严晓文 - 厦门大学 - 化学化工学院

个人简介

副教授、特任研究员（厦门大学化学系 2019.04–至今）博士后（加拿大阿尔伯塔大学医学院2013–2019）理学博士（厦门大学化学系分析化学专业 2007–2012）理学学士（厦门大学化学系化学生物学专业 2003–2007）

研究领域

色谱质谱光谱多维分析、生物分子相互作用、定量蛋白质组学、多功能分子探针设计合成、生物偶联技术、核酸分析、基因编辑、药物输送

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Yan, X. W.; Le, X. C.*; Zhang, H. Q.* Antibody-bridged beacon for homogeneous detection of small molecules. Anal. Chem. 2018, 90, 9667–9672. 2. Yan, X. W.; Zhang, H. Q.; Wang, Z. X.; Peng, H. Y.; Tao, J.; Li X. F.; Le, X. C.* Quantitative synthesis of protein-DNA conjugates with 1:1 stoichiometry. Chem. Commun. 2018, 54, 7491–7494. 3. Yan, X. W.; Li, J. H.; Liu, Q. Q.; Peng, H. Y.; Popowich, A.; Wang, Z. X.; Li, X. F.; Le, X. C.* p-Azidophenylarsenoxide: An arsenical "bait" for the in-situ capture and identification of cellular arsenic-binding proteins. Angew. Chem. Int. Ed. 2016, 55, 14051–14056. 4. Yan, X. W.; Li, Z. X.; Liang, Y.; Yang, L. M.; Zhang, B.; Wang, Q. Q.* A chemical “hub” for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry. Chem. Commun. 2014, 50, 6578–6581. 5. Yan, X. W.; Yang, L. M.; Wang, Q. Q.* Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges. Anal. Bioanal. Chem. 2013, 405, 5663–5670. 6. Yan, X. W.; Luo, Y. C.; Zhang, Z. B.; Li, Z. X.; Luo, Q.; Yang, L. M.; Zhang, B.; Chen, H. F.; Bai, P. M.; Wang, Q. Q.* Europium-labeled activity-based probe through click chemistry: absolute serine protease quantification using 153Eu isotope dilution ICP/MS. Angew. Chem. Int. Ed. 2012, 51, 3358–3363. 7. Yan, X. W.; Yang, L. M.; Wang, Q. Q.* Lanthanide-coded protease-specific peptide–nanoparticle probes for label-free multiplex protease assay using element mass spectrometry: a proof-of-concept study. Angew. Chem. Int. Ed. 2011, 50, 5130–5133. 8. Yan, X. W.; Xu, M.; Yang, L. M.; Wang, Q. Q.* Absolute quantification of intact proteins via 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimido-ethylacetamide-europium labeling and HPLC coupled with species-unspecific isotope dilution ICPMS. Anal. Chem. 2010, 82, 1261–1269.