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个人简介

教育背景: 天津大学凝聚态物理 硕士(2007),导师:刘昌龙 天津大学材料物理与化学 博士(2012),导师:刘昌龙 美国斯坦福大学 博士后(2013-2015),导师:戴宏杰(Hongjie Dai) 工作经历: 天津大学 教授(2018-) 天津大学 研究员(2016-) 中国医学科学院放射医学研究所(2007-2013) 获奖情况: 国家重点研发计划首席科学家(2021) 国家级青年人才计划项目(2019) 科睿唯安“全球高被引科学家”(Highly Cited Researchers)(2021) 爱思唯尔(Elsevier)中国高被引学者(2020、2021、2022) 中国毒理学会优秀青年科技奖(2022) 天津市杰出青年基金(2021) 天津市131人才计划第二层次(2017) 天津大学北洋青年学者(2016) 天津市青年优秀科技人才计划(2015) 中国医学科学院北京协和医学院‘协和新星’(2012) 正在承担或完成的主要项目: 1.国家重点研发计划,生物与信息融合(BT-IT融合)重大专项,新一代高相容生物植入电极的设计与应用,2363万,首席科学家,在研 2.国家级青年人才计划项目,170万,2020.7-2023.6,主持,在研 3.天津市杰出青年基金,神经分子探针,100万,2021.9-2025.8,主持,在研 4.国家自然科学基金,重大研究计划培育项目,乳腺癌演进和分子分型的红外二区荧光成像,70万,2019.1-2021.12,主持,在研 5.国家自然科学基金,面上项目,有机纳米酶分子的设计及其对外伤性脑损伤的治,55万,2020.1-2023.12.,主持,在研 6.国家自然科学基金,联合基金,电子辐射诱导增强CeO2团簇的电催化性能、催化机理及其在脑损伤中的应用,58万,2020.1-2022.12,主持,在研 7.国家自然科学基金,面上项目,超小Au纳米团簇作为肿瘤放疗增敏剂的研究(基金号: 81471786),73万,2015.1-2018.12,主持,已结题, 8.国家自然科学基金,青年基金,Au纳米颗粒-EGFR抗体靶向肿瘤上皮细胞的放射增敏作用研究(基金号: 81000668),20万,2011.1-2013.12,主持,已结题 9.天津市自然科学基金,重点项目,红外二区荧光探针的设计及其在乳腺癌的早期诊断和多器官转移中的应用,20万,2019.4-2022.3,主持,在研 10.天津大学双一流人才启动经费,主持,结题 11.天津大学北洋青年学者,主持,结题

研究领域

(1) 智能医用材料和纳米医学,主要使用深度学习和密度泛函理论进行超小团簇分子的生物活性设计。 (2) 团簇生物医学。新型生物活性团簇分子的物理化学设计及其在神经系统等重大疾病中应用 (3) 深组织近红外二区(1,100-1700 nm)荧光成像技术在重大疾病方面的应用。新型光学显微镜的构建,深度学习图像处理,红外二区荧光分子探针的设计,及其对重大疾病的病理诊断和监测。 (4) 神经电极的原子分子设计、界面电子输运和重大疾病诊断和干预。

近期论文

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Catalytic nanotechnology of X-ray photodynamics for cancer treatments Biomaterials Science 2023 | Journal article | Author DOI: 10.1039/d2bm01698b Part of ISSN: 2047-4830 Part of ISSN: 2047-4849 CONTRIBUTORS: Gang Zhang; Meili Guo; Huizhen Ma; Junying Wang; Xiaodong Zhang Modulation of the biocatalytic activity and selectivity of CeO2 nanozymes via atomic doping engineering Nanoscale 2023 | Journal article | Author DOI: 10.1039/d2nr05742e Part of ISSN: 2040-3364 Part of ISSN: 2040-3372 CONTRIBUTORS: Shaofang Zhang; Haiyan Ruan; Qi Xin; Xiaoyu Mu; Hao Wang; Xiaodong Zhang LUMO-Mediated Se and HOMO-Mediated Te Nanozymes for Selective Redox Biocatalysis Nano Letters 2023-06-14 | Journal article | Author DOI: 10.1021/acs.nanolett.3c01068 Part of ISSN: 1530-6984 Part of ISSN: 1530-6992 CONTRIBUTORS: Kaijin Liu; Jiaxue Niu; Ling Liu; Fangzhen Tian; Hongmei Nie; Xiaoyu Liu; Ke Chen; Ruoli Zhao; Si Sun; Menglu Jiao et al. Tracking tumor heterogeneity and progression with near‐infrared II fluorophores Exploration 2023-03-16 | Journal article | Author DOI: 10.1002/exp.20220011 Part of ISSN: 2766-2098 Part of ISSN: 2766-2098 CONTRIBUTORS: Qi Xin; Huizhen Ma; Hao Wang; Xiaodong Zhang Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer ACS Nano 2023-03-14 | Journal article | Author DOI: 10.1021/acsnano.2c06629 Part of ISSN: 1936-0851 Part of ISSN: 1936-086X CONTRIBUTORS: Chunhua Zhao; Zekun Liu; Chia-Che Chang; Yi-Chia Chen; Qize Zhang; Xiaodong Zhang; Chrysafis Andreou; Jiadong Pang; Ze-Xian Liu; Di-Yan Wang et al. Activatable NIR-II organic fluorescent probes for bioimaging Theranostics 2022 | Journal article DOI: 10.7150/thno.71359 Part of ISSN: 1838-7640 CONTRIBUTORS: Xiaodong Zhang; Xiaoning Zhang; Shasha Li; Huizhen Ma; Hao Wang; Ruiping Zhang; Xiao-Dong Zhang Airy-like beam-based light-sheet microscopy with improved FOV for zebrafish intracerebral hemorrhage Optics Express 2022 | Journal article DOI: 10.1364/OE.451919 WOSUID: WOS:000793726300064 CONTRIBUTORS: Liu, Pengfei; Chen, Hongyu; Pang, Meijun; Liu, Xiuyun; Wang, Jiwei; Zhang, Xiao-Dong; Ming, Dong Airy beam assisted NIR-II light-sheet microscopy Nano Today 2022-12 | Journal article DOI: 10.1016/j.nantod.2022.101628 Part of ISSN: 1748-0132 CONTRIBUTORS: Xiaodong Zhang; Pengfei Liu; Tianze Shi; Hongwei Li; Hongyu Chen; You Huang; Huizhen Ma; Tianyu Zhu; Rong Zhao; Yuan Li et al. Design of Monovalent Cerium-Based Metal Organic Frameworks as Bioinspired Superoxide Dismutase Mimics for Ionizing Radiation Protection ACS Applied Materials & Interfaces 2022-12-14 | Journal article | Author DOI: 10.1021/acsami.2c17358 Part of ISSN: 1944-8244 Part of ISSN: 1944-8252 CONTRIBUTORS: Ya Liu; He Li; Wei Liu; Jiao Guo; Haiyu Yang; Haikang Tang; Maoye Tian; Hongmei Nie; Xiaodong Zhang; Wei Long Neuron devices: emerging prospects in neural interfaces and recognition Microsystems & Nanoengineering 2022-12-07 | Journal article DOI: 10.1038/s41378-022-00453-4 Part of ISSN: 2055-7434 CONTRIBUTORS: Yang Wang; Shuangjie Liu; Hao Wang; Yue Zhao; Xiao-Dong Zhang Electronic structures and NIR-II optical properties of black phosphorus using first principles Optoelectronics Letters 2022-10 | Journal article DOI: 10.1007/s11801-022-2077-7 Part of ISSN: 1673-1905 Part of ISSN: 1993-5013 CONTRIBUTORS: Xiaofeng Hong; Meili Guo; Ling Liu; Yonghui Li; Xiaodong Zhang Establishing bilateral modulation of radiation induced redox damage via biocatalytic single atom engineering at Au clusters Chemical Engineering Journal 2022-10 | Journal article DOI: 10.1016/j.cej.2022.136793 Part of ISSN: 1385-8947 CONTRIBUTORS: Xiaodong Zhang; Menglu Jiao; Xiaoyu Mu; Si Sun; Haiyu Yang; Lufei Ouyang; Shaofang Zhang; Jiao Guo; Jian Meng; Ya Liu et al. Shaofang Zhang, Yonghui Li, Si Sun, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang & Xiao-Dong Zhang*, Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma, Nature Communications, 2022 (设计了超越天然酶亲和力的单原子纳米酶,唯一通讯作者). https://www.nature.com/articles/s41467-022-32411-z http://news.tju.edu.cn/info/1012/61947.htm Xiaoyu Mu, Junying Wang, Hua He, Qifeng Li, Bing Yang, Junhui Wang, Haile Liu, Yalong Gao, Lufei Ouyang, Si Sun, Qinjuan Ren, Xinjian Shi, Wenting Hao, Qiaoman Fei, Jiang Yang, Lulin Li, Ryan Vest, Tony Wyss-Coray, Jian Luo, and Xiao-Dong Zhang*, An Oligomeric Semiconducting Nanozyme with Ultrafast Electron Transfers Alleviates Acute Brain Injury, Science Advances, 2021 (设计了具有超快电子转移的短聚物纳米酶,可以大缓解急性脑损伤症状,唯一通讯作者)。 https://www.science.org/doi/full/10.1126/sciadv.abk1210 Haile Liu, Yonghui Li, Si Sun, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang & Xiao-Dong Zhang*, Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions, Nature Communications, 2021.(提出团簇酶Clusterzyme的概念,揭示对神经炎症的调控, 入选Nature Communications的Editor Choice,入选ESI高被引,唯一通讯作者),相关学术媒体的报道: http://news.tju.edu.cn/info/1003/54635.htm http://www.xinhuanet.com/tech/2021-01/11/c_1126970056.htm https://www.hubpd.com/c/2021-01-11/985276.shtml Shuangjie Liu, Ling Liu, Yue Zhao, Yang Wang, Yingpeng Wu, Xiao-Dong Zhang*, and Dong Ming*, A High-Performance Electrode Based on van der Waals Heterostructure for Neural Recording, Nano Letters, 2022, 22, 11, 4400–4409 (范德瓦尔斯异质结高性能神经电极). Si Sun, Haile Liu, Qi Xin, Ke Chen, Huizhen Ma, Shuhu Liu, Xiaoyu Mu, Wenting Hao, Shuangjie Liu, Yalong Gao, Yang Wang, Jiahui Pei, Ruoli Zhao, Shaofang Zhang, Xiaoning Zhang, Hao Wang, Yonghui Li*, and Xiao-Dong Zhang*, Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion, Nano Letters, 2021. Yuanyuan Yang, Yingjie Yu, Hao Chen, Xiangxi Meng, Wen Ma, Meng Yu, Ziyuan Li, Changhui Li, Haile Liu, Xiaodong Zhang*, Haihua Xiao*, and Zhiqiang Yu*, illuminating platinum transportation while maximizing therapeutic efficacy by gold nanoclusters via simultaneous near-infrared-i/ii imaging and glutathione scavenging, ACS Nano, 2020. Haile Liu, Guosong Hong, Zhentao Luo, Junchi Chen, Junlei Chang, Ming Gong, Hua He, Jiang Yang, Xun Yuan, Lulin Li, Xiaoyu Mu, Junying Wang, Wenbo Mi, Jian Luo, Jianping Xie*, and Xiao-Dong Zhang *, Atomic Precision Gold Clusters for NIR-II Imaging, Advanced Materials, 2019(原子精度红外二区造影剂的构建及其对神经系统疾病的实时成像,ESI高被引). 学术新闻:http://physics.tju.edu.cn/news/details/10264/ Ruijuan Yan, Si Sun, Jiang Yang, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang,*, Dong Ming,* A Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma, ACS Nano, 2019,(单原子纳米酶神经绷带的构建). 学术新闻:http://news.tju.edu.cn/info/1012/47197.htm Xiaoyu Mu, Hua He, Junying Wang, Wei Long, Qifeng Li, Haile Liu, Yalong Gao, Lufei Ouyang, Qinjuan Ren, Si Sun, Jingya Wang, Jiang Yang, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang*, Wenping Hu, Carbogenic Nanozyme with Ultrahigh RNS Selectivity for Traumatic Brain Injury, Nano Letters, 2019. 学术新闻:http://physics.tju.edu.cn/news/details/10260/ Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, and Xiao-Dong Zhang*, Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury, ACS Nano, 2019. 学术新闻:http://physics.tju.edu.cn/news/details/10260/ Qinglai Yang, Zhuoran Ma, Huasen Wang, Bin Zhou, Shoujun Zhu, Yeteng Zhong, Junying Wang, Hao Wan, Alexander Antaris, Rui Ma, Xiao Zhang, Jingyi Yang, Xiaodong Zhang*, Haitao Sun*, Weiqiang Liu, Yongye Liang*, Hongjie Dai*, Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window, Advanced Materials, 28, 2017 (ESI高被引论文,引用次数=188). Xiao-Dong Zhang, Huasen Wang, Alexander L Antaris, Lulin Li, Shuo Diao, Rui Ma, Andy Nguyen, Guosong Hong, Zhuoran Ma, Joy Wang, Shoujun Zhu, Joseph M Castellano, Tony Wyss-Coray, Yongye Liang*, Jian Luo*, Hongjie Dai*, Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore, Advanced Materials, 28, 2016 (引用次数=247). Xiao-Dong Zhang*, Jinxuan Zhang, Junying Wang, Jiang Yang, Jie Chen, Xiu Shen, Jiao Deng, Dehui Deng, Wei Long, Yuan-Ming Sun, Changlong Liu, Meixian Li*, Highly Catalytic Nanodots with Renal Clearance for Radiation Protection, ACS Nano, 10 (2016) 4511-4519. Xiao-Dong Zhang*, Zhentao Luo, Jie Chen, Xiu Shen, Shasha Song, Yuanming Sun, Saijun Fan, Feiyue Fan, David Tai Leong, Jianping Xie*, Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy. Advanced Materials, 26 (2014) 4565-4568 (ESI高被引论文, 引用次数=365).

学术兼职

中国生物物理学会纳米酶分会委员 中国医药生物技术协会造影技术分会委员 中国生物物理学分子影像学分会委员 中国生物材料学会影像与材料技术分会委员 中国毒理学会放射毒理专业委员会委员 中国抗癌学会纳米肿瘤青年委员会青年委员 中国生物医学工程学会纳米医学与工程分会青年委员 天津生物医学工程学纳米生物医学专委会主任委员 天津市生物医学工程学会理事

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