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个人简介

教育经历: 2010.10 - 2012.8 宾西法尼亚大学 - 材料学 - 公派留学 2007.1 - 2012.1 天津大学 - 材料学 - 硕博联读 2003.9 - 2007.7 天津大学 - 材料学 - 学士 工作经历: 2020.6 - 今 生命科学学院 → 天津大学 → 教授 2015.9 - 2020.5 生命科学学院 → 天津大学 → 副教授 2014.9 - 2015.9 生命科学学院 → 天津大学 → 讲师 2013.6 - 2014.9 材料学院 → 天津大学 → 讲师 2012.8 - 2013.9 工学院 → 新加坡国立大学 → 博士后 获奖及相关成果: 2022年,生物工程学报思政教改论文:“强基计划”背景下生物学实验教学改革 2022年,获评“中国颗粒学会青年颗粒学奖”(国家一级学会奖) 2022年,获评天津市“创新创业教育特色示范课程” 2021年,获国家自然科学基金委“国家优秀青年基金”资助 2019年,获评天津大学“北洋学者计划—青年学者”荣誉称号 2018年,入选首批天津市“青年人才托举工程” 2018年,获评天津市创新人才推进计划“青年科技优秀人才”荣誉称号 2016年,获评天津大学“青年教工示范岗”荣誉称号

研究领域

生物应用(肠道健康、脑健康、肿瘤预防、病毒防治) 生物技术(光遗传调控、生物图像检测、工程益生菌群、稀土生物成像) 生物材料(生物颗粒、生物膜材料、生物多糖、生物活材料)

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Meihui Cui, Huaqing Yang, Binglin Ma, Shenjunjie Lu, Dawei Sun, Minye Yang, Kang Peng, Shufang Zhang, Jing Liu, Peiyuan Liu*, Hanjie Wang*. A smartphone-based inverse opal hydrogel film aptasensor for mycotoxin detection by the naked eye. Microchemical Journal, 2023, 194, 109234.(亮点:将光子晶体与智能手机图像处理相结合,用于真菌毒素检测,祝贺崔梅慧!) Minghui Zhang, Yingying Zhang, Pengcheng Zhao, Hanjie Wang*. Construction of “lock-key” biological living material based on double engineered bacteria and its application on intestinal retention in vivo. Chinese Journal of Biotechnology, 2023, 39(3), 1163-1174.(亮点:利用特异性分子,调控工程菌组装,祝贺张明慧!) Ya Li, Xinyu Liu, Yingying Zhang, Ziyue Wu, Wei Ling, Xinyu Zhang, Mingxing Zhou, M. Serdar Onses, Pan Zhou, Sui Mao, Wenxing Huo, Zhenzhen Fan, Hong Yang, Hanjie Wang*, Xian Huang*. A flexible wearable device coupled with injectable Fe3O4 nanoparticles for capturing circulating tumor cells and triggering their deaths. Biosensors and Bioelectronics, 2023, 235, 115367. Qiwen Bao, Gang Li, Zhengchun Yang, Jun Liu, Hanjie Wang, Gaoju Pang, Qianjin Guo, Jun Wei, Wenbo Cheng, Ling Lin. Electrochemical biosensor based on antibody‑modifed Au nanoparticles for rapid and sensitive analysis of infuenza A virus. Ionics, 2023, 29, 2021-2029. Yingying Zhang, Ruru Kang, Xinyu Zhang, Gaoju Pang, Lianyue Li, Chunli Han, Baona Liu, Xin Xue, Jing Liu, Tao Sun, Tao Wang, Peiyuan Liu*, Hanjie Wang*. A programmable oral bacterial hydrogel for controllable production and release of nanovaccine for tumor immunotherapy. Biomaterials, 2023, 299, 122147.(亮点:利用合成生物学设计工程菌,基于群感信号调控其释放颗粒药物,祝贺张英英、康如如!) Lianyue Li, Chun Yang, Jing Liu, Yiyang Pan, Xuyan Wang, Yiliang Zhang, Hanjie Wang*, Tao Sun*, Duo Liu*. Hydrogel-Encapsulated Engineered Microbial Consortiumasa Photoautotrophic " Living Material " for Promoting Skin Wound Healing. ACS Applied Materials & Interfaces, 2023, 15, 5, 6536–6547.(亮点:利用合成生物学,设计光自养工程化菌群,用于表皮伤口修复研究,祝贺李连月、杨淳!) Xinyu Zhang, Gaoju Pang, Tao Sun, Xinyu Liu, Huizhuo Pan, Yingying Zhang, Jing Liu, Jin Chang*, Hanjie Wang*, Duo Liu*. A red light-controlled probiotic bio-system for in-situ gut-brain axis regulation. Biomaterials, 2023, 294, 122005.(亮点:利用红光基因元件,设计构建红光响应的光遗传工程菌,用于肠脑轴脑疾病调控研究,祝贺张新宇!) Yingying Zhang, Xin Xue, Mingxi Fang, Gaoju Pang, Yujuan Xing, Xinyu Zhang, Lianyue Li, Qu Chen, Yuxin Wang, Jin Chang, Peiqi Zhao*, Hanjie Wang*. Upconversion Optogenetic Engineered Bacteria System for Time-Resolved Imaging Diagnosis and Light-Controlled Cancer Therapy. ACS Applied Materials & Interfaces, 2022, 14 (11) , 46351−46361.(亮点:将稀土时间分辨成像和光遗传工程菌相结合,构建肿瘤一体化诊疗纳米系统,祝贺张英英、薛鑫!) Xinyu Zhang, Ning Ma, Wei Ling, Gaoju Pang, Tao Sun, Jing Liu, Huizhuo Pan, Meihui Cui, Chunli Han, Chun Yang, Jin Chang, Xian Huang*, Hanjie Wang*. A micro-nano optogenetic system based on probiotics for in situ host metabolism regulation. Nano Research, 2022, doi.org/10.1007/s12274-022-4963-5.(亮点:利用光遗传学工程菌,对血糖异常大鼠模型进行血糖调控研究,祝贺张新宇、马宁!) Meihui Cui, Wei Ling, Lili Zhang, Yayang Li, Jing Liu, Tao Sun, Binglin Ma, Shenjunjie Lu, Huizhuo Pan, Gaoju Pang, Yingying Zhang, Shufang Zhang, Xian Huang, Peiqi Zhao, Duo Liu*, Hanjie Wang* . Smartphone bioelectronic drug with visual colorimetric sensor and bulknanoencapsulation optogenetic bacteria for chronic kidney disease theragnostics. Chemical Engineering Journal, 2023, 451, 138812.(亮点:利用光成像检测技术和光遗传学工程菌,构建生物电子药用于肾病诊疗,祝贺崔梅慧、张立立!) Shenjunjie Lu, Binglin Ma, Haoran Zhou, Yayang Li, Zhihao Qiao, Tong Xiao, Husheng Li, Baijie Wang, Meihui Cui, Shufang Zhang, Jin Chang, Taofeng Du*, Jing Liu*, Hanjie Wang* . Smartphone recognition-based immune microparticles for rapid on-site visual data-sharing detection of Newcastle disease virus. Talanta, 2023, 252, 123845.(亮点:基于手机图像检测技术,建立新城疫病毒快速检测方法,祝贺陆沈焌杰、马炳林两位本科生!) Bing Chen, Meihui Cui, Yuan Wang, Peng Shi*, Hanjie Wang* and Feng Wang*. Recent advances in cellular optogenetics for photomedicine. Advanced Drug Delivery Reviews, 2022, 188 , 114457.(亮点:合作文章,综述了触发光遗传学的诸多给光方法,祝贺崔梅慧!) Changsong Wu, Meihui Cui, Li Cai, Chen Chen, Xiaohui Zhu, Yihan Wu, Jinliang Liu*, Hanjie Wang* and Yong Zhang*.NIR-Responsive Photodynamic Nanosystem Combined with Antitumor Immune Optogenetics Bacteria for Precise Synergetic Therapy. ACS Applied Materials & Interfaces, 2022, 14 (11) , 13094-13106.(亮点:合作文章,光动力结合光遗传工程菌用于抗肿瘤,祝贺崔梅慧!) Chunli Han, Xinyu Zhang, Gaoju Pang, Yingying Zhang, Huizhuo Pan, Lianyue Li, Meihui Cui, Baona Liu, Ruru Kang, Xin Xue, Tao Sun, Jing Liu, Jin Chang, Peiqi Zhao and Hanjie Wang*. Hydrogel microcapsules containing engineered bacteria for sustained production and release of protein drugs. Biomaterials, 2022, 287, 121619.(亮点:构建工程菌活药进行皮下给药,探索其作为肿瘤疫苗功效,祝贺韩春丽!) Huizhuo Pan, Tao Sun, Meihui Cui, Ning Ma, Chun Yang, Jing Liu, Gaoju Pang, Baona Liu, Lianyue Li, Xinyu Zhang, Weiwen Zhang, Jin Chang and Hanjie Wang*. Light-Sensitive Lactococcus lactis for Microbe−Gut−Brain Axis Regulating via Upconversion Optogenetic Micro-Nano System. ACS Nano, 2022, 16(4), 6049–6063.(亮点:构建光遗传工程菌,用于肠脑轴调控研究,祝贺潘惠卓!) Lianyue Li, Huizhuo Pan, Gaoju Pang, Haoyu Lang, Yue Shen, Tao Sun, Yingying Zhang, Jing Liu, Jin Chang, Jun Kang*, Hao Zheng* and Hanjie Wang*. Precise Thermal Regulation of Engineered Bacteria Secretion for Breast Cancer Treatment In Vivo. ACS Synthetic Biology, 2022, 11(3), 1167-1177.(亮点:利用热遗传技术,构建工程菌生物活药系统,祝贺李连月!) Yingying Zhang, Tiange Wang, Yu Tian, Chaonan Zhang, Kun Ge, Jinchao Zhang, Jin Chang* and Hanjie Wang*. Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence. Acta Pharmaceutica Sinica B, 2021, 11 (7), 1978-1992.(亮点:利用纳米药物载体材料,构建肿瘤术后免疫诊疗系统,祝贺张英英!) Yu Tian, Yingying Zhang, Xinyu Zhang, Huizhuo Pan, Lili Zhang, Shuang Liu, Yulan Chen, Lin Su, Peiqi Zhao*, Jin Chang* and Hanjie Wang*. "Magnetism-Optogenetic" System for Wireless and Highly Sensitive Neuromodulation. Advanced Healthcare Materials, 2021, 2102023.(亮点:利用商品化稀土应力发光材料,构建光遗传通用型光触发器件,祝贺田雨!) Yingying Zhang, Tiange Wang, Yinping Zhuang, Tiandi He, Xiaoli Wu, Lin Su, Jun Kang*, Jin Chang*, Hanjie Wang*. Sodium Alginate Hydrogel-Mediated Cancer Immunotherapy for Postoperative In Situ Recurrence and Metastasis. ACS biomaterials science & engineering, 2021, 7(12), 5717-5726. (亮点:利用纳米免疫疗法,用于防治术后肿瘤复发研究,祝贺张英英、王天歌!) Xinyu Zhang,Yingying Zhang,Chaonan Zhang,Chun Yang,Ran Tian,Tao Sun,Weiwen Zhang,Jin Chang*,Hanjie Wang*. An injectable hydrogel co-loading with cyanobacteria and upconversion nanoparticles for enhanced photodynamic tumor therapy. Colloids and Surfaces B: Biointerfaces, 2021, 111640. (亮点:将蓝细菌与稀土材料结合,提升光动力抗肿瘤效应,祝贺张新宇、张英英、张超楠!) Huizhuo Pan, Lianyue Li, Gaoju Pang, Chunli Han, Baona Liu, Yingying Zhang, Yue Shen, Tao Sun, Jing Liu, Jin Chang, Hanjie Wang*. Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy. Chemical Engineering Journal, 2021, 426, 130842. (亮点:构建稀土光遗传工程菌,用于抗肿瘤研究,祝贺潘惠卓!) Gaoju Pang, Yingying Zhang, Xiaoyong Wang, Huizhuo Pan, Xinyu Zhang,Yayang Li, Shufang Zhang, Chunhua Yan*, Lingdong Sun*, Hanjie Wang* and Jin Chang*. In vivo high-contrast visualization of upconversion nanoparticle labeled virus using time-resolved approach. Nano Today, 2021, 40, 101264. (亮点:利用稀土纳米探针标记活病毒,体内外可视化研究病毒侵染过程,祝贺庞高举!) Meihui Cui, Tao Sun, Shubin Li, Huizhuo Pan, Jing Liu, Xinyu Zhang, Lianyue Li, Shanshan Li, Chunyang Wei, Chengzhuang Yu, Chun Yang, Ning Ma, Binglin Ma, Shenjunjie Lu, Jin Chang, Weiwen Zhang and Hanjie Wang*. NIR light-responsive bacteria with live bio-glue coatings for precise colonization in the gut. Cell Reports, 2021, 36, 109690. (亮点:构建光遗传工程菌,用于提供菌株肠道定植效率,祝贺崔梅慧!) Lili Zhang, Ziyu Zhang, Yu Tian, Meihui Cui, Beibei Huang, Tao Luo*, Shufang Zhang* and Hanjie Wang*. Rapid, simultaneous detection of mycotoxins with smartphone recognition-based immune microspheres. Analytical and Bioanalytical Chemistry, 2021, 413 (14), 3683-3693. (亮点:利用手机图像处理功能,实现毒素快速检测,祝贺张立立!) Jiahua Li, Yafeng Hao,Huizhuo Pan, Yingying Zhang, Guohui Cheng, Baona Liu, Jin Chang and Hanjie Wang*. CRISPR-dcas9 Optogenetic Nanosystem for the Blue Light-Mediated Treatment of Neovascular Lesions. ACS Applied Biomaterials, 2021, 4(3), 2502-2513. (亮点:利用稀土光遗传技术,用于治疗视网膜病变研究,祝贺李佳桦!) Jingxian Yu, Wei Ling, Ya Li, Ning Ma, Ziyue Wu, Rong Liang, Huizhuo Pan, Wentao Liu, Bo Fu, Kun Wang, Chenxi Li, Hanjie Wang, Hui Peng, Baoan Ning, Jiajia Yang, and Xian Huang*. A Multichannel Flexible Optoelectronic Fiber Device for Distributed Implantable Neurological Stimulation and Monitoring. Small, 2021, 17 (4). Jun Kang, Ayesha Tahir, Hnajie Wang and Jin Chang*. Applications of nanotechnology in virus detection, tracking, and infection mechanisms. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2021, 13 (4). Meihui Cui, Gaoju Pang, Tao Zhang, Tao Sun, Lili Zhang, Ruru Kang, Xin Xue, Huizhuo Pan, Chun Yang, Xinyu Zhang, Jin Chang, Jing Liu*, Shufang Zhang* and Hanjie Wang*. Optotheranostic Nanosystem with Phone Visual Diagnosis and Optogenetic Microbial Therapy for Ulcerative Colitis At-Home Care. ACS Nano, 2021, 15(4), 7040-7052. (亮点:利用光遗传工程菌分泌药物,治疗肠道炎症研究,祝贺崔梅慧!) Tiandi He, HanJie Wang*, Tiange Wang, GaoJu Pang, YingYing Zhang, Chaonan Zhang, Peng Yu and Jin Chang*. Sonogenetic nanosystem activated mechanosensitive ion channel to induce cell apoptosis for cancer immunotherapy. Chemical Engineering Journal, 2021, 44, 127173. (亮点:利用声遗传学技术,进行肿瘤免疫治疗研究,祝贺何天地!) Jingxian Yu, Wei Ling, Ya Li, Ning Ma, Ziyue Wu, Rong Liang, Huizhuo Pan, Wentao Liu, Bo Fu, Kun Wang, Chenxi Li, Hanjie Wang, Hui Peng, Baoan Ning, Jiajia Yang and Xian Huang*. A Multichannel Flexible Optoelectronic Fiber Device for Distributed Implantable Neurological Stimulation and Monitoring. Small, 2020, 2005925. Tiange Wang, Hanjie Wang*, Gaoju Pang, Tiandi He, Peng Yu, Guohui Cheng, Yingying Zhang,and Jin Chang*. A Logic AND-Gated Sonogene Nanosystem for Precisely Regulating the Apoptosis of Tumor Cells. ACS Applied Materials & interfaces, 2020, 12(51), 56692-56700. (亮点:利用声遗传学技术,进行肿瘤治疗研究,祝贺王天歌!) Yingying Zhang, Xin Zhang, Hanjie Wang*, Yu Tian, Huizhuo Pan, Lili Zhang, Feng Wang* and Jin Chang*. Remote Regulation of Optogenetic Proteins by a Magneto‐Luminescence Microdevice. Advanced Functional Materials, 2020, 2006357. (亮点:将磁致形变与稀土应力发光相结合,用于无创细胞光遗传刺激调控,祝贺张英英!) Junxiao Gao, Jun Li, Daohe Wei, Han Yang, Yue Duan, Yue Zhang, Xiaoqun Gong, Hanjie Wang, Dan Ding, Xiaoli Wu* and Jin Chang*. Enabling AIEgens close assembly in tumor-overexpressed protein cluster for boosted image-guided cancer surgery. Science China-Chemistry. 2020, 63 (11), 1694-1702. Lu Li, Shenghui Li, Sheng Wang, Xiaoli Xing, Yating Zhang, Lin Sud, Xiaoli Wu, Hanjie Wang, Jin Chang* and Xiaoqun Gong*. Antioxidant and anti-glycated TAT-modified platinum nanoclusters as eye drops for non-invasive and painless relief of diabetic cataract in rats. Chemical Engineering Journal, 2020, 398, 125436. Chun Yang, Meihui Cui, Yingying Zhang, Huizhuo Pan, Jing Liu, Shixing Wang, Ning Ma, Jin Chang, Tao Sun* and Hanjie Wang*. Upconversion optogenetic micro-nanosystem optically controls the secretion of light-responsive bacteria for systemic immunity regulation. Communications Biology, 2020, 3(1),561. (亮点:构建光遗传肠道工程菌,用于肠道炎症及肿瘤治疗,祝贺杨淳!) Ran Tian, Zhaosong Wang, Ruifang Niu, Hanjie Wang*, Weijiang Guan* and Jin Chang*. Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy. Frontiers in Bioengineering and Biotechnology, 2020, 8, 1010. (亮点:构建类脂质纳米载体,用于化疗/光热协同肿瘤治疗,祝贺田然!) Yafeng Hao, Taofeng Du, Gaoju Pang, Jiahua Li, Huizhuo Pan, Yingying Zhang, Lizhen Wang, Jin Chang, En-min Zhou* and Hanjie Wang*. Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem. Nano Research, 2020, 13(12), ‏3253-3260. (亮点:利用光遗传技术,调控蛋白泛素化降解过程用于抗病毒,祝贺郝亚锋!) Wei Ling, Jingxian Yu, Ning Ma, Ya Li, Ziyue Wu, Rong Liang, Yafeng Hao, Huizhuo Pan, Wentao Liu, Bo Fu, Kun Wang, Hanjie Wang, Lizhu Li, Xing Sheng, Hui Peng, Baoan Ning, Jiajia Yang and Xian Huang*. Flexible Electronics and Materials for Synchronized Stimulation and Monitoring in Multi-Encephalic Regions. Advanced Functional Materials, 2020, 30(32), 2002644. Guohui Cheng, Hanjie Wang*, Chaonan Zhang, Yafeng Hao, Tiange Wang, Yingying Zhang, Yu Tian and Jin Chang*. Multifunctional nano-photosensitizer: A carrier-free aggregation-induced emission nanoparticle with efficient photosensitization and pH-responsibility. Chemical Engineering Journal, 2020,390, 124447. (亮点:构建无载体AIE纳米药物,祝贺程国辉!) Congcong Wang, Ruiguo Zhang, Jian Tan, Zhaowei Meng, Yueqian Zhang, Ning Li, Hanjie Wang, Jin Chang and Renfei Wang*. Effect of mesoporous silica nanoparticles co-loading with 17-AAG and Torin2 on anaplastic thyroid carcinoma by targeting VEGFR2.Oncology Reports,2020, 43(5), 1491-1502. Hanjie Wang, Chaonan Zhang, Yingying Zhang, Ran Tian, Guohui Cheng, Huizhuo Pan, Meihui Cui and Jin Chang*. An efficient delivery of photosensitizers and hypoxic prodrugs for a tumor combination therapy by membrane camouflage nanoparticle. Journal of Materials Chemistry B, 2020, 8(14), 2876-2886. Limin Wu, Yuye Wang*, Yingying Zhang, Hanjie Wang, Bin Liao, Sheng Gong, Tunan Chen, Nan Wu, Hua Feng and Jianquan Yao. Horizontal-scanning attenuated total reflection terahertz imaging for biological tissues. Neurophotonics, 2020, 7(2), 025005. Tao Sun, Yingying Zhang, Chaonan Zhang, Hanjie Wang, Huizhuo Pan, Jing Liu, Zhixiang Li, Lei Chen, Jin Chang* and Weiwen Zhang*. Frontiers in bioengineering and biotechnology, 2020,8(237),237. Jiameng Li, Hang Xu, Zian Zhang, Yafeng Hao, Hanjie Wang and Xian Huang. Anhydride-Assisted Spontaneous Room Temperature Sintering of Printed Bioresorbable Electronics. Advanced Functional Materials, 2020, 30(29), 1905024. Minye Yang, Meihui Cui, Weixun Wang, Dongdong Yang, Jin Chang, Jianye Hao* and Hanjie Wang*. Background-free upconversion-encoded microspheres for mycotoxin detection based on a rapid visualization method. Analytical and Bioanalytical Chemistry, 2020, 412(1), 81-91. (亮点:构建稀土上转换编码微球,用于智能手机毒素检测,祝贺杨旻晔!) Yingying Zhang, Hongbin Chen, Hanjie Wang*, Tiange Wang, Huizhuo Pan, Wanying Ji and Jin Chang*. A synergistic cancer immunotherapy nano-system for preventing tumor growth. Chemical Engineering Journal, 2020, 380, 122472. (亮点:构建协同纳米递药体系,用于术后肿瘤免疫治疗研究,祝贺张英英!)

学术兼职

中国颗粒学会(一级学会)青年委员

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