研究领域
The pathologic mechanism underlying hereditary rare diseases, e.g., intellectual disability syndrome, progressive symmetric erythrokeratoderma disorders, etc.
The dynamic regulation mechanism underlying the pahogenesis particularly the replication event of significant or model viruses including SARS-CoV-2, MERS-CoV, EV71, etc.
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The tetrameric assembly of 2-aminomuconic 6-semialdehyde dehydrogenase is a functional requirement of cofactor NAD+ binding
Qiuli Shi, Yanjuan Chen, Xinxin Li, Hui Dong, Cheng Chen, Zhihui Zhong, Cheng Yang, Guangfeng Liu, Dan Su
First published: 22 November 2021 https://doi.org/10.1111/1462-2920.15840
Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2
Peiyuan Liu , Yanfeng Zhang , Zibin Li , Jianwen Huang , Tao Wang , Cheng Chen
Biochemical and Biophysical Research Communications https://doi.org/10.1016/j.bbrc.2022.03.077
Volume 606, 28 May 2022, Pages 17-22
High-throughput FastCloning technology: A low-cost method for parallel cloning
PLOS ONE
2022-09-09 | Journal article
DOI: 10.1371/journal.pone.0273873
CONTRIBUTORS: Hua Jiang; Paulo Lee Ho; Fan Meng; Deren Lu; Yanjuan Chen; Guilin Luo; Yuejun Chen; Jun Chen; Cheng Chen; Xi Zhang et al.
The tetrameric assembly of 2‐aminomuconic 6‐semialdehyde dehydrogenase is a functional requirement of cofactor NAD+ binding
Environmental Microbiology
2022-07 | Journal article
DOI: 10.1111/1462-2920.15840
CONTRIBUTORS: Qiuli Shi; Yanjuan Chen; Xinxin Li; Hui Dong; Cheng Chen; Zhihui Zhong; Cheng Yang; Guangfeng Liu; Dan Su
The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals
Viruses
2022-02-27 | Journal article
DOI: 10.3390/v14030486
CONTRIBUTORS: Fenghua Wang; Cheng Chen; Zefang Wang; Xu Han; Peidian Shi; Kaixuan Zhou; Xiaomei Liu; Yunjie Xiao; Yan Cai; Jinhai Huang et al.
Wang, H., Xiao, Y., Chen, X. et al. Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Nat Commun 13, 1608 (2022). https://doi.org/10.1038/s41467-022-29273-w
Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis
Mengmeng Lin, Wen Cui, Hongliang Tian, Yan Zhang, Chen Chen, Xiaoyun Yang, Heng Chi, Zhongyu Mu, Cheng Chen, Zefang Wang, Xiaoyun Ji*, Haitao Yang*, and Zhi Lin*
Cite this: ACS Infect. Dis. 2022, 8, 1, 150–158
Publication Date:December 14, 2021
https://doi.org/10.1021/acsinfecdis.1c00455
The tetrameric assembly of 2-aminomuconic acid dehydrogenase is a functional requirement of cofactor NAD+ binding
2021-07-16 | Other
DOI: 10.1101/2021.07.15.452591
CONTRIBUTORS: Qiuli Shi; Yanjuan Chen; Xinxin Li; Hui Dong; Cheng Chen; Zhihui Zhong; Cheng Yang; Guangfeng Liu; Dan Su
Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors
Proceedings of the National Academy of Sciences
2021-10-12 | Journal article
DOI: 10.1073/pnas.2107699118
CONTRIBUTORS: Yunjie Xiao; Hongli Chen; Haofeng Wang; Mengwen Zhang; Xia Chen; Jason M. Berk; Lilin Zhang; Yi Wei; Wenling Li; Wen Cui et al.
Corrigendum to “Crystal structure of the NS3 helicase of tick-borne encephalitis virus” [Biochem. Biophys. Res. Commun. 528(3) (2020) 601–606]
Chen Chen,Han Xu,Chen Cheng,Wang Fenghua,Huang Jinhai,Zhang Lei,Wang Zefang,Yang Haitao
Page:103 ISSN:0006-291X 2021
Container-title:Biochemical and Biophysical Research Communications
Crystal structure of the NS3 helicase of tick-borne encephalitis virus
Chen Chen,Han Xu,Chen Cheng,Wang Fenghua,Huang Jinhai,Zhang Lei,Wang Zefang,Yang Haitao
Page:601-606 ISSN:0006-291X 2020
Container-title:Biochemical and Biophysical Research Communications
Dan Fu#, Dongming Zhao#, Wei Zhang#, Guangshun Zhang, Mingyu Li, Zheng Zhang, Yuhui Wang, Dongdong Sun, Peng Jiao, Cheng Chen*, Yu Guo*, and Zihe Rao, Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding, Protein Cell, 2020, 11(8): 606-612. (IF: 10.164)
Wen Cui#, Shanshan Cui#, Cheng Chen#, Xia Chen, Zefang Wang*, Haitao Yang, and Lei Zhang*, The crystal structure of main protease from mouse hepatitis virus A59 in complex with an inhibitor, Biochem Biophys Res Commun, 2019, 511(4): 794-799. (IF: 2.705)
Xiaoyun Yang#, Cheng Chen#, Hongliang Tian#, Heng Chi, Zhongyu Mu, Tianqing Zhang, Kailin Yang, Qi Zhao, Xiaohua Liu, Zefang Wang*, Xiaoyun Ji, Haitao Yang*, Mechanism of ATP hydrolysis by the Zika virus helicase, FASEB Journal, 2018: fj201701140R. (IF: 5.391)
Li Wang#, Bo-Bo Bao#, Guo-Qing Song, Cheng Chen*, Xu-Meng Zhang, Wei Lu, Zefang Wang, Yan Cai, Shuang Li, Sheng Fu, Fu-Hang Song, Haitao Yang, and Jian-Guo Wang*, Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study, European Journal of Medicinal Chemistry, 2017. 137: 450-461. (IF: 4.816)
Tingting Hu#, Cheng Chen#, Huiyan Li, Yanshu Dou, Ming Zhou, Deren Lu, Qi Zong, Yulei Li, Cheng Yang, Zhihui Zhong, Namit Singh, Honggang Hu, Rundong Zhang, Haitao Yang*, and Dan Su*, Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9, Protein Science, 2017. 26(5): 1037-1048. (IF: 2.41)
Fenghua Wang#, Cheng Chen#, Kailin Yang#, Yang Xu, Xiaowei Liu, Fan Gao, He Liu, Xia Chen, Qi Zhao, Xiang Liu, Yan Cai*, and Haitao Yang*, Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus, Journal of Medicinal Chemistry, 2017. 60(7): 3212-3216. (IF: 6.253)
Deping Wang#, Cheng Chen#, Shengnan Liu#, Han Zhou#, Kailin Yang, Qi Zhao, Xiaoyun Ji, Chen CHEN, Wei Xie, Zefang Wang, Li-Zhi Mi*, and Haitao Yang*, A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro, Scientific Reports, 2017. 7: 42580. (IF: 4.122)
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