董敏 - 天津大学 - 化工学院

个人简介

Employment： 2019-03-01 to present | Professor (Pharmaceutical Engineering) | Tianjin University: Tianjin, CN 2016-03-01 to 2019-01-25 | Research Associate (Chemistry and Chemical Biology) | Cornell University: Ithaca, NY, US 2011-03-01 to 2016-02-29 | Postdoc (Chemistry and Chemical Biology) | Cornell University: Ithaca, NY, US Education： 2006-09-01 to 2009-12-31 | PhD (Health Science Center) | Peking University: Beijing, Beijing, CN 科研项目：国家自然基金面上项目（主持 2019, 2022）天津市自然基金面上项目（主持 2020）科技部合成生物学重点研发项目（参与 2019）国家高层人才项目（主持 2020）天津大学北洋青年学者（主持 2020）天津大学英才教授启动基金（主持 2019）

研究领域

1.金属酶催化的自由基反应的发现、机制研究和功能改造 2.活性天然产物生物合成 3.辅酶因子s-腺苷甲硫氨酸（SAM）相关的化学生物学 4.基于酶机制的抑制剂设计和药物研发

近期论文

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Yu, N.; Zhao H.; Wang, W.; Dong, M.*. Enzymatic fluoroethylation by a fluoroethyl selenium analogue of S-adenosylmethionine. ACS Catalysis. 2024, 14, 6211–6216. Jiang, Y.; Yao, M.; Niu, H.; Wang, W.; He, J.; Qiao, B.; Li, B.; Dong, M.*, Xiao, W.*; Yuan, Y. Enzyme Engineering Renders Chlorinase the Activity of Fluorinase. J Agric Food Chem. 2024, 72, 1203-1212. Wang, W,; Zhao H,; Yu, N,; Chen, F,; Dong, M.*. Stable S-Adenosylmethionine Analogue for Enzymatic Fluoromethylation. ACS Catalysis. 2023, 13, 13729-13734. Huang, R.; Zhi, N,; Yu, L.; Li, Y.; Wu, X.; He, J.; Zhu, H.; Qiao, J.; Liu, X.; Tian, C.; Wang, J *; Dong, M.* Genetically encoded photosensitizer protein reduces iron-sulfur clusters of radical SAM enzymes.ACS Catalysis, 2023, 13, 1240-1245. Zhi, N,; Zhu, H.; Qiao, J.; Dong, M.*. Recent progress in radical SAM enzymes: New reactions and mechanisms. Chin. Sci. Bull. 2022, 67, 1806-1820. Li, Y.; Yao, Y.; Yu, L.; Tian, C.; Dong, M.* Mechanistic investigation of B12-independent glycerol dehydratase and its activating enzyme GD-AE. Chem. Commun., 2022, 58, 2738-2741. Zhou, S.; Chen, X.; Ni, X*.; Liu, Y.; Zhang, H.; Dong, M.*; Xia, H*. Pyridoxal-5´-phosphate-dependent enzyme GenB3 Catalyzes C-3´,4´-dideoxygenation in gentamicin biosynthesis. Microb. Cell. Fact. 2021, 20:65, 1-12. Fenwick, M. K.; Su, Dan.; Dong, M.; Lin, H *; Ealick, S. E.* Structural Basis of the Substrate Selectivity of Viperin. Biochemistry 2020, 59, 652–662. Dong M, Dando EE, Kotliar I, Su X, Dzikovski B, Freed JH, Lin H. The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis. J. Biol. Inorg. Chem. 2019, 24, 777-782. Fenwick, M. K.; Dong, M.; Lin, H.; Ealick, S. E.*. The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. Biochemistry 2019, 58, 4343–4351. Dong, M.; Kathiresan, V.; Fenwick, M. K.; Torelli, A. T.; Zhang, Y.; Caranto, J. D; Dzikovski, B.; Sharma, A.; Lancaster, K. M.; Freed, J. H.; Ealick, S. E.; Hoffman, B. M.; Lin, H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science 2018. 359, 1247-1250. Dong, M.; Zhang, Y.G.; Lin, H. Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods Enzymol. 2018, 606, 421-438. Dong, M.; Zhang, Y.G.; Lin, H. Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis. Biochemistry 2018. 57, 3454–3459. (Invited Perspective). Dong, M.; Horitani, M.; Dzikovski, B.; Freed, J. H.; Ealick, S. E.; Hoffman, B. M.; Lin, H. Substrate-Dependent Cleavage Site Selection by Unconventional Radical S‑Adenosylmethionine Enzymes in Diphthamide Biosynthesis. J. Am. Chem. Soc. 2017. 139, 5680-5683 Dong, M#.; Horitani, M#.; Dzikovski, B.; Pandelia, M. E.; Krebs, C.; Freed, J. H.; Hoffman, B.; Lin, H. Organometallic complex formed by an unconventional radical SAM enzyme. J. Am. Chem. Soc. 2016. 138, 9755-9758. Lin, Z.; Dong, M.; Zhang, Y.; Lee, E.; Lin, H. Cytochrome B5 reductase is a Dph3 reductase required for the tRNA wobble uridine modification. Nat. Chem. Biol. 2016. 12,995–997. Dong, M.; Su, X.; Dzikovski, B. G.; Dando, E. E.; Zhu, X.; Du, J.; Freed, J. H.; Lin, H. Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. J. Am. Chem. Soc. 2014, 136, 1754−7