个人简介
Education Experience：
1994-1997 Ph. D. Medical Biochemistry UdS Medical School, Homburg, Germany
1997-2000 Postdoctoral Biochemistry Saarland University, Germany
1987-1994 Master of Science Chemistry Saarland University, Germany
Professional Experience：
2001-2004 Senior Scientist (C1) Department of Biochemistry, Saarland University, Germany
2004-2008 Senior Scientist (C2) Department of Biochemistry, Saarland University, Germany
2008-2012 CEO PomBioTech GmbH, Germany
2012-2014 Lecturer & Senior Scientist Department of Biochemistry, Saarland University, Germany
2014-07-01 to present Prof. of Biochemistry (Health Science Platform / School of Pharmaceutical Science and Technology (SPST))
Honors and Awards：
2005 – German business magazine impulse: PomBioTech was named as one of the 25 most promising start-up companies in Germany. The award address was given by Wolfgang Clement, then German Federal Minister of Economics and Labour.
2011 – PomBioTech was selected as a finalist for Red Herring's Top 100 Europe award.
研究领域
The research in the Bureik group encompasses two primary areas:
1) The study of human drug metabolizing enzymes and their use for organic synthesis. A major goal in this project involves systematic testing of all variants of drug metabolizing cytochrome P450 enzymes (CYPs or P450s) and UDP glycosyltransferases (UGTs) identified in Chinese patients. This is expected to aid doctors in choosing the correct dosage for patients.
2) Investigation of human CYP4Z1 and exploitation of its activity for the treatment of breast cancer. In this project, we have successfully identified CYP4Z1 to catalyze fatty acid in-chain hydroxylase and also ether cleavage. A primary aim is to search for compounds that can act as CYP4Z1-activated prodrugs and have potential for treatment of breast cancer.
近期论文
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Glucuronidation Pathways of 5- and 7-Hydroxypropranolol: Determination of Glucuronide Structures and Enzyme Selectivity
Molecules
2023-11-26 | Journal article
DOI: 10.3390/molecules28237783
CONTRIBUTORS: Fan Yang; Maxi Wenzel; Matthias Bureik; Maria Kristina Parr
Expected and Unexpected Products from the Biochemical Oxidation of Bacterial Alkylquinolones with CYP4F11
Journal of Natural Products
2023-11-24 | Journal article
DOI: 10.1021/acs.jnatprod.3c00689
CONTRIBUTORS: Yue Shi; Jianye Li; Clemens Alexander Wolf; Sijie Liu; Sangeeta S. Sharma; Gerhard Wolber; Matthias Bureik; Benjamin R. Clark
Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
Current Issues in Molecular Biology
2023-08-26 | Journal article
DOI: 10.3390/cimb45090451
CONTRIBUTORS: Fan Yang; Sangeeta Shrestha Sharma; Matthias Bureik; Maria Kristina Parr
Biosynthesis of Salbutamol-4′-O-sulfate as Reference for Identification of Intake Routes and Enantiopure Salbutamol Administration by Achiral UHPLC-MS/MS
Separations
2023-07-28 | Journal article
DOI: 10.3390/separations10080427
CONTRIBUTORS: Annika Lisa Jendretzki; Lukas Corbinian Harps; Yanan Sun; Felix Bredendiek; Matthias Bureik; Ulrich Girreser; Xavier de la Torre; Francesco M. Botrè; Maria Kristina Parr
Urinary Excretion Kinetics of Salbutamol and Its Sulfoconjugated Main Metabolite After Oral and Inhalative Administration of Racemic Salbutamol or Levosalbutamol
2023-02-27 | Preprint
DOI: 10.20944/preprints202302.0447.v1
CONTRIBUTORS: Annika Lisa Jendretzki; Lukas Corbinian Harps; Yanan Sun; Felix Bredendiek; Matthias Bureik; Ulrich Girreser; Xavier De la Torre; Francesco Botrè; Maria Kristina Parr
Mutual Influence of Human Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases on Their Respective Activities in Recombinant Fission Yeast
Biomedicines
2023-01-19 | Journal article
DOI: 10.3390/biomedicines11020281
CONTRIBUTORS: Sangeeta Shrestha Sharma; Shishir Sharma; Jie Zhao; Matthias Bureik
Experimental and Computational Studies on the Biotransformation of Pseudopyronines with Human Cytochrome P450 CYP4F2
Journal of Natural Products
2022-11-25 | Journal article
DOI: 10.1021/acs.jnatprod.2c00616
CONTRIBUTORS: Ya Lu; Xueling Liu; Rowaa Lotfy; Sijie Liu; Abel Fekadu Tesfa; Gerhard Wolber; Matthias Bureik; Benjamin R. Clark
Changes in Alprazolam Metabolism by CYP3A43 Mutants
Biomedicines
2022-11-23 | Journal article
DOI: 10.3390/biomedicines10123022
CONTRIBUTORS: Jie Zhao; Sijie Liu; Clemens Alexander Wolf; Gerhard Wolber; Maria Kristina Parr; Matthias Bureik
Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families
International Journal of Molecular Sciences
2022-07-05 | Journal article
DOI: 10.3390/ijms23137476
CONTRIBUTORS: Fan Yang; Sijie Liu; Gerhard Wolber; Matthias Bureik; Maria Kristina Parr
Metabolism of the antipsychotic drug olanzapine by CYP3A43
Xenobiotica
2022-04-03 | Journal article
DOI: 10.1080/00498254.2022.2078751
CONTRIBUTORS: Jie Zhao; David Machalz; Sijie Liu; Clemens Alexander Wolf; Gerhard Wolber; Maria Kristina Parr; Matthias Bureik
Upregulation of estrogen receptor alpha (ERα) expression in transgenic mice expressing human CYP4Z1
Breast Cancer Research and Treatment
2022-01 | Journal article
DOI: 10.1007/s10549-021-06435-w
CONTRIBUTORS: Christopher Khayeka-Wandabwa; Jie Zhao; Janak L. Pathak; Huiyuan Wu; Matthias Bureik
Controlled administration of dehydrochloromethyltestosterone in humans: Urinary excretion and long-term detection of metabolites for anti-doping purpose
The Journal of Steroid Biochemistry and Molecular Biology
2021-11 | Journal article
DOI: 10.1016/j.jsbmb.2021.105978
CONTRIBUTORS: Steffen Loke; Xavier de la Torre; Michele Iannone; Giuseppe La Piana; Nils Schlörer; Francesco Botrè; Matthias Bureik; Maria Kristina Parr
Structural insights into understudied human cytochrome P450 enzymes
Drug Discovery Today
2021-10 | Journal article
DOI: 10.1016/j.drudis.2021.06.006
CONTRIBUTORS: David Machalz; Szymon Pach; Marcel Bermudez; Matthias Bureik; Gerhard Wolber
Conversion of five proluciferin esters by human cytochrome P450 enzymes
Biotechnology Journal
2021-07 | Journal article
DOI: 10.1002/biot.202100007
CONTRIBUTORS: Shishir Sharma; Sangeeta Shrestha Sharma; Xue Zhang; Jan‐Philipp Bureik; Erik J. Sorensen; Matthias Bureik
Futile cycling by human microsomal cytochrome P450 enzymes within intact fission yeast cells
Archives of Biochemistry and Biophysics
2021-04 | Journal article
DOI: 10.1016/j.abb.2021.108791
CONTRIBUTORS: Dawit M. Weldemichael; Kun Zhou; Shi-jia Su; Lin Zhao; Mario Andrea Marchisio; Matthias Bureik
New Insights into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel A-Ring Reduced Metabolites
Molecules
2021-03-03 | Journal article
DOI: 10.3390/molecules26051354
CONTRIBUTORS: Steffen Loke; Lingyu Liu; Maxi Wenzel; Heike Scheffler; Michele Iannone; Xavier de la Torre; Nils Schlörer; Francesco Botrè; Annekathrin Martina Keiler; Matthias Bureik et al.
New Insights Into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel a-Ring Reduced Metabolites
2021-02-18 | Other
DOI: 10.20944/preprints202102.0420.v1
CONTRIBUTORS: Steffen Loke; Lingyu Liu; Maxi Wenzel; Heike Scheffler; Michele Iannone; Xavier de la Torre; Nils Schloerer; Francesco Botrè; Annekathrin Martina Keiler; Matthias Bureik et al.
New Proluciferin Substrates for Human CYP4 Family Enzymes
Applied Biochemistry and Biotechnology
2021-01-01 | Journal article
DOI: 10.1007/s12010-020-03388-6
CONTRIBUTORS: Jingyao Liu; David Machalz; Gerhard Wolber; Erik J. Sorensen; Matthias Bureik
New luciferin-based probe substrates for human CYP26A1
Biochemistry and Biophysics Reports
2020-12 | Journal article
DOI: 10.1016/j.bbrep.2020.100861
CONTRIBUTORS: Shishir Sharma; Jingyao Liu; Xue Zhang; Sangeeta Shrestha Sharma; Erik J. Sorensen; Matthias Bureik
Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1
Biomolecules
2020-11-06 | Journal article
DOI: 10.3390/biom10111517
CONTRIBUTORS: Yanan Sun; David Machalz; Gerhard Wolber; Maria Kristina Parr; Matthias Bureik
Rapid and convenient biotransformation procedure for human drug metabolizing enzymes using permeabilized fission yeast cells
Analytical Biochemistry
2020-10 | Journal article
DOI: 10.1016/j.ab.2020.113704
CONTRIBUTORS: Shishir Sharma; Pradeepraj Durairaj; Matthias Bureik
A convenient new method for reproducible fed-batch fermentation of fission yeast Schizosaccharomyces pombe
Biotechnology Letters
2020-06-17 | Journal article
DOI: 10.1007/s10529-020-02840-1
CONTRIBUTORS: Alberto Scomparin; Matthias Bureik
Cytochrome P450 expression patterns in human osteoblasts during osteogenic differentiation with or without TNFα treatment
Biopharmaceutics & Drug Disposition
2020-04 | Journal article
DOI: 10.1002/bdd.2227
CONTRIBUTORS: Janak L. Pathak; Lingyu Liu; Yong‐qiang Zhu; Matthias Bureik
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