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个人简介

教育经历: 2006.9 - 2013.7 Tsinghua University - Biology - 博士 2002.9 - 2006.6 Nanjin University - Biophysics - 学士 工作经历: 2018.8- 至今 School of Life Sciences → Tianjin University → Associate professor 2016.2 - 2016.7 Division of Structural Biology, Nuffield Department of Clinical Medicine → Oxford University → Visiting Scholar 2013.7 - 2018.7 School of Life Sciences → Tianjin University → Lecturer 授课信息: Fundamentals of Biostatistics Cognition Fieldwork Pathogens, Host and Structure

研究领域

The pathologic mechanism underlying hereditary rare diseases, e.g., intellectual disability syndrome, progressive symmetric erythrokeratoderma disorders, etc. The dynamic regulation mechanism underlying the pahogenesis particularly the replication event of significant or model viruses including SARS-CoV-2, MERS-CoV, EV71, etc.

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

The tetrameric assembly of 2-aminomuconic 6-semialdehyde dehydrogenase is a functional requirement of cofactor NAD+ binding Qiuli Shi, Yanjuan Chen, Xinxin Li, Hui Dong, Cheng Chen, Zhihui Zhong, Cheng Yang, Guangfeng Liu, Dan Su First published: 22 November 2021 https://doi.org/10.1111/1462-2920.15840 Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2 Peiyuan Liu , Yanfeng Zhang , Zibin Li , Jianwen Huang , Tao Wang , Cheng Chen Biochemical and Biophysical Research Communications https://doi.org/10.1016/j.bbrc.2022.03.077 Volume 606, 28 May 2022, Pages 17-22 High-throughput FastCloning technology: A low-cost method for parallel cloning PLOS ONE 2022-09-09 | Journal article DOI: 10.1371/journal.pone.0273873 CONTRIBUTORS: Hua Jiang; Paulo Lee Ho; Fan Meng; Deren Lu; Yanjuan Chen; Guilin Luo; Yuejun Chen; Jun Chen; Cheng Chen; Xi Zhang et al. The tetrameric assembly of 2‐aminomuconic 6‐semialdehyde dehydrogenase is a functional requirement of cofactor NAD+ binding Environmental Microbiology 2022-07 | Journal article DOI: 10.1111/1462-2920.15840 CONTRIBUTORS: Qiuli Shi; Yanjuan Chen; Xinxin Li; Hui Dong; Cheng Chen; Zhihui Zhong; Cheng Yang; Guangfeng Liu; Dan Su The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals Viruses 2022-02-27 | Journal article DOI: 10.3390/v14030486 CONTRIBUTORS: Fenghua Wang; Cheng Chen; Zefang Wang; Xu Han; Peidian Shi; Kaixuan Zhou; Xiaomei Liu; Yunjie Xiao; Yan Cai; Jinhai Huang et al. Wang, H., Xiao, Y., Chen, X. et al. Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Nat Commun 13, 1608 (2022). https://doi.org/10.1038/s41467-022-29273-w Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis Mengmeng Lin, Wen Cui, Hongliang Tian, Yan Zhang, Chen Chen, Xiaoyun Yang, Heng Chi, Zhongyu Mu, Cheng Chen, Zefang Wang, Xiaoyun Ji*, Haitao Yang*, and Zhi Lin* Cite this: ACS Infect. Dis. 2022, 8, 1, 150–158 Publication Date:December 14, 2021 https://doi.org/10.1021/acsinfecdis.1c00455 The tetrameric assembly of 2-aminomuconic acid dehydrogenase is a functional requirement of cofactor NAD+ binding 2021-07-16 | Other DOI: 10.1101/2021.07.15.452591 CONTRIBUTORS: Qiuli Shi; Yanjuan Chen; Xinxin Li; Hui Dong; Cheng Chen; Zhihui Zhong; Cheng Yang; Guangfeng Liu; Dan Su Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors Proceedings of the National Academy of Sciences 2021-10-12 | Journal article DOI: 10.1073/pnas.2107699118 CONTRIBUTORS: Yunjie Xiao; Hongli Chen; Haofeng Wang; Mengwen Zhang; Xia Chen; Jason M. Berk; Lilin Zhang; Yi Wei; Wenling Li; Wen Cui et al. Corrigendum to “Crystal structure of the NS3 helicase of tick-borne encephalitis virus” [Biochem. Biophys. Res. Commun. 528(3) (2020) 601–606] Chen Chen,Han Xu,Chen Cheng,Wang Fenghua,Huang Jinhai,Zhang Lei,Wang Zefang,Yang Haitao Page:103 ISSN:0006-291X 2021 Container-title:Biochemical and Biophysical Research Communications Crystal structure of the NS3 helicase of tick-borne encephalitis virus Chen Chen,Han Xu,Chen Cheng,Wang Fenghua,Huang Jinhai,Zhang Lei,Wang Zefang,Yang Haitao Page:601-606 ISSN:0006-291X 2020 Container-title:Biochemical and Biophysical Research Communications Dan Fu#, Dongming Zhao#, Wei Zhang#, Guangshun Zhang, Mingyu Li, Zheng Zhang, Yuhui Wang, Dongdong Sun, Peng Jiao, Cheng Chen*, Yu Guo*, and Zihe Rao, Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding, Protein Cell, 2020, 11(8): 606-612. (IF: 10.164) Wen Cui#, Shanshan Cui#, Cheng Chen#, Xia Chen, Zefang Wang*, Haitao Yang, and Lei Zhang*, The crystal structure of main protease from mouse hepatitis virus A59 in complex with an inhibitor, Biochem Biophys Res Commun, 2019, 511(4): 794-799. (IF: 2.705) Xiaoyun Yang#, Cheng Chen#, Hongliang Tian#, Heng Chi, Zhongyu Mu, Tianqing Zhang, Kailin Yang, Qi Zhao, Xiaohua Liu, Zefang Wang*, Xiaoyun Ji, Haitao Yang*, Mechanism of ATP hydrolysis by the Zika virus helicase, FASEB Journal, 2018: fj201701140R. (IF: 5.391) Li Wang#, Bo-Bo Bao#, Guo-Qing Song, Cheng Chen*, Xu-Meng Zhang, Wei Lu, Zefang Wang, Yan Cai, Shuang Li, Sheng Fu, Fu-Hang Song, Haitao Yang, and Jian-Guo Wang*, Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study, European Journal of Medicinal Chemistry, 2017. 137: 450-461. (IF: 4.816) Tingting Hu#, Cheng Chen#, Huiyan Li, Yanshu Dou, Ming Zhou, Deren Lu, Qi Zong, Yulei Li, Cheng Yang, Zhihui Zhong, Namit Singh, Honggang Hu, Rundong Zhang, Haitao Yang*, and Dan Su*, Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9, Protein Science, 2017. 26(5): 1037-1048. (IF: 2.41) Fenghua Wang#, Cheng Chen#, Kailin Yang#, Yang Xu, Xiaowei Liu, Fan Gao, He Liu, Xia Chen, Qi Zhao, Xiang Liu, Yan Cai*, and Haitao Yang*, Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus, Journal of Medicinal Chemistry, 2017. 60(7): 3212-3216. (IF: 6.253) Deping Wang#, Cheng Chen#, Shengnan Liu#, Han Zhou#, Kailin Yang, Qi Zhao, Xiaoyun Ji, Chen CHEN, Wei Xie, Zefang Wang, Li-Zhi Mi*, and Haitao Yang*, A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro, Scientific Reports, 2017. 7: 42580. (IF: 4.122)

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