个人简介
Education Experience:
2003-2007 Bachelor of Science Biological Engineering Northwest University
2008-2010 M.S. Chemical Engineering Tianjin University
2010-2013 Ph. D. Chemical Engineering Tianjin University
Professional Experience:
2013- School of Life Sciences → Tianjin University → Associate professor
Honors & Awards:
2020年天津大学优秀工会积极分子
2016年天津市“131”第三层次人才
2016年天津大学“北洋青年骨干教师”
2016年“天津大学生命科学学院优秀共产党员”
主持和参与科研项目:
1. 国家自然科学基金青年项目,模拟生理环境下碱性磷酸酶的折叠、稳定性及分形催化动力学研究,主持
2. 天津市自然科学基金面上项目,抗糖尿病天然产物α-淀粉酶/α-葡萄糖苷酶抑制剂的靶向筛选及作用机制研究,主持
3. 天津市自然科学基金青年项目,拥挤环境中碱性磷酸酶折叠机制与分形催化动力学研究,主持
4. 天津市出入境检验检疫局项目,橙汁、苹果汁香气成分品质分析与鉴伪方法研究,主持
5. 北洋青年骨干教师基金,抗糖尿病天然活性成分的筛选与作用机制研究,主持
6. 国家自然科学基金面上项目,颗粒物与蛋白质相互作用研究:吸附-脱附行为与淀粉样聚集,参与
7. 国家自然科学基金面上项目,多肽自组装模拟酶的构建、机理与应用,参与
8. 国家自然科学基金面上项目,多态太赫兹频谱技术及其蛋白质聚集水化层特性研究,参与
9. 国家自然科学基金面上项目,二肽超分子自组装的调控、机理与应用,参与
10.国家自然科学基金青年项目,具有肌肽合成活性的新型印迹酶分子构建及其稳定化研究,参与
研究领域
目前主要从事天然产物、酶工程等领域基础研究与应用开发工作,即研究从中草药中筛选和提取天然活性成分来治疗糖尿病。此外,在蛋白质结构与功能关系、酶促反应机理与动力学、蛋白质与药物相互作用等方向也开展相关研究。
近期论文
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Studies on the inhibition of α-glucosidase by biflavonoids and their interaction mechanisms
Huan Li , Jichen Yang , Mengfan Wang , Xiangzhao Ma , Xin Peng
Food Chemistry,Volume 420, 15 September 2023, 136113
https://doi.org/10.1016/j.foodchem.2023.136113
Binding of ankaflavin with bovine serum albumin (BSA) in the presence of carrageenan and protective effects of Monascus yellow pigments against oxidative damage to BSA after forming a complex with carrageenan
Wu Shufen,Wang Wenyu,Lu Jingwen,Deng Weili,Zhao Nan,Sun Yue,Liu Huanhuan,Li Zhenjing,Chen Mianhua,Cheng Lei,Guo Qingbin,Wang Changlu,Peng Xin
Page:2459-2471 ISSN:2042-6496 2023
Container-title:Food & Function
A covalent crosslinking strategy to construct a robust peptide-based artificial esterase
Soft Matter
2023 | Journal article
DOI: 10.1039/D3SM00284E
CONTRIBUTORS: Yi Tian; Lijun Yang; Xin Peng; Wei Qi; Mengfan Wang
Effect of macromolecular crowding on the inhibition of non-enzymatic glycation of bovine serum albumin by cichoric acid
Food Bioscience
2023-06 | Journal article
DOI: 10.1016/j.fbio.2023.102801
CONTRIBUTORS: Yapu Zhang; Chuanying Zhang; Mengfan Wang; Kexin Du; Xin Peng
Jiang, H., Liu, C., Qu, Q. et al. Development of SERS-based immunoassay for the detection of cryptococcosis biomarker. Anal Bioanal Chem 414, 4645–4654 (2022). https://doi.org/10.1007/s00216-022-04081-9
The noncovalent conjugations of human serum albumin (HSA) with MS/AK and the effect on anti-oxidant capacity as well as anti-glycation activity of Monascus yellow pigments
Food & Function
2021 | Journal article
DOI: 10.1039/D0FO03025B
CONTRIBUTORS: Shufen Wu; Yue Sun; Di Chen; Huanhuan Liu; Zhenjing Li; Mianhua Chen; Changlu Wang; Lei Cheng; Qingbin Guo; Xin Peng
Inhibition Mechanism of α-Amylase/α-Glucosidase by Silibinin, Its Synergism with Acarbose, and the Effect of Milk Proteins
Journal of Agricultural and Food Chemistry
2021-09-15 | Journal article
DOI: 10.1021/acs.jafc.1c01765
CONTRIBUTORS: Jichen Yang; Huan Li; Xiaoli Wang; Chuanying Zhang; Guo Feng; Xin Peng
Alizarin and Purpurin from Rubia tinctorum L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity
ACS Chemical Neuroscience
2021-06-16 | Journal article
DOI: 10.1021/acschemneuro.1c00177
CONTRIBUTORS: Wen Wang; Jiaxing Zhang; Wei Qi; Rongxin Su; Zhimin He; Xin Peng
Prediction model to analyze the performance of VMD desalination process
Computers and Chemical Engineering
2020 | Journal article
DOI: 10.1016/j.compchemeng.2019.106619
EID: 2-s2.0-85073942384
CONTRIBUTORS: Yang, C.; Peng, X.; Zhao, Y.; Wang, X.; Fu, J.; Liu, K.; Li, Y.; Li, P.
Bio-inspired modification of superhydrophilic iPP membrane based on polydopamine and graphene oxide for highly antifouling performance and reusability
Materials Letters
2019 | Journal article
DOI: 10.1016/j.matlet.2019.126573
EID: 2-s2.0-85071103159
CONTRIBUTORS: Wang, X.; Peng, X.; Zhao, Y.; Yang, C.; Qi, K.; Li, Y.; Li, P.
Experimental study on VMD and its performance comparison with AGMD for treating copper-containing solution
Chemical Engineering Science
2019 | Journal article
DOI: 10.1016/j.ces.2019.07.013
EID: 2-s2.0-85068776615
CONTRIBUTORS: Yang, C.; Peng, X.; Zhao, Y.; Wang, X.; Cheng, L.; Wang, F.; Li, Y.; Li, P.
Investigation of the molecular interactions of triclocarban with human serum albumin using multispectroscopies and molecular modeling
Journal of Biomolecular Structure and Dynamics
2019 | Journal article
DOI: 10.1080/07391102.2018.1520149
EID: 2-s2.0-85056199516
CONTRIBUTORS: Guan, J.; Yan, X.; Zhao, Y.; Lu, J.; Sun, Y.; Peng, X.
Protamine-induced condensation of peptide nanofilaments into twisted bundles with controlled helical geometry
Journal of Peptide Science
2019 | Journal article
DOI: 10.1002/psc.3176
EID: 2-s2.0-85068977186
CONTRIBUTORS: Wang, J.; Jia, J.; Wang, Y.; Xing, Q.; Peng, X.; Qi, W.; Su, R.; He, Z.
Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation
FEBS Journal
2019 | Journal article
DOI: 10.1111/febs.14943
EID: 2-s2.0-85068381452
CONTRIBUTORS: Kong, J.; Wang, M.-M.; He, S.-Y.; Peng, X.; Qin, X.-H.
Binding studies of triclocarban with bovine serum albumin: Insights from multi-spectroscopy and molecular modeling methods
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
2018 | Journal article
DOI: 10.1016/j.saa.2018.04.070
EID: 2-s2.0-85046884140
CONTRIBUTORS: Guan, J.; Yan, X.; Zhao, Y.; Sun, Y.; Peng, X.