Gao, Jinming - University of Texas-Dallas

个人简介

Professor Gao received his B.S. in Chemistry from Peking University. He carried out his graduate studies under Professor George Whitesides at Harvard University and postdoctoral training with Professor Robert Langer at MIT.

研究领域

Our main research focus is to design, develop and evaluate novel nanomaterials and nanoarchitectures for cancer molecular imaging and targeted therapeutic applications. Two design principles are emphasized throughout research: (1) understand tumor pathophysiology and identify key cancer targets to improve biological specificity, and (2) build innovative nanomedicine platforms with non-linear bioresponsive properties to achieve diagnostic and therapeutic efficacy.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Ma, X.; Huang, X.; Moore, Z.; Huang, G.; Kilgore, J.A.; Wang, Y.; Hammer, S.; Williams, N.S.; Boothman, D.A.; Gao, J. Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy. J. Controlled. Release. 2015, doi:10.1016/j.jconrel.2014.12.027 PDF Ma, X.; Wang, Y.; Zhao, T; Li, Y.; Su, L.; Wang, Z.; Huang, G.; Sumer, B.D.; Gao, J. Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions. J. Am. Chem. Soc. 2014, 136, 11085-11092 PDF Li, Y.; Wang, Y.; Huang, G.; Ma, X.; Zhou, K.; Gao, J. Chaotropic-Anion-Induced Supramolecular Self-Assembly of Ionic Polymeric Micelles. Angew. Chem. Int. Ed. 2014, 53, 8074-8078 PDF Morales, J.C.; Li, L.; Fattah, F.J.; Dong, Y.; Bey, E.A.; Patel, M.; Gao, J.; Boothman, D.A. Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases. Crit. Rev. Eukaryot. Gene Expr. 2014, 24, 15-28 PDF Ma, X.; Huang, X.; Huang, G.; Li, L.; Wang, Y.; Luo, X.; Boothman, D.A.; Gao, J. Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone. Adv. Healthc. Mater. 2014, 3, 1210-1216. PDF Sun, J.Y.; Shen, J.; Thibodeaux, J.; Huang, G.; Wang, Y.; Gao, J.; Low, P.S.; Dimitrov, D.S.; Sumer, B.D. In Vivo optical imaging of folate receptor-β in Head and Neck squamous cell carcinoma. Laryngoscope. 2014, 124, E312-319. PDF Wang, Y.; Zhou, K.; Huang, G.; Hensley, C.; Huang, X.; Ma, X.; Zhao, T.; Sumer, B.D.; DeBerardinis, R.J.; Gao, J. A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Nat. Mater. 2014, 13, 204-212. PDF Zhou, H.; Stafford, J.H.; Hallac, R.R.; Zhang, L.; Huang, G.; Mason, R.P.; Gao, J.; Thorpe, P.E.; Zhao, D. Phosphatidylserine-Targeted Molecular Imaging of Tumor Vasculature by Magnetic Resonance Imaging. J. Biomed. Nanotechnol. 2013, 10, 846-855. PDF Bey, E.A.; Reinicke, K.E.; Srougi, M.C.; Varnes, M.; Anderson, V.E.; Pink, J.J.; Li, L.S.; Patel, M.; Cao. L.; Moore, Z.; Rommel, A.; Boatman, M.; Lewis, C.; Euhus, D.M.; Bornmann, W.G.; Buchsbaum, D.J.; Spitz, D.R.; Gao, J.; Boothman, D.A. Catalase Abrogates β-Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers. Mol. Cancer Ther. 2013, 12, 2110-2120 PDF Togao, O.; Kessinger, C.W.; Huang, G.; Soesbe, T.C.; Sagiyama, K.; Dimitrov, A.I.; Sherry, D.A.; Gao, J.; Takahashi, M. Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model. PLoS ONE 2013, 8(10): e77019 PDF Regonda, S.; Tian R.; Gao, J.; Greene, S.; Ding, J.; Hu, W. Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum. Biosens. Bioelectron., 2013, 45, 245–251. PDF Huang, X.; Huang, G.; Zhang, S.; Sagiyama, K.; Togao, O.; Ma, X.; Wang, Y.; Li, Y.; Soesbe, T. C.; Sumer, B. D.; Takahashi, M.; Sherry, A. D.; Gao, J. Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes. Angew. Chem. Int. Ed., 2013, 52, 8074-8078. PDF Zhang, S.; Zhou, K.; Huang, G.; Takahashi, M.; Sherry, A. D.; Gao, J. A Novel Class of Polymeric pH-Responsive MRI CEST Agents. Chem. Comm. 2013, 49, 6418-6420. PDF Huang, G.; Chen, H.; Dong, Y.; Luo, X.; Yu, H.; Moore, Z.; Bey, E.A.; Boothman, D.A.; Gao, J. Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy. Theranostics 2013, 3, 116-126. (Article was picked for the journal cover). PDF Zheng, N.; Dai, W.; Du, W.; Zhang, H.; Lei, L.; Zhang, H.; Wang, X.; Wang, J.; Zhang, X.; Gao, J.; Zhang, Q. A novel lanreotide-encoded micelle system targets paclitaxel to the tumors with overexpression of somatostatin receptors. Mol. Pharm. 2012, 9, 1175-88.PDF Huang, X.; Dong, Y.; Bey, E.A.; Kilgore, J.A.; Bair, J.S.; Li, L.S.; Patel, M; Parkinson, E.I; Wang, Y.; Williams, N.S.; Gao, J.; Hergenrother, P.J.; Boothman, D.A. An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis. Cancer Res. 2012, 72, 3038–47.PDF Zhou, K.; Liu, H.; Zhang, S.; Huang, X.; Wang, Y.; Huang, G.; Sumer, B.D.; Gao, J. Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli. J Am Chem Soc, 2012, 134, 7803-7811. PDF Yu, H.; Zou, Y.; Wang, Y.; Huang, X.N.; Huang, G.; Sumer, B.D.; Boothman, D.A. Gao, J. Overcoming Endosomal Barrier by Amphotericin B-loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery. ACS Nano, 2011, 5, 9246-55. PDF Ding, H.; Yu, H.; Dong, Y.; Tian, R.; Huang, G.; Boothman, D.A.; Sumer, B.D.; Gao, J. Photoactivation Switch from Type II to Type I Reactions by Electron-Rich Micelles for Improved Photodynamic Therapy of Cancer Cells Under Hypoxia. J. Controlled Release. 2011, 156, 276-80. PDF Ding, H.; Sumer, B.D.; Kessinger, C.W.; Dong, Y. Huang, G., Boothman, D. A. Gao, J. Nanoscopic Micelle Delivery Improves the Photophysical Properties and Efficacy of Photodynamic Therapy of Protoporphyrin IX. J. Controlled Release. 2011, 151, 271-277.PDF