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个人简介

Education Experience: 2003-2007 Bachelor of Science Biological Engineering Northwest University 2008-2010 M.S. Chemical Engineering Tianjin University 2010-2013 Ph. D. Chemical Engineering Tianjin University Professional Experience: 2013- School of Life Sciences → Tianjin University → Associate professor Honors & Awards: 2020年天津大学优秀工会积极分子 2016年天津市“131”第三层次人才 2016年天津大学“北洋青年骨干教师” 2016年“天津大学生命科学学院优秀共产党员” 主持和参与科研项目: 1. 国家自然科学基金青年项目,模拟生理环境下碱性磷酸酶的折叠、稳定性及分形催化动力学研究,主持 2. 天津市自然科学基金面上项目,抗糖尿病天然产物α-淀粉酶/α-葡萄糖苷酶抑制剂的靶向筛选及作用机制研究,主持 3. 天津市自然科学基金青年项目,拥挤环境中碱性磷酸酶折叠机制与分形催化动力学研究,主持 4. 天津市出入境检验检疫局项目,橙汁、苹果汁香气成分品质分析与鉴伪方法研究,主持 5. 北洋青年骨干教师基金,抗糖尿病天然活性成分的筛选与作用机制研究,主持 6. 国家自然科学基金面上项目,颗粒物与蛋白质相互作用研究:吸附-脱附行为与淀粉样聚集,参与 7. 国家自然科学基金面上项目,多肽自组装模拟酶的构建、机理与应用,参与 8. 国家自然科学基金面上项目,多态太赫兹频谱技术及其蛋白质聚集水化层特性研究,参与 9. 国家自然科学基金面上项目,二肽超分子自组装的调控、机理与应用,参与 10.国家自然科学基金青年项目,具有肌肽合成活性的新型印迹酶分子构建及其稳定化研究,参与

研究领域

目前主要从事天然产物、酶工程等领域基础研究与应用开发工作,即研究从中草药中筛选和提取天然活性成分来治疗糖尿病。此外,在蛋白质结构与功能关系、酶促反应机理与动力学、蛋白质与药物相互作用等方向也开展相关研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Studies on the inhibition of α-glucosidase by biflavonoids and their interaction mechanisms Huan Li , Jichen Yang , Mengfan Wang , Xiangzhao Ma , Xin Peng Food Chemistry,Volume 420, 15 September 2023, 136113 https://doi.org/10.1016/j.foodchem.2023.136113 Binding of ankaflavin with bovine serum albumin (BSA) in the presence of carrageenan and protective effects of Monascus yellow pigments against oxidative damage to BSA after forming a complex with carrageenan Wu Shufen,Wang Wenyu,Lu Jingwen,Deng Weili,Zhao Nan,Sun Yue,Liu Huanhuan,Li Zhenjing,Chen Mianhua,Cheng Lei,Guo Qingbin,Wang Changlu,Peng Xin Page:2459-2471 ISSN:2042-6496 2023 Container-title:Food & Function A covalent crosslinking strategy to construct a robust peptide-based artificial esterase Soft Matter 2023 | Journal article DOI: 10.1039/D3SM00284E CONTRIBUTORS: Yi Tian; Lijun Yang; Xin Peng; Wei Qi; Mengfan Wang Effect of macromolecular crowding on the inhibition of non-enzymatic glycation of bovine serum albumin by cichoric acid Food Bioscience 2023-06 | Journal article DOI: 10.1016/j.fbio.2023.102801 CONTRIBUTORS: Yapu Zhang; Chuanying Zhang; Mengfan Wang; Kexin Du; Xin Peng Jiang, H., Liu, C., Qu, Q. et al. Development of SERS-based immunoassay for the detection of cryptococcosis biomarker. Anal Bioanal Chem 414, 4645–4654 (2022). https://doi.org/10.1007/s00216-022-04081-9 The noncovalent conjugations of human serum albumin (HSA) with MS/AK and the effect on anti-oxidant capacity as well as anti-glycation activity of Monascus yellow pigments Food & Function 2021 | Journal article DOI: 10.1039/D0FO03025B CONTRIBUTORS: Shufen Wu; Yue Sun; Di Chen; Huanhuan Liu; Zhenjing Li; Mianhua Chen; Changlu Wang; Lei Cheng; Qingbin Guo; Xin Peng Inhibition Mechanism of α-Amylase/α-Glucosidase by Silibinin, Its Synergism with Acarbose, and the Effect of Milk Proteins Journal of Agricultural and Food Chemistry 2021-09-15 | Journal article DOI: 10.1021/acs.jafc.1c01765 CONTRIBUTORS: Jichen Yang; Huan Li; Xiaoli Wang; Chuanying Zhang; Guo Feng; Xin Peng Alizarin and Purpurin from Rubia tinctorum L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity ACS Chemical Neuroscience 2021-06-16 | Journal article DOI: 10.1021/acschemneuro.1c00177 CONTRIBUTORS: Wen Wang; Jiaxing Zhang; Wei Qi; Rongxin Su; Zhimin He; Xin Peng Prediction model to analyze the performance of VMD desalination process Computers and Chemical Engineering 2020 | Journal article DOI: 10.1016/j.compchemeng.2019.106619 EID: 2-s2.0-85073942384 CONTRIBUTORS: Yang, C.; Peng, X.; Zhao, Y.; Wang, X.; Fu, J.; Liu, K.; Li, Y.; Li, P. Bio-inspired modification of superhydrophilic iPP membrane based on polydopamine and graphene oxide for highly antifouling performance and reusability Materials Letters 2019 | Journal article DOI: 10.1016/j.matlet.2019.126573 EID: 2-s2.0-85071103159 CONTRIBUTORS: Wang, X.; Peng, X.; Zhao, Y.; Yang, C.; Qi, K.; Li, Y.; Li, P. Experimental study on VMD and its performance comparison with AGMD for treating copper-containing solution Chemical Engineering Science 2019 | Journal article DOI: 10.1016/j.ces.2019.07.013 EID: 2-s2.0-85068776615 CONTRIBUTORS: Yang, C.; Peng, X.; Zhao, Y.; Wang, X.; Cheng, L.; Wang, F.; Li, Y.; Li, P. Investigation of the molecular interactions of triclocarban with human serum albumin using multispectroscopies and molecular modeling Journal of Biomolecular Structure and Dynamics 2019 | Journal article DOI: 10.1080/07391102.2018.1520149 EID: 2-s2.0-85056199516 CONTRIBUTORS: Guan, J.; Yan, X.; Zhao, Y.; Lu, J.; Sun, Y.; Peng, X. Protamine-induced condensation of peptide nanofilaments into twisted bundles with controlled helical geometry Journal of Peptide Science 2019 | Journal article DOI: 10.1002/psc.3176 EID: 2-s2.0-85068977186 CONTRIBUTORS: Wang, J.; Jia, J.; Wang, Y.; Xing, Q.; Peng, X.; Qi, W.; Su, R.; He, Z. Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation FEBS Journal 2019 | Journal article DOI: 10.1111/febs.14943 EID: 2-s2.0-85068381452 CONTRIBUTORS: Kong, J.; Wang, M.-M.; He, S.-Y.; Peng, X.; Qin, X.-H. Binding studies of triclocarban with bovine serum albumin: Insights from multi-spectroscopy and molecular modeling methods Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2018 | Journal article DOI: 10.1016/j.saa.2018.04.070 EID: 2-s2.0-85046884140 CONTRIBUTORS: Guan, J.; Yan, X.; Zhao, Y.; Sun, Y.; Peng, X.

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