Nakamura, Fumihiko - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 1990-1993 Ph. D. Animal Science Tohoku University, Japan 1994-1995 Postdoctoral Cell Biology Stanford University Professional Experience： 1995-2000 Associate Professor Tohoku University 2001-2005 Research Fellow Brigham and Women's Hospital/Harvard Medical School 2006-2008 Instructor Brigham and Women's Hospital/Harvard Medical School 2008-2016 Assistant Professor Brigham and Women's Hospital/Harvard Medical School 2016- Professor Tianjin University Honors and Awards： Japan society for the promotion of science for Japanese junior scientists Nissan Science Foundation, Japan Kurita Water and Environment Foundation, Japan Naito Foundation, Japan The HUSEC grant for an interdisciplinary seed proposal project, Harvard University, USA

研究领域

The Nakamura group focuses on the regulation of the cellular actin cytoskeleton and in particular on the molecular mechanisms of chemical and mechanical signal transduction (mechanotransduction), a conversion of mechanical forces into cellular biochemical signals. Mechanotransduction is essential for many physiological processes in diverse organisms during development and maintenance of all tissues. Defects in mechanotransduction, often caused by mutations or deregulation of proteins that disturb cellular or extracellular mechanics, are implicated in the development of various diseases, ranging from muscular dystrophies and hypertension-induced vascular and cardiac hypertrophy to cancer progression and metastasis. Despite its importance, little is known about the underlying mechanisms of mechanotransduction. The group uses a wide range of techniques including proteomics, microscopy, molecular biology, and cell biology, and appreciate collaboration with expertises in structural biology, mechanical engineering, single molecular analysis, computer simulation, and drug design.

近期论文

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UBE2A/B is the trans-acting factor mediating mechanotransduction and contact inhibition Feng, MW (Feng, Mingwei) ; Wang, JL (Wang, Jiale) ; Li, KJ (Li, Kangjing) ; Nakamura, F (Nakamura, Fumihiko) DOI：10.1042/BCJ20230208 BIOCHEMICAL JOURNAL NAP1L1 is a novel microtubule-associated protein Peng, NN (Peng, Nannan) ; Zhang, Y (Zhang, Yang) ; Zhang, XY (Zhang, Xinyue) ; Wu, HY (Wu, Hui-Yuan) ; Nakamura, F (Nakamura, Fumihiko) DOI：10.1002/cm.21761 CYTOSKELETON Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations Mao, ZF (Mao, Zhenfeng) ; Nakamura, F (Nakamura, Fumihiko) DOI：10.3389/fcell.2023.1152109 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY Unique Itinerant Ferromagnetism in 4d-electron System Ca2RuO4 Nakamura, F (Nakamura, Fumihiko) ; Ogura, H (Ogura, Hiroki) ; Sakami, T (Sakami, Tatsuhiro) ; Suzuki, T (Suzuki, Takashi) DOI：arXiv:2303.11604 ArXiv Microtubule‐associated proteins and enzymes modifying tubulin Cytoskeleton 2023-03 | Journal article DOI: 10.1002/cm.21748 CONTRIBUTORS: Nannan Peng; Fumihiko Nakamura Identification of Filamin A Mechanobinding Partner III: SAV1 Specifically Interacts with Filamin A Mechanosensitive Domain 21 Biochemistry 2023-03-21 | Journal article DOI: 10.1021/acs.biochem.2c00665 CONTRIBUTORS: Huaguan Zhang; Zhenfeng Mao; Ziwei Yang; Fumihiko Nakamura The force-dependent filamin A–G3BP1 interaction regulates phase-separated stress granule formation Journal of Cell Science 2023-03-15 | Journal article DOI: 10.1242/jcs.260684 CONTRIBUTORS: Ziyi Feng; Zhenfeng Mao; Ziwei Yang; Xiaowei Liu; Fumihiko Nakamura Importance of the filamin A-Sav1 interaction in organ size control: evidence from transgenic mice Zhang Huaguan,Yang Ziwei,Nakamura Fumihiko Page:27-37 ISSN:0214-6282 2023 Container-title:The International Journal of Developmental Biology Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton International Journal of Molecular Sciences 2022-02-14 | Journal article DOI: 10.3390/ijms23042118 CONTRIBUTORS: Jing Gao; Fumihiko Nakamura Mechanotransduction, nanotechnology, and nanomedicine Liu Xiaowei,Nakamura Fumihiko Page:284 ISSN:1674-8301 2021 Container-title:The Journal of Biomedical Research Structure and Function of Filamin C in the Muscle Z-Disc International Journal of Molecular Sciences 2020-04-13 | Journal article DOI: 10.3390/ijms21082696 CONTRIBUTORS: Zhenfeng Mao; Fumihiko Nakamura Role of mechanical flow for actin network organization Acta biomaterialia 2019 | Journal article Identification of Filamin A Mechanobinding Partner I: Smoothelin Specifically Interacts with the Filamin A Mechanosensitive Domain 21 Biochemistry 2019-11-26 | Journal article DOI: 10.1021/acs.biochem.9b00100 CONTRIBUTORS: Lina Wang; Fumihiko Nakamura Identification of Filamin A Mechanobinding Partner II: Fimbacin Is a Novel Actin Cross-Linking and Filamin A Binding Protein Biochemistry 2019-11-26 | Journal article DOI: 10.1021/acs.biochem.9b00101 CONTRIBUTORS: Jiale Wang; Fumihiko Nakamura