Srinivasan, Rajavel - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 2009 Ph. D. National University of Singapore, Singapore 2010-2013 Postdoctoral University of Cambridge, United Kingdom Professional Experience： 2020-09 to present | Adjunct Principal Investigator | Singapore Eye Research Institute 2015-11 to present | Associate Professor (School of Pharmaceutical Science and Technology) | Tianjin University 2013-03 to 2015-11 | Scientist I (ICES) | Agency for Science Technology and Research Honors and Awards： TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007 Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007

研究领域

The research in the group of Srinivasan encompasses two main areas, 1) Developing new reaction methodologies: The research topics under this area include bioorthogonal reactions, late-stage modification of advanced chemical entities, C-H activation, and high-throughput amenable synthesis – aiming at advancing the way organic molecules are made for drug discovery and chemical biology applications. 2) Inhibitor discovery based on fragment-based approaches: Design and synthesis of ‘unconventional’ fragments with rich structural diversity. These fragments will be used as a starting point towards novel inhibitors for unexplored biological targets such as the AurB-INCENP interaction.

近期论文

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Chemoselective N-Acylation of Amines with Acylsilanes under Aqueous Acidic Conditions Jing Tian, Wei Li, Xingwang Deng, Rajamani Lakshminarayanan, and Rajavel Srinivasan* Cite this: Org. Lett. 2023, 25, 31, 5740–5744 Publication Date:July 29, 2023 https://doi.org/10.1021/acs.orglett.3c01911 A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death Scott Duncan E.,Francis-Newton Nicola J.,Marsh May E.,Coyne Anthony G.,Fischer Gerhard,Moschetti Tommaso,Bayly Andrew R.,Sharpe Timothy D.,Haas Kalina T.,Barber Lorraine,Valenzano Chiara R.,Srinivasan Rajavel,Huggins David J.,Lee Miyoung,Emery Amy,Hardwick Bryn,Ehebauer Matthias,Dagostin Claudio,Esposito Alessandro,Pellegrini Luca,Perrior Trevor,McKenzie Grahame,Blundell Tom L.,Hyvönen Marko,Skidmore John,Venkitaraman Ashok R.,Abell Chris Page:835-847.e5 ISSN:2451-9456 2021 Container-title:Cell Chemical Biology Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions Xingwang Deng, Guan Zhou, Jing Tian, Prof. Dr. Rajavel Srinivasan First published: 01 November 2020 https://doi.org/10.1002/anie.202012459 Rapid Access to Diverse Potassium Acyltrifluoroborates (KATs) through Late-Stage Chemoselective Cross-Coupling Reactions Xingwang Deng, Guan Zhou, Xiao Han, Khadim Ullah, and Rajavel Srinivasan* Cite this: Org. Lett. 2021, 23, 5, 1886–1890 Publication Date:February 16, 2021 https://doi.org/10.1021/acs.orglett.1c00305 SLAP reagents for the photocatalytic synthesis of C3/C5-substituted, N-unprotected selenomorpholines and 1,4-selenazepanes Zhou Guan,Deng Xingwang,Pan Chenyu,Goh Eunice Tze Leng,Lakshminarayanan Rajamani,Srinivasan Rajavel Page:12546-12549 ISSN:1359-7345 2020 Container-title:Chemical Communications Synthesis and spectral properties of 6′-triazolyl-dihydroxanthene-hemicyanine fused near-infrared dyes New Journal of Chemistry 2020 | Journal article DOI: 10.1039/D0NJ01724H CONTRIBUTORS: Lingyue Gu; Kévin Renault; Anthony Romieu; Jean-Alexandre Richard; Rajavel Srinivasan SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation Zhou Guan,Deng Xingwang,Tian Jing,Fazil Mobashar Hussain Urf Turabe,Lakshminarayanan Rajamani,Srinivasan Rajavel Page:1780-1783 ISSN:1359-7345 2020 Container-title:Chemical Communications Sterically controlled C–H/C–H homocoupling of arenes via C–H borylation Pei Xiaocong,Zhou Guan,Li Xuejing,Xu Yuchen,Panicker Resmi C.,Srinivasan Rajavel Page:5703-5707 ISSN:1477-0520 2019 Container-title:Organic & Biomolecular Chemistry Divergent synthesis of 5′,7′-difluorinated dihydroxanthene-hemicyanine fused near-infrared fluorophores Organic and Biomolecular Chemistry 2019 | Journal article DOI: 10.1039/c9ob00568d EID: 2-s2.0-85065208941 CONTRIBUTORS: Zheng, S.; Lingyue, G.; Ong, M.J.H.; Jacquemin, D.; Romieu, A.; Richard, J.-A.; Srinivasan, R. Functionalization at Will of Rim-Differentiated Pillar[5]arenes Paul Demay-Drouhard, Ke Du, Kushal Samanta, Xintong Wan, Weiwei Yang, Rajavel Srinivasan, Andrew C.-H. Sue*, and Han Zuilhof* Cite this: Org. Lett. 2019, 21, 11, 3976–3980 Publication Date:April 19, 2019 https://doi.org/10.1021/acs.orglett.9b01123 Divergent synthesis of 5′,7′-difluorinated dihydroxanthene-hemicyanine fused near-infrared fluorophores Organic & Biomolecular Chemistry 2019 | Journal article DOI: 10.1039/C9OB00568D CONTRIBUTORS: Shasha Zheng; Gu Lingyue; Michelle Jui Hsien Ong; Denis Jacquemin; Anthony Romieu; Jean-Alexandre Richard; Rajavel Srinivasan meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C−H Borylation Xuejing Li, Xingwang Deng, Dr. Anthony G. Coyne, Prof. Rajavel Srinivasan First published: 11 April 2019 https://doi.org/10.1002/chem.201901633