Lin, Zhi - 天津大学 - 药物科学与技术学院

个人简介

Education Experience 1994-1998 Bachelor of Science Biotechnology Xiamen University 1998-2001 M.S. Biochemistry & Molecular Biolology Xiamen University 2002-2006 Ph. D. Structural Biology National University of Singapore 2007-2009 Postdoctoral Structural Biology National University of Singapore Professional Experience 2006-2007 Research Assistant National University of Singapore 2009-2012 Research Fellow National University of Singapore 2012-2015 Senior Research Fellow National University of Singapore 2015-2016 Principle Investigator Tianjin University 2011-2016 Visiting Professor Ningxia Medical School 2015-2016 Visiting Senior Research Fellow National University of Singapore

研究领域

1. Bioengineering of spider fibroins Spider silks are proteinaceous biopolymers with extraordinary physical properties and biomimetic potential. This research focuses on the structure-based engineering and design of silk fibroins for the production of artificial spider silks with desirable mechanical properties. 2. NMR structural & functional studies on p75NTR signaling p75 neurotrophin receptor (p75NTR) is a member of the Tumor Necreosis Factor Superfamily and its signaling actively contributes to neurodegeneration. The aim of this project is to elucidate structural mechanisms of p75NTR signaling in the nervous system and to discover drugs for neurodegenerative diseases and nerve injury.

近期论文

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Lin, Z., Xu, Y., Yang, S., and Yang, D. (2006). Sequence-specific assignment of aromatic resonances of uniformly 13C,15N-labeled proteins by using 13C- and 15N-edited NOESY spectra. Angew. Chem. Int. Ed. 45:1960-1963. Lin, Z., Sriskanthadevan, S., Huang, H., Siu, C.H., and Yang, D. (2006). Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion. Nat Struct Mol Biol 13:1016-1022. Lin, Z., Huang, W., Zhang, J., Fan, J.S., and Yang, D. (2009). Solution structure of eggcase silk protein and its implications for silk fiber formation. Proc Natl Acad Sci USA 106:8906-8911. Lin, Z., Deng, Q., Liu, X.Y., and Yang, D. (2013). Engineered large spider eggcase silk protein for strong artificial fibers. Adv Mater 25:1216-1220. Lin, Z., Tann, J.Y., Goh, E.T., Kelly, C., Lim, K.B., Gao, J.F., and Ibanez, C.F. (2015). Structural basis of death domain signaling in the p75 neurotrophin receptor. eLife 4:e11692