Antilla, Jon - 天津大学 - 药物科学与技术学院

个人简介

Education Experience ： 2000 Ph. D. University of Chicago 1995 M.S. Northern Michigan University Professional Experience： 2003-2005 Associate Professor The University of Mississippi 2005-2015 Associate professor The University of South Florida 2015- Professor The University of South Florida 2016-2019 Tianjin University, 2020- Zhejiang Sci-tech University Awards： Japanese Society for the Promotion of Sciences (JSPS) Fellowship for 2011. Outstanding Research Achievement Award from The University of South Florida for the Year 2008. NSF CAREER Award (4/1/2009 – 3/31/2014). Synlett and Synthesis “Thieme Journal Awardee” for 2009. NIH National Cancer Institute post-doctoral fellow at MIT (2001-2003). Received the Lucian F. Hunt award for excellence in chemistry for undergraduates.

研究领域

Our group’s focus has been mainly in the development of new catalytic methodology for organic synthesis. Our group is a recognized leader in the area of asymmetric organocatalysis with chiral phosphoric acids. Our methodology in the formation of aminals, in the reduction of imines, desymmetrization of meso-aziridines, and pinnacol rearrangement, for example, have been highly cited extensively (3,679 citations and H-index of 26). Our methods have used in the synthesis of biologically important targets by others, for example: Benjamin List (JACS, 2008, 15786) and Scott Snyder (Angew. Chem. Int. Ed., 2012, 51, 4080. Our aim has been to develop catalytic variants of existing, important reactions, to offer stereochemical control (regioselective, diastereoselective, or enantioselective) and higher efficiency, thus lower the potential costs to make drug targets. As a result we have been considered one of the leading groups in organocatalysis, especially in chiral phosphoric acid based catalysis. Our work has been recognized with a USA National Science Foundation CAREER award, a Thieme Journal Award, and also I was awarded with a JSPS Fellowship to Japan, a great honor. Additionally, part of our work has been to seek “green” alternatives to existing methods, as the use of organocatalysis avoids the employment of potentially toxic metals in an environmentally benign manner.

近期论文

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Enantioselective Mukaiyama–Michael Reaction of β,γ-Unsaturated α-Keto Esters with Silyl Ketene Acetals Catalyzed by a Chiral Magnesium Phosphate Hualing He, Xizhe Shen, Xinying Ding, and Jon C. Antilla* Cite this: Org. Lett. 2023, 25, 5, 782–787 Publication Date:January 26, 2023 https://doi.org/10.1021/acs.orglett.2c04277 Asymmetric Rubottom-Type Oxidation Catalyzed by Chiral Calcium Phosphates Dr. Hualing He, Dr. K. S. Satyanarayana Tummalapalli, Linfei Zhu, Minglei Chen, Dr. Suvratha Krishnamurthy, Prof. Jon C. Antilla First published: 21 December 2022 https://doi.org/10.1002/chem.202203720 Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates Zhenwei Wu, Hualing He, Minglei Chen, Linfei Zhu, Weitao Zheng, Yang Cao*, and Jon C. Antilla* Cite this: Org. Lett. 2022, 24, 51, 9436–9441 Publication Date:December 15, 2022 https://doi.org/10.1021/acs.orglett.2c03866 Enantioselective Amination of β-Keto Esters Catalyzed by Chiral Calcium Phosphates Zhenwei Wu, Suvratha Krishnamurthy, K. S. Satyanarayana Tummalapalli, Jun Xu, Dr. Caizhen Yue, Prof. Dr. Jon C. Antilla First published: 04 May 2022 https://doi.org/10.1002/chem.202200907 Chiral Phosphoric Acid-Catalyzed Enantio- and Diastereoselective Allylboration of Aldehydes with β,γ-Substituted Allylboronates Jinping Yuan, Pankaj Jain, and Jon C. Antilla* Cite this: J. Org. Chem. 2022, 87, 12, 8256–8266 Publication Date:June 3, 2022 https://doi.org/10.1021/acs.joc.2c00764 Chiral Calcium Phosphate-Catalyzed Enantioselective Amination of 3-Aryl-2-oxindoles with Dibenzyl Azodicarboxylate Zhenwei Wu, Suvratha Krishnamurthy, K. S. Satyanarayana Tummalapalli, and Jon C. Antilla* Cite this: J. Org. Chem. 2022, 87, 12, 8203–8212 Publication Date:May 27, 2022 https://doi.org/10.1021/acs.joc.2c00432 Palladium-Catalyzed Enantioselective C(sp3)–H Arylation of 2-Propyl Azaaryls Enabled by an Amino Acid Ligand Hong-Liang Li*, Deng-Feng Yang, Hua-Qing Jing, Jon C. Antilla*, and Yoichiro Kuninobu* Cite this: Org. Lett. 2022, 24, 6, 1286–1291 Publication Date:February 10, 2022 https://doi.org/10.1021/acs.orglett.1c04215 Corrigendum: Palladium‐Catalyzed Secondary C( sp 3 )−H Arylation of 2‐Alkylpyridines Li Hong‐Liang,Kuninobu Yoichiro Adv. Synth. Catal. 2020, 362, 2637–2641 10.1002/adsc.202000306 Catalytic Asymmetric C-7 Friedel–Crafts Alkylation/N-Hemiacetalization of 4-Aminoindoles Hualing He, Yang Cao, Jun Xu, and Jon C. Antilla* Cite this: Org. Lett. 2021, 23, 8, 3010–3014 Publication Date:April 1, 2021 https://doi.org/10.1021/acs.orglett.1c00699 Imine Amidation Catalyzed by a Chiral VAPOL Calcium Phosphate Rui Cao and Jon C. Antilla* Cite this: Org. Lett. 2020, 22, 15, 5958–5962 Publication Date:July 14, 2020 https://doi.org/10.1021/acs.orglett.0c02048 Bi(cyclopentyl)diol-Derived Boronates in Highly Enantioselective Chiral Phosphoric Acid-Catalyzed Allylation, Propargylation, and Crotylation of Aldehydes Jinping Yuan, Pankaj Jain, and Jon C. Antilla* Cite this: J. Org. Chem. 2020, 85, 20, 12988–13003 Publication Date:September 22, 2020 https://doi.org/10.1021/acs.joc.0c01646 Catalytic Asymmetric 1,4-Reduction of α-Branched 2-Vinyl-azaarenes by a Chiral SPINOL-Derived Borophosphate Yang Cao, Shouqi Zhang, and Jon C. Antilla* Cite this: ACS Catal. 2020, 10, 19, 10914–10919 Publication Date:September 1, 2020 https://doi.org/10.1021/acscatal.0c02563 Catalytic Enantioselective Diels–Alder Reactions of Benzoquinones and Vinylindoles with Chiral Magnesium Phosphate Complexes Yujia Bai, Jinping Yuan, Xiaoyue Hu, and Jon C. Antilla* Cite this: Org. Lett. 2019, 21, 12, 4549–4553 Publication Date:May 31, 2019 https://doi.org/10.1021/acs.orglett.9b01437 Catalytic One-Pot Double Asymmetric Cascade Reaction: Synthesis of Chlorinated Oxindoles and Geminal Diamines Xiantao Fang, Zihang Deng, Wenhua Zheng, and Jon C. Antilla* Cite this: ACS Catal. 2019, 9, 3, 1748–1752 Publication Date:January 29, 2019 https://doi.org/10.1021/acscatal.8b05019