ChangChung - 天津大学 - 药物科学与技术学院

个人简介

Education Experience 1990-1995 Ph. D. Duke University, NC, USA 1995-1997 Postdoctoral University of California, San Diego, USA Professional Experience 1996-1998 Teaching Assistant Seoul National University, Seoul, Korea 1991-1994 Research Assistant Duke University, Durham, NC USA 1995-1997 Postdoctoral Fellow UC-San Diego, San Diego, CA USA 1997-2001 Assistant Project Scientist UCSD 2001-2009 Assistant Professor Vanderbilt University Medical Center 2005-2014 Faculty Fellow Biosystems Research and Education 2009-2014 Associate Professor with tenure Vanderbilt University Medical Center 2015- Professor Tianjin University

研究领域

The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis. Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation. Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target. Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

近期论文

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2018 Bisphenol A (BPA) the mighty and the mutagenic. Jalal, Nasir; Surendranath, Austin R; Pathak, Janak L; et al. Toxicology reports 5 2017 ADP-ribosylation of vimentin induces changes in morphology and motility of microglia through enhancing phosphorylation of vimentin at Ser(56) and disassembly of vimentin filaments. Xie, L.; Yang, F.; Chung, C. Y. Molecular Biology of the Cell 28 2017 Role of Calcium-Independent Phospholipase A2 VIA in Mediating Neurological Disorder and Cancer Chung, Chang Y.; Shi, Yu; Surendranath, Austin R.; et al. Transactions of Tianjin University 23 2017 Signaling Pathways Controlling Microglia Chemotaxis Yang, Fan; Lirui, Xie; and Chang, Y. Chung Mol. Cells 40 2016 Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin Lee, Sang-Hyun; Sud, Neetu; Lee, Narae; et al. Journal of Biological Chemistry 291 2016 Regulation of iPLA2 Activity and Localization by Rab5. Shi, Y.; Chung, D.; Chung, C. Y. Molecular Biology of the Cell 27 2015 Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC. Wang, C; Jung, D; Cao, Z; et al. Biochemical and biophysical research communications 465 2014 Pro32Pro33 Mutations in the Integrin beta(3) PSI Domain Result in alpha IIb beta(3) Priming and Enhanced Adhesion: Reversal of the Hypercoagulability Phenotype by the Src Inhibitor SKI-606 Oliver, Kendra H.; Jessen, Tammy; Crawford, Emily L.; et al. Molecular Pharmacology 85 2013 An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis Chung, Chang Y.; Feoktistov, Alexander; Hollingsworth, Ryan J.; et al. Biochemical and Biophysical Research Communications 436 2013 Basophile: Accurate Fragment Charge State Prediction Improves Peptide Identification Rates Wang, Dong; Dasari, Surendra; Chambers, Matthew C.; et al. Genomics Proteomics & Bioinformatics 11 2013 RacC is required for the vesicular trafficking of ACA and streaming of Dictyostelium cells. Wang, C.; Cao, Z.; Jung, D.; et al. Molecular Biology of the Cell 24 2012 beta-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis Lee, Sang-Hyun; Hollingsworth, Ryan; Kwon, Hyeok-Yil; et al. Glia 60 2012 Role of iPLA2 in the regulation of the endosomal recycling of integrin and chemotactic motility of microglia Lee, S-H.; Sud, N.; Lee, N.; et al. Molecular Biology of the Cell 23 2011 Alteration of alpha 6 integrin expression and chemotactic motility of microglia upon ADP stimulation. Lee, S-H.; Chung, C. Y. Molecular Biology of the Cell 22 2011 Role of iPLA(2) in the Regulation of Src Trafficking and Microglia Chemotaxis Lee, Sang-Hyun; Schneider, Claus; Higdon, Ashlee N.; et al. Traffic 12 2010 Bimodal Analysis Reveals a General Scaling Law Governing Nondirected and Chemotactic Cell Motility Gruver, J. Scott; Potdar, Alka A.; Jeon, Junhwan; et al. Biophysical Journal 99 2010 Functional Roles of VASP Phosphorylation in the Regulation of Chemotaxis and Osmotic Stress Response Lin, Wan-Hsin; Nelson, Sharon E.; Hollingsworth, Ryan J.; et al. Cytoskeleton 67 2009 Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis Lee, S.; Han, J. W.; Leeper, L.; et al. Biochimica Et Biophysica Acta-Molecular Cell Research 1793 2009 Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation Lee, S.; Chung, C. Y. Molecular and Cellular Neuroscience 42 2008 3 ’-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis Gruver, J. S.; Wikswo, J. P.; Chung, C. Y. Biophysical Journal 95