个人简介
Education Experience :
2000 Ph. D. University of Chicago
1995 M.S. Northern Michigan University
Professional Experience:
2003-2005 Associate Professor The University of Mississippi
2005-2015 Associate professor The University of South Florida
2015- Professor The University of South Florida
2016-2019 Tianjin University,
2020- Zhejiang Sci-tech University
Awards:
Japanese Society for the Promotion of Sciences (JSPS) Fellowship for 2011.
Outstanding Research Achievement Award from The University of South Florida for the Year 2008.
NSF CAREER Award (4/1/2009 – 3/31/2014).
Synlett and Synthesis “Thieme Journal Awardee” for 2009.
NIH National Cancer Institute post-doctoral fellow at MIT (2001-2003).
Received the Lucian F. Hunt award for excellence in chemistry for undergraduates.
研究领域
Our group’s focus has been mainly in the development of new catalytic methodology for organic synthesis. Our group is a recognized leader in the area of asymmetric organocatalysis with chiral phosphoric acids. Our methodology in the formation of aminals, in the reduction of imines, desymmetrization of meso-aziridines, and pinnacol rearrangement, for example, have been highly cited extensively (3,679 citations and H-index of 26). Our methods have used in the synthesis of biologically important targets by others, for example: Benjamin List (JACS, 2008, 15786) and Scott Snyder (Angew. Chem. Int. Ed., 2012, 51, 4080. Our aim has been to develop catalytic variants of existing, important reactions, to offer stereochemical control (regioselective, diastereoselective, or enantioselective) and higher efficiency, thus lower the potential costs to make drug targets. As a result we have been considered one of the leading groups in organocatalysis, especially in chiral phosphoric acid based catalysis. Our work has been recognized with a USA National Science Foundation CAREER award, a Thieme Journal Award, and also I was awarded with a JSPS Fellowship to Japan, a great honor. Additionally, part of our work has been to seek “green” alternatives to existing methods, as the use of organocatalysis avoids the employment of potentially toxic metals in an environmentally benign manner.
近期论文
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Enantioselective Mukaiyama–Michael Reaction of β,γ-Unsaturated α-Keto Esters with Silyl Ketene Acetals Catalyzed by a Chiral Magnesium Phosphate
Hualing He, Xizhe Shen, Xinying Ding, and Jon C. Antilla*
Cite this: Org. Lett. 2023, 25, 5, 782–787
Publication Date:January 26, 2023
https://doi.org/10.1021/acs.orglett.2c04277
Asymmetric Rubottom-Type Oxidation Catalyzed by Chiral Calcium Phosphates
Dr. Hualing He, Dr. K. S. Satyanarayana Tummalapalli, Linfei Zhu, Minglei Chen, Dr. Suvratha Krishnamurthy, Prof. Jon C. Antilla
First published: 21 December 2022 https://doi.org/10.1002/chem.202203720
Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates
Zhenwei Wu, Hualing He, Minglei Chen, Linfei Zhu, Weitao Zheng, Yang Cao*, and Jon C. Antilla*
Cite this: Org. Lett. 2022, 24, 51, 9436–9441
Publication Date:December 15, 2022
https://doi.org/10.1021/acs.orglett.2c03866
Enantioselective Amination of β-Keto Esters Catalyzed by Chiral Calcium Phosphates
Zhenwei Wu, Suvratha Krishnamurthy, K. S. Satyanarayana Tummalapalli, Jun Xu, Dr. Caizhen Yue, Prof. Dr. Jon C. Antilla
First published: 04 May 2022 https://doi.org/10.1002/chem.202200907
Chiral Phosphoric Acid-Catalyzed Enantio- and Diastereoselective Allylboration of Aldehydes with β,γ-Substituted Allylboronates
Jinping Yuan, Pankaj Jain, and Jon C. Antilla*
Cite this: J. Org. Chem. 2022, 87, 12, 8256–8266
Publication Date:June 3, 2022
https://doi.org/10.1021/acs.joc.2c00764
Chiral Calcium Phosphate-Catalyzed Enantioselective Amination of 3-Aryl-2-oxindoles with Dibenzyl Azodicarboxylate
Zhenwei Wu, Suvratha Krishnamurthy, K. S. Satyanarayana Tummalapalli, and Jon C. Antilla*
Cite this: J. Org. Chem. 2022, 87, 12, 8203–8212
Publication Date:May 27, 2022
https://doi.org/10.1021/acs.joc.2c00432
Palladium-Catalyzed Enantioselective C(sp3)–H Arylation of 2-Propyl Azaaryls Enabled by an Amino Acid Ligand
Hong-Liang Li*, Deng-Feng Yang, Hua-Qing Jing, Jon C. Antilla*, and Yoichiro Kuninobu*
Cite this: Org. Lett. 2022, 24, 6, 1286–1291
Publication Date:February 10, 2022
https://doi.org/10.1021/acs.orglett.1c04215
Corrigendum: Palladium‐Catalyzed Secondary C( sp 3 )−H Arylation of 2‐Alkylpyridines
Li Hong‐Liang,Kuninobu Yoichiro
Adv. Synth. Catal. 2020, 362, 2637–2641
10.1002/adsc.202000306
Catalytic Asymmetric C-7 Friedel–Crafts Alkylation/N-Hemiacetalization of 4-Aminoindoles
Hualing He, Yang Cao, Jun Xu, and Jon C. Antilla*
Cite this: Org. Lett. 2021, 23, 8, 3010–3014
Publication Date:April 1, 2021
https://doi.org/10.1021/acs.orglett.1c00699
Imine Amidation Catalyzed by a Chiral VAPOL Calcium Phosphate
Rui Cao and Jon C. Antilla*
Cite this: Org. Lett. 2020, 22, 15, 5958–5962
Publication Date:July 14, 2020
https://doi.org/10.1021/acs.orglett.0c02048
Bi(cyclopentyl)diol-Derived Boronates in Highly Enantioselective Chiral Phosphoric Acid-Catalyzed Allylation, Propargylation, and Crotylation of Aldehydes
Jinping Yuan, Pankaj Jain, and Jon C. Antilla*
Cite this: J. Org. Chem. 2020, 85, 20, 12988–13003
Publication Date:September 22, 2020
https://doi.org/10.1021/acs.joc.0c01646
Catalytic Asymmetric 1,4-Reduction of α-Branched 2-Vinyl-azaarenes by a Chiral SPINOL-Derived Borophosphate
Yang Cao, Shouqi Zhang, and Jon C. Antilla*
Cite this: ACS Catal. 2020, 10, 19, 10914–10919
Publication Date:September 1, 2020
https://doi.org/10.1021/acscatal.0c02563
Catalytic Enantioselective Diels–Alder Reactions of Benzoquinones and Vinylindoles with Chiral Magnesium Phosphate Complexes
Yujia Bai, Jinping Yuan, Xiaoyue Hu, and Jon C. Antilla*
Cite this: Org. Lett. 2019, 21, 12, 4549–4553
Publication Date:May 31, 2019
https://doi.org/10.1021/acs.orglett.9b01437
Catalytic One-Pot Double Asymmetric Cascade Reaction: Synthesis of Chlorinated Oxindoles and Geminal Diamines
Xiantao Fang, Zihang Deng, Wenhua Zheng, and Jon C. Antilla*
Cite this: ACS Catal. 2019, 9, 3, 1748–1752
Publication Date:January 29, 2019
https://doi.org/10.1021/acscatal.8b05019