 2020 Tianjin 1000-talent Scholar 2017 Peiyang Scholar 2016 Michael John Page Award 2014 Michael Smith Award 2013

研究领域

The research of Yuchi’s group centers on the structure and function of ion channels. Ion channels are the second largest target class for approved drugs. Drugs targeting ion channels are used to treat arrhythmia, neuropathic pain, epilepsy, anxiety and more. The ultimate goal of our group is to understand the physiological and pathological roles of ion channels at the molecular level. The specific questions we are tackling include: 1) the interaction network and regulation of ion channels involved in heart and muscle diseases; 2) how disease-causing mutations perturb the structure and function of critical ion channels; 3) how to target insect ion channels to develop novel biopesticides. To answer these questions, our lab combines a variety of complementary techniques, including X-ray crystallography, electrophysiology, calorimetry, in-silico drug screening, as well as many other biochemical, biophysical and computational methods.

近期论文

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Chen W., Cao P., Liu Y., Yu A., Wang D., Chen L., Sundarraj R., Yuchi Z., Gong Y.*, Merzendorfer H.*, Yang Q.* (2022) Structural basis for directional chitin biosynthesis. Nature, doi: 10.1038/s41586-022-05244-5. Qin, J., Zhang, J., Lin, L., Haji-Ghassemi, O., Lin, Z., Woycechowsky, K.J., Van Petegem, F., Zhang, Y.*, Yuchi, Z.* (2022) Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. eLife, doi: 10.7554/eLife.75346. Duan Y., Wei Y., Xing M., Liu J., Jiang L., Lu Q., Liu X., Liu Y., Ang EL., Liao RZ., Yuchi Z.*, Zhao H.*, Zhang Y.* (2022) Anaerobic Hydroxproline Degradation Involving C-N Cleavage by a Glycyl Radical Enzyme. J Am Chem Soc, doi: 10.1021/jacs.2c01673. Hadiatullah, H., Zhang, Y., Samurkas, A., Xie, Y., Sundarraj, R., Zuilhof, H., Qiao, J.*, Yuchi, Z.* (2022) Recent progress in the structural study of ion channels as insecticide targets. Insect Science, doi: 10.1111/1744-7917.13032. Jia, Z., Liu, C., Chen, Y., Jiang, H., Wang, Z., Yao, J., Yang, J., Zhu, J., Zhang, B., Yuchi, Z. (2021) Crystal structures of the SARS-CoV-2 nucleocapsid protein C-terminal domain and development of nucleocapsid-targeting nanobodies. FEBS J, doi: 10.1111/febs.16239. Samurkas, A., Yao, L., Hadiatullah, H., Ma, R., Xie, Y., Sundarraj, R., Zuilhof, H., Yuchi, Z. (2021) Ryanodine receptor as insecticide target. Curr Pharm Design. doi: 10.2174/1381612827666210902150224. Lu, Q.#, Wei, Y.#, Lin, L., Liu, J., Duan, Y., Li, Y., Zhai, W., Liu, Y., Ang, E., Zhao, H.*, Yuchi, Z.*, Zhang, Y.* (2021) The Glycyl Radical Enzyme Arylacetate Decarboxylase from Olsenella scatoligenes. ACS Catalysis, doi: 10.1021/acscatal.1c01253 Ma, R.#, Haji-Ghassemi, O.#, Ma, D.#, Jiang, H.#, Lin, L., Yao, L., Samurkas, A., Li, Y., Wang, Y., Cao, P., Wu, S., Zhang, Y., Murayama, T., Moussian, B., Van Petegem, F.*,Yuchi, Z.* (2020) Structural Basis for Diamide Modulation of Ryanodine Receptor. Nature Chemical Biology, doi: 10.1038/s41589-020-0627-5 Zhou, Y.#, Wang, W.#, Salauddin, N., You, M.,You, S.*,Yuchi, Z.* (2020) Crystal structure of the N-terminal domain of ryanodine receptor from the honeybee, Apis mellifera. Insect Biochemistry and Molecular Biology, doi: 10.1016/j.ibmb.2020.103454 Liu, J.#, Wei, Y., Lin, L., Teng, L., Yin, J., Lu, Q., Chen, J., Zheng, Y., Li, Y., Xu, R., Zhai, W., Liu, Y., Liu, Y., Cao, P., Ang, E., Zhao, H.*, Yuchi, Z.*,Zhang, Y.* (2020) Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate. Proc.Nati.Acad. Sci., doi: 10.1073/pnas.2003434117 Samurkas, A., Fan, X., Ma, D., Sundarraj, R., Lin, L., Yao, L., Ma, R., Jiang, H., Cao, P., Gao, Q., and Yuchi, Z. (2020) Discovery of potential species-specific green insecticides targeting lepidopteran ryanodine receptor. Journal of Agricultural and Food Chemistry, doi: 10.1021/acs.jafc.0c01063 You, M.*, Ke,F.#, You,S.#, Wu, Z.#, Liu, Q.#, He, W.#, Baxter, S.#, Yuchi, Z.#, Vasseur, L.*, Gurr, G.*, Ward, C., Cerda, H., Yang, G., Peng, L., Jin, Y., Xie, M., Cai, L., Douglas, C., Isman, M., Goettel, M., Song, Q., Fan, Q., Wang-Pruski, G., Lees, D., Yue, Z.*, Bai, J., Liu, Y., Lin, L., Zheng, Y., Zeng, Z., Lin, S., Wang, Y., Zhao,Q., Xia, X., Chen, W., Chen, L., Zou, M., Liao, J., Gao, Q., Fang, X., Yin, Y., Yang, H., Wang, J., Han, L., Lin, Y., Lu, Y., and Zhuang, M. (2020) Variation among 532 genomes unveils the origin and evolutionary history of a global insect herbivore. Nature Communications, doi: 10.1038/s41467-020-16178-9 Xu., T., and Yuchi, Z. (2019) Crystal structure of diamondback moth ryanodine receptor Repeat34 domain reveals insect-specific phosphorylation sites. BMC Biology, doi: 10.1186/s12915-019-0698-5 Lin, L., Hao, Z., Cao, P, and Yuchi, Z. (2019) Homology modeling and docking study of diamondback moth ryanodine receptor reveals the mechanisms for channel activation, insecticide binding and resistance. Pest Management Science, doi: 10.1002/ps.5640 Haji-Ghassemi, O., Yuchi, Z., and Van Petegem, F. (2019) The Cardiac Ryanodine Receptor Phosphorylation Hot Spot Embraces PKA in a Phosphorylation-Dependent Manner. Molecular Cell., pii: S1097-2765(19)30311-9 Xing, M., Wei, Y., Zhou, Y., Zhang, J., Lin, L., Hu, Y., Hua, G., Nanja, A., Liu, D., Wang, F., Guo, C., Tong, Y., Li, M., Liu, Y., Ang, EL., Zhao, H.*, Yuchi, Z.*, and Zhang, Y.* (2019) Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nature Communications., 10:1609 Lin, L., Liu, C., Nayak, BC., He, W., You, M.*, and Yuchi, Z*. (2018) A two-step purification strategy using calmodulin as an affinity tag. J Chromatogr A., 1544, 16-22 Lin, L., Liu, C., Qin, J., Wang, J., Dong, S., Chen, W., He, W., Gao, Q., You, M.*, and Yuchi, Z.* (2018) Crystal structure of ryanodine receptor N-terminal domain from Plutella xylostella reveals two potential species-specific insecticide-targeting sites. Insect Biochem Mol Biol, 92, 73-83