个人简介
Education Experience:
2009 Ph. D. National University of Singapore, Singapore
2010-2013 Postdoctoral University of Cambridge, United Kingdom
Professional Experience:
2020-09 to present | Adjunct Principal Investigator | Singapore Eye Research Institute
2015-11 to present | Associate Professor (School of Pharmaceutical Science and Technology) | Tianjin University
2013-03 to 2015-11 | Scientist I (ICES) | Agency for Science Technology and Research
Honors and Awards:
TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007
Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007
研究领域
The research in the group of Srinivasan encompasses two main areas, 1) Developing new reaction methodologies: The research topics under this area include bioorthogonal reactions, late-stage modification of advanced chemical entities, C-H activation, and high-throughput amenable synthesis – aiming at advancing the way organic molecules are made for drug discovery and chemical biology applications. 2) Inhibitor discovery based on fragment-based approaches: Design and synthesis of ‘unconventional’ fragments with rich structural diversity. These fragments will be used as a starting point towards novel inhibitors for unexplored biological targets such as the AurB-INCENP interaction.
近期论文
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Chemoselective N-Acylation of Amines with Acylsilanes under Aqueous Acidic Conditions
Jing Tian, Wei Li, Xingwang Deng, Rajamani Lakshminarayanan, and Rajavel Srinivasan*
Cite this: Org. Lett. 2023, 25, 31, 5740–5744
Publication Date:July 29, 2023
https://doi.org/10.1021/acs.orglett.3c01911
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
Scott Duncan E.,Francis-Newton Nicola J.,Marsh May E.,Coyne Anthony G.,Fischer Gerhard,Moschetti Tommaso,Bayly Andrew R.,Sharpe Timothy D.,Haas Kalina T.,Barber Lorraine,Valenzano Chiara R.,Srinivasan Rajavel,Huggins David J.,Lee Miyoung,Emery Amy,Hardwick Bryn,Ehebauer Matthias,Dagostin Claudio,Esposito Alessandro,Pellegrini Luca,Perrior Trevor,McKenzie Grahame,Blundell Tom L.,Hyvönen Marko,Skidmore John,Venkitaraman Ashok R.,Abell Chris
Page:835-847.e5 ISSN:2451-9456 2021
Container-title:Cell Chemical Biology
Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions
Xingwang Deng, Guan Zhou, Jing Tian, Prof. Dr. Rajavel Srinivasan
First published: 01 November 2020 https://doi.org/10.1002/anie.202012459
Rapid Access to Diverse Potassium Acyltrifluoroborates (KATs) through Late-Stage Chemoselective Cross-Coupling Reactions
Xingwang Deng, Guan Zhou, Xiao Han, Khadim Ullah, and Rajavel Srinivasan*
Cite this: Org. Lett. 2021, 23, 5, 1886–1890
Publication Date:February 16, 2021
https://doi.org/10.1021/acs.orglett.1c00305
SLAP reagents for the photocatalytic synthesis of C3/C5-substituted, N-unprotected selenomorpholines and 1,4-selenazepanes
Zhou Guan,Deng Xingwang,Pan Chenyu,Goh Eunice Tze Leng,Lakshminarayanan Rajamani,Srinivasan Rajavel
Page:12546-12549 ISSN:1359-7345 2020
Container-title:Chemical Communications
Synthesis and spectral properties of 6′-triazolyl-dihydroxanthene-hemicyanine fused near-infrared dyes
New Journal of Chemistry
2020 | Journal article
DOI: 10.1039/D0NJ01724H
CONTRIBUTORS: Lingyue Gu; Kévin Renault; Anthony Romieu; Jean-Alexandre Richard; Rajavel Srinivasan
SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation
Zhou Guan,Deng Xingwang,Tian Jing,Fazil Mobashar Hussain Urf Turabe,Lakshminarayanan Rajamani,Srinivasan Rajavel
Page:1780-1783 ISSN:1359-7345 2020
Container-title:Chemical Communications
Sterically controlled C–H/C–H homocoupling of arenes via C–H borylation
Pei Xiaocong,Zhou Guan,Li Xuejing,Xu Yuchen,Panicker Resmi C.,Srinivasan Rajavel
Page:5703-5707 ISSN:1477-0520 2019
Container-title:Organic & Biomolecular Chemistry
Divergent synthesis of 5′,7′-difluorinated dihydroxanthene-hemicyanine fused near-infrared fluorophores
Organic and Biomolecular Chemistry
2019 | Journal article
DOI: 10.1039/c9ob00568d
EID: 2-s2.0-85065208941
CONTRIBUTORS: Zheng, S.; Lingyue, G.; Ong, M.J.H.; Jacquemin, D.; Romieu, A.; Richard, J.-A.; Srinivasan, R.
Functionalization at Will of Rim-Differentiated Pillar[5]arenes
Paul Demay-Drouhard, Ke Du, Kushal Samanta, Xintong Wan, Weiwei Yang, Rajavel Srinivasan, Andrew C.-H. Sue*, and Han Zuilhof*
Cite this: Org. Lett. 2019, 21, 11, 3976–3980
Publication Date:April 19, 2019
https://doi.org/10.1021/acs.orglett.9b01123
Divergent synthesis of 5′,7′-difluorinated dihydroxanthene-hemicyanine fused near-infrared fluorophores
Organic & Biomolecular Chemistry
2019 | Journal article
DOI: 10.1039/C9OB00568D
CONTRIBUTORS: Shasha Zheng; Gu Lingyue; Michelle Jui Hsien Ong; Denis Jacquemin; Anthony Romieu; Jean-Alexandre Richard; Rajavel Srinivasan
meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C−H Borylation
Xuejing Li, Xingwang Deng, Dr. Anthony G. Coyne, Prof. Rajavel Srinivasan
First published: 11 April 2019 https://doi.org/10.1002/chem.201901633