NasirJalal - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 2015-2017 Postdoctoral Molecular Pharmacology Tianjin University, China 2007-2012 Ph. D. Cell and Molecular Biology Colorado State University, USA 1994-1996 Master of Science Botany University of the Punjab, Pakistan 1992-1994 Bachelor of Science Pre-medical University of the Punjab, Pakistan Professional Experience： 2022-10-01 to 2023-04-03 | Associate Professor (Regenerative medicine) | Oujiang Lab: Wenzhou 2022-01-06 to 2023-02-28 | Associate Professor (Biomedical Sciences) | Pak-Austria Fachhochschule Institute of Applied Sciences and Technology 2021-01-01 to 2023-01-01 | Adjunct Professor (Interdisciplinary Science) | Nanjing University of Information Science and Technology 2015-2017 Charles Tenney Post-doctoral fellow Tianjin University, China 2012-2014 Assistant Professor National University of Sciences and Technology, Pakistan 2010-2012 Student scientist Colorado State University, USA 2003-2007 Assistant Professor Forman Christian University, Pakistan

研究领域

构建 E-18 细胞系（修饰的 WTK1 细胞系）以更高分辨率测量旁观者诱变。将独特的18个碱基序列拼接到杂合宿主TK1基因中;在 I-Sce1 限制性内切酶的外源性表达时，在 18 个碱基序列处切割，并使杂合细胞系成为 TK1 基因的纯合隐性细胞系。这种隐性突变体可以使用突变测定法进行筛选。泊松分布分析允许在 96 孔测定中测量突变体，以确定突变频率。下图：彗星测定法用于使用荧光显微镜对 E-1 细胞中 I-Sce18 诱导的 DNA 损伤进行半定量分析。其他研究兴趣：在转化乳腺癌研究领域进行合作，专注于识别环境风险、构思新的治疗策略、测试新型抗癌药物，并为开发用于体外受精技术和定制基因治疗的生物医学设备的新原型提供见解。此外，对筛选具有治疗癌症靶蛋白潜力的新型合成先导化合物（如 Akt 1、2、3）感兴趣。

近期论文

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An Integrated Computational Analysis of High-Risk SNPs in Angiopoietin-like Proteins (ANGPTL3 and ANGPTL8) Reveals Perturbed Protein Dynamics Associated with Cancer Molecules 2023-06 | Journal article | Author DOI: 10.3390/molecules28124648 CONTRIBUTORS: Sajid Iqbal; Farida Begum; DOROTHY NYAMAI; Nasir Jalal; Peter Shaw COVID-19: The Ethno-Geographic Perspective of Differential Immunity Usman Abdullah ,Ned Saleh ,Peter Shaw and Nasir Jalal Vaccines 2023, 11(2), 319; https://doi.org/10.3390/vaccines11020319 Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 Asim Z. Abbasi, Dania A. Kiyani, Syeda M. Hamid, Muhammad Saalim PhD candidate, Ammad Fahim PhD, Nasir Jalal PhD First published: 27 February 2021 https://doi.org/10.1002/jmv.26911 Carbon-dot wrapped ZnO nanoparticle-based photoelectrochemical sensor for selective monitoring of H2O2 released from cancer cells Khan Faria,Akhtar Naeem,Jalal Nasir,Hussain Irshad,Szmigielski Rafal,Hayat Muhammad Qasim,Ahmad Hafiz B.,El-Said Waleed A.,Yang Minghui,Janjua Hussnain Ahmed ISSN:0026-3672 2019 Container-title:Microchimica Acta Low-dose bisphenol A (BPA)-induced DNA damage and tumorigenic events in MCF-10A cells Nasir Jalal,Jing Wei,Yaxin Jiang,Janak L. Pathak,Austin R. Surendranath &Chang Y. Chung |Amr Elshaer (Reviewing editor) Article: 1616356 | Received 30 Aug 2018, Accepted 08 Apr 2019, Published online: 17 May 2019 Cite this article https://doi.org/10.1080/2331205X.2019.1616356 Bisphenol A (BPA) the mighty and the mutagenic Nasir Jalal , Austin R. Surendranath , Janak L. Pathak , Shi Yu , Chang Y. Chung Toxicology Reports，Volume 5, 2018, Pages 76-84 https://doi.org/10.1016/j.toxrep.2017.12.013