刘世勇 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

1989.9-1993.7，武汉大学环境科学系环境化学专业本科；1993.9-1996.7，武汉大学化学系高分子化学与物理专业硕士；1996.9-2000.1，复旦大学高分子科学系攻读博士学位；1999.1-1999.6，香港科技大学化学工程系助研；2000.5-2002.5，英国Sussex University化学、物理与环境科学学院博士后；2002.5-2003.10，美国University of Delaware化学工程系博士后；2003.11-12，美国UC Berkeley化学工程系访问学者；2003.12至今，中国科学技术大学高分子科学与工程系教授、博士生导师，合肥微尺度物质科学国家研究中心研究员。2004.10-2014.10任高分子科学与工程系执行主任。2010年起任中科院软物质化学重点实验室主任。2014.10-2019.06任化学与材料科学学院副院长；2019.06起任化学与材料科学学院执行院长。

研究领域

1. 生命同手性起源化学 (Origin-of-Life Chemistry; Biological Homochirality) 2. 螺旋高分子与L-和D-聚多肽螺旋对称性 3. 单一分子量精准聚乙二醇（PEG）及其功能化衍生物和药物制剂 4. 聚多肽/聚酯/聚碳酸酯/聚烯烃精密合成 5. 序列可控数码高分子、测序及防伪加密技术 6. 单组份高性能电子束光刻胶/极紫外光刻胶 7. 前药/聚前药两亲性分子和触发式自降解聚合物 8. 高分子囊泡/反馈与振荡体系 9. 小分子和生物大分子诊疗试剂高效递送 (功能性蛋白/抗体/疫苗) 10.纳米材料蛋白质冠主动精准调控与生物分布定量 11.磁共振/CT/超声成像造影剂、PET成像制剂 12.小分子/高分子光学探针、染料分子工程、多重触发探针、生物正交化学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Q. Q. Shi, H. Yin, R. D. Song, J. Xu, J. J. Tan, X. Zhou, J. Cen, Z. Y. Deng, H. M. Tong, C. H. Cui, Y. F. Zhang, X. P. Li, Z. B. Zhang, S. Y. Liu* “Digital Micelles of Encoded Polymeric Amphiphiles for Direct Sequence Reading and ex Vivo Label-Free Quantification” Nat. Chem. 2023, 15, 257-270. Q. Q. Shi, C. Z. Song, M. L. Chen, J. Xu, S. Q. Zheng, J. J. Tan, J. L. Zhang, N. Wang, J. M. Hu*, S. Y. Liu* “Label-Free Quantification of Digital Nanorods Assembled from Discrete Oligourethane Amphiphiles” J. Am. Chem. Soc. 2023, 145, DOI: 10.1021/jacs.3c07577. C. Z. Song, M. L. Chen, J. J. Tan, J. Xu, Y. B. Zhang, G. Y. Zhang, X. L. Hu*, S. Y. Liu* “Self-Amplified Cascade Degradation and Oxidative Stress via Rational pH Regulation of Oxidation-Responsive Poly(ferrocenes) Aggregates” J. Am. Chem. Soc. 2023, 145, 17755-17766. Q. Q. Shi, Z. B. Zhang*, S. Y. Liu* “Precision Sequence-Defined Polymers: from Sequencing to Biological Functions” Angew. Chem. Int. Ed. 2023, 62, DOI: 10.1002/anie.202313370 (Invited MiniReview). J. Xu+, C. Z. Lv+, Q. Q. Shi, J. L. Zhang, N. Wang, G. Y. Zhang, J. M. Hu*, S. Y. Liu* “Controlled Self-Assembly of Discrete Amphiphilic Oligourethanes with Cascade Self-Immolative Motif” Angew. Chem. Int. Ed. 2023, 62, e202306119. J. Xu, J. J. Tan, C. Z. Song, G. Y. Zhang, X. L. Hu*, S. Y. Liu* “Self-Immolative Amphiphilic Poly(ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy” Angew. Chem. Int. Ed. 2023, 62, e202303829. Q. Q. Shi,+ X. Zhou,+ J. Xu, J. L. Zhang, N. Wang, G. Y. Zhang, J. M. Hu*, S. Y. Liu* “Dendritic Quaternary-Encoded Oligourethanes for Data Encryption” Angew. Chem. Int. Ed. 2023, 62, e202214695. Z. Q. Shen, S. Q. Zheng, Y. M. Fang, G. Y. Zhang, C. Zhu*, S. Y. Liu*, J. M. Hu* “Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near-Infrared (NIR) Light-Triggered Peroxynitrite Generation for Antibacterial Applications” Angew. Chem. Int. Ed. 2023, 62, e202219153. Q. Q. Shi+, Z. Y. Deng+, M. X. Hou+, X. L. Hu*, S. Y. Liu* “Engineering precise sequence-defined polymers for advanced functions” Prog. Polym. Sci. 2023, 141, 101677. A. Z. Shen+, L. Zhang+, Y. B. Xie, X. Y. Zhu, J. M. Hu*, S. Y. Liu* “Engineering Discrete Synthetic Macromolecules for Biomedical Applications” Nano Today 2023, 48, 101728. J. Cen, M. X. Hou, S. Y. Liu* “Discrete Polyethylene glycol Derivatives as a Potent Impetus for Next-Generation Biomedicines” Giant 2023, 15, 100169. M. X. Hou, S. Y. Liu* “Emerging Trends of J-Aggregate Formation within Polymeric Nanoassemblies” Macromol. Chem. Phys. 2023, 224, 202200414. Q. Q. Shi, X. Zhou, J. Xu, Ning Wang, J. L. Zhang, X. L. Hu*, S. Y. Liu* “Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media” Chin. J. Polym. Sci. 2023, 41, 768-777. X. R. Wang, J. M. Hu*, S. Y. Liu* “Overcoming the Dilemma of Permeability and Stability of Polymersomes Through Traceless Cross-Linking” Acc. Chem. Res. 2022, 55, 3404-3416. J. Cen, X. J. Ye, X. Liu, W. H. Pan, L. Zhang, G. Y. Zhang, N. A. He*, A. Z. Shen*, J. M. Hu*, S. Y. Liu* “Fluorinated Copolypeptide-Stabilized Microbubbles with Maleimide-Decorated Surfaces as Long-Term Ultrasound Contrast Agents” Angew. Chem. Int. Ed. 2022, 61, e202209610. Z. H. Chen, S. Q. Zheng, Z. Q. Shen, J. Cheng, S. Y. Shi*, G. Y. Zhang, S. Y. Liu*, J. M. Hu* “Oxygen-Tolerant Photoredox Catalysis Triggers Nitric Oxide Release for Antibacterial Applications” Angew. Chem. Int. Ed. 2022, 61, e202204526. X. Y. Bao, S. Q. Zheng, L. Zhang, A. Z. Shen*, G. Y. Zhang, S. Y. Liu*, J. M. Hu* “Nitric Oxide-Releasing aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities” Angew. Chem. Int. Ed. 2022, 61, e202207250. L. Gao, J. Cheng, Z. Q. Shen, G. Y. Zhang, S. Y. Liu*, J. M. Hu* “Orchestrating Nitric Oxide and Carbon Monoxide Signaling Molecules for Synergistic Treatment of MRSA Infections” Angew. Chem. Int. Ed. 2022, 61, e202112782. G. H. Liu, J. J. Tan, J. Cen, G. Y. Zhang, J. M. Hu*, S. Y. Liu* “Oscillating the Local Milieu of Polymersome Interiors via Single Input-Regulated Bilayer Crosslinking and Permeability Tuning” Nat. Commun. 2022, 13, 585. L. Li, J. Cen, W. J. Li, W. H. Pan, Y. B. Zhang, H. Yin, J. M. Hu*, S. Y. Liu* “A General Strategy Toward the Synthesis of Well-Defined Polypeptides with Complex Chain Topologies” CCS Chem. 2022, 4, 3864-3877. J. M. Hu*, S. Y. Liu* “Emerging Trends of Discrete Poly(ethylene glycol) in Biomedical Applications” Curr. Opin. Biomed. Eng. 2022, 24, 100419. M. L. Chen, X. L. Hu*, S. Y. Liu* “Next Generation Non-Viral Vectors for mRNA Vaccine Delivery” Macromol. Chem. Phys. 2022, 223, 2100443. Y. Y. Mai*, Z. S. An*, S. Y. Liu* “Self-Assembled Materials and Applications” Macromol. Rapid Commun. 2022, 43, 220048. S. Y. Liu* “Challenges and Opportunities of Precision Polymer Chemistry” Chin. J. Polym. Sci. 2022, 40, 1129-1130. J. J. Tan†, Z. Y. Deng†, C. Z. Song, J. Xu, Y. B. Zhang, Y. Yu, J. M. Hu*, S. Y. Liu* “Coordinating External and Built-In Triggers for Tunable Degrada-tion of Polymeric Nanoparticles via Cycle Amplification” J. Am. Chem. Soc. 2021, 143, 14378. Z. Q. Shen, S. Q. Zheng, S. Y. Xiao*, R. A. Shen, S. Y. Liu*, J. M. Hu* “Red Light-Mediated Photoredox Catalysis Enables Self-Reporting Nitric Oxide Release for Efficient Antibacterial Treatment” Angew. Chem. Int. Ed. 2021, 60, 20452. L. Li, J. Cen, W. H. Pan, Y. B. Zhang, X. X. Leng, Z. Q. Tan, H. Yin, S. Y. Liu* “Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions” Research 2021, 9826046. J. J. Tan, J. M. Hu*, S. Y. Liu* “Designing self-propagating polymers with ultrasensitivity through feedback signal amplification” Polym. Chem. 2021, 12, 6230-6241. Z. Y. Deng, Q. Q. Shi, J. J. Tan, J. M Hu*, S. Y. Liu* “Sequence-Defined Synthetic Polymers for New-Generation Functional Biomaterials” ACS Mater. Lett. 2021, 3, 1339. Z. Y. Deng, S. Y. Liu* “Inflammation-Responsive Delivery Systems for the Treatment of Chronic Inflammatory Diseases” Drug Deliv. Transl. Res. 2021, 11, 1475. S. Y. Shi, C. Z. Yao, J. Cen, L. Li, G. H. Liu, J. M. Hu, S. Y. Liu* “High-Fidelity End-Functionalization of Poly(ethylene glycol) Using Stable and Potent Carbamate Linkages” Angew. Chem. Int. Ed. 2020, 59, 18172-18178. C. Z. Yao, Y. M. Li, Z. X. Wang, C. Z. Song, X. L. Hu*, S. Y. Liu* “Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles” ACS Nano 2020, 14, 1919-1935. X. R. Wang, C. Z. Yao, G. Y. Zhang, S. Y. Liu* “Regulating Vesicle Bilayer Permeability and Selectivity via Stimuli-Triggered Polymersome-to-PICsome Transition” Nat. Commun. 2020, 11, 1524. Z. Y. Deng, S. Y. Liu* “Emerging Trends in Solution Self-Assembly of Block Copolymers” Polymer 2020, 207, 122914 Z. X. Ding, J. Cen, Y. Wu, K. Zhong, G. H. Liu, J. M. Hu*, S. Y. Liu* “Self-Immolative nanoparticles for stimuli-triggered activation, covalent trapping and accumulation of in situ generated small molecule theranostic fragments” Giant 2020, 1, 100012. Z. Y. Deng, Z. Y. Deng, S. Y. Liu* “Controlled Drug Delivery with Nanoassemblies of Redox-Responsive Prodrug and Polyprodrug Amphiphiles” J. Controlled Release 2020, 326, 276-296 (Invited Review Article) J. M. Hu, S. Y. Liu* “Autonomous Self-Healing to Combat Insulation Failure” Matter 2020, 2, 288-289 (Preview). J. M. Hu*, S. Y. Liu* “Modulating Intracellular Oxidative Stress via Engineered Nanotherapeutics” J. Controlled Release 2020, 320, 333-343 (Invited Review Article). Z. Y. Deng, J. M. Hu, S. Y. Liu* “Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications” Macromol. Rapid Commun. 2020, 41, 1900531 (Invited Review Article). S. Y. Liu* “Digital Dendrimer: A New Horizon of Information-Containing Polymers” Sci. China Chem. 2019, 62, 925-926 (Highlight). C. Z. Yao, X. R. Wang, J. M. Hu, S. Y. Liu* “Cooperative Modulation of Bilayer Permeability and Microstructures of Polymersomes” Acta Polym. Sinica 2019, 50, 553-566.