吴毅 - 天津大学 - 化工学院

个人简介

Yi Wu is an associate professor in the department of synthetic biology at Tianjin University. He leaded the effort to synthesize yeast chromosome 10 in the international Sc2.0 project. He developed a highly efficient mapping strategy called Pooled PCRTag Mapping (PoPM), generalizable to any watermarked synthetic chromosome, to correct unexpected bugs arising during genome synthesis. He also developed new technologies and strategies of SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-Mediated Evolution) to explore the fundamental and industrial application of this system. 学术成就: 2021年国家重点研发计划青年项目首席科学家 2020年入选国家级青年人才计划 2019年天津市自然科学特等奖（排名第六） 2018年入选中国科协青年人才托举工程 2018年天津市青年科技优秀人才 2018年天津大学北洋青年学者 2017年中国科学十大进展 2017年吴瑞奖（Ray Wu基金会）科研项目: 1. 国家重点研发计划绿色生物制造重点专项青年项目 “工业微生物基因组大片段DNA的设计原理与操纵方法” （项目负责人，2021.07-2024.06） 2. 国家重点研发计划合成生物学重点专项项目 “动物染色体设计与合成” （子课题负责人，2020.01-2024.12） 3. 国家自然科学基金委面上项目“CRISPR-Cas9依赖的酵母染色体驱动” （项目负责人，2020.01-2023.12） 4. 中国科协青年人才托举工程 “微生物方法学” （项目负责人，2018-2020） 5. 北洋青年学者项目 “合成基因组学” （项目负责人， 2018-2022）

研究领域

合成生物学（synthetic biology)，合成基因组学(synthetic genomics)，基因组工程(genome engineering)

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Investigation of Genome Biology by Synthetic Genome Engineering Bioengineering 2023-02 | Journal article | Author DOI: 10.3390/bioengineering10020271 CONTRIBUTORS: Hui Zhang; Yao Xiong; Wenhai Xiao; Yi Wu Direct Transfer and Consolidation of Synthetic Yeast Chromosomes by Abortive Mating and Chromosome Elimination ACS Synthetic Biology 2022-10-21 | Journal article | Author DOI: 10.1021/acssynbio.2c00174 Part of ISSN: 2161-5063 CONTRIBUTORS: Zhou Guo; Hongyi Yin; Lu Ma; Jieyi Li; Jiajun Ma; Yi Wu; Ying-Jin Yuan Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE Synthetic and Systems Biotechnology 2022-09 | Journal article | Author DOI: 10.1016/j.synbio.2022.04.003 Part of ISSN: 2405-805X CONTRIBUTORS: Jianping Kang; Jieyi Li; Zhou Guo; Zhou Sijie; Shuxin Su; Wenhai Xiao; Yi Wu; Yingjin Yuan Directed genome evolution driven by structural rearrangement techniques Chemical Society Reviews 2021 | Journal article | Author DOI: 10.1039/d1cs00722j Part of ISSN: 0306-0012 Part of ISSN: 1460-4744 CONTRIBUTORS: Zhou Sijie; Yi Wu; Zexiong Xie; Bin Jia; Ying-Jin Yuan A DNA Inversion System in Eukaryotes Established via Laboratory Evolution ACS Synthetic Biology 2021-09-17 | Journal article | Author DOI: 10.1021/acssynbio.1c00132 Part of ISSN: 2161-5063 Part of ISSN: 2161-5063 CONTRIBUTORS: Peiyan Han; Yuan Ma; Zongheng Fu; Zhou Guo; Jiangnan Xie; Yi Wu; Ying-Jin Yuan Chromosome drives via CRISPR-Cas9 in yeast. Nature communications 2020-08-28 | Journal article DOI: 10.1038/s41467-020-18222-0 PMID: 32859906 PMC: PMC7455567 SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions. ACS synthetic biology 2020-04-17 | Journal article DOI: 10.1021/acssynbio.0c00059 PMID: 32268063 SCRaMbLE generates evolved yeasts with increased alkali tolerance. Microbial cell factories 2019-03-11 | Journal article DOI: 10.1186/s12934-019-1102-4 PMID: 30857530 PMC: PMC6410612 Loss of heterozygosity by SCRaMbLEing. Science China. Life sciences 2019-03-01 | Journal article DOI: 10.1007/s11427-019-9504-5 PMID: 30900161 Heterozygous diploid and interspecies SCRaMbLEing Nature communications 2018 | Journal article DOI: 10.1038/s41467-018-04157-0

学术兼职

合成酵母基因组国际计划（Sc2.0）成员基因组编写国际计划（GP-write）成员中国生物工程学会青年工作委员会委员