顾颖 - 厦门大学 - 公共卫生学院

个人简介

1996年，厦门大学生物学专业，学士学位； 2006年，厦门大学生化与分子生物学专业/细胞生物学专业，博士学位； 2006年，厦门大学生命科学学院助理教授、硕士生导师； 2013年，厦门大学生命科学学院副教授；

研究领域

1、抗病毒的单抗筛选：利用细胞模型和重组抗原等进行抗病毒的单抗筛选，如HIV中和单抗、识别免疫优势表位单抗等的筛选。 2、基于表位的抗原研究：利用基因工程重组技术表达获得含有功能表位的抗原或颗粒化抗原。 3、功能性表位研究：应用生物传感器、分析超离、微量热等方法研究抗原-抗体的相互作用，尝试解析免疫复合物的空间结构，鉴定功能性表位的特征。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J, Ng MH, Hew CL, Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody. Cell Res. 2015 May;25(5):604-20. 2、Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, Xin L, Wei M, Kong Z, Yu H, Gu Y, Zhang J, Li S, Xia N. Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody. PLoS One. 2015 Apr 23;10(4):e0123944. 3、Gu Y, Cao F, Wang L, Hou W, Zhang J, Hew CL, Li S*, Yuan YA*, Xia N*. Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr 19;8(4):e61314. 4、Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, Zhang J,Li S*, Xia N*.Hepatitis Evirus capsid protein assembles in 4M urea in the presence of salts.Protein Sci. 2013 Mar;22(3):314-26. 5、Gu Y, Hou W, Xu C, Li S, Shih JW, Xia N*. The enhancement of RNAi against HIV in vitro and in vivo using H-2K(k) protein as a sorting method. J Virol Methods. 2012 Jun;182(1-2):9-17. 6、Shen L1, Gu Y 1, Sun L, Yang Y, Wang F, Li Y, Bi S*. Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China. J Med Virol. 2012 Mar;84(3):445-9. (co-1st) 7、Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL,Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization and genotype specificity of hepatitis E virus. ProcNatl Acad Sci U S A. 2011 Jun 21;108(25):10266-71. 8、Yu H,Li S*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N*. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model. 2011 May;17(5):987-95. 9、Zheng Z, Luo W*, Song H, Chen Y, Xiong J, Chen Y, Gu Y, Chen H, Shih JW, Zhang J, Xia N*. Antibody reactivity of conformational peptide mimics of a conserved H5N1 neutralization site in different fusion proteins. Arch Virol. 2010;155(1):19-26. 10、Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction.PLoS Pathog. 2009 Aug;5(8):e1000537. 11、Xu CY, Gu Y*, Hou WH, Que YQ, Gao SG, Cheng T, Xia NS*. Tetracysteine as a Reporter for Gene Therapy. Biomed Environ Sci. 2009 Dec;22(6):496-501. 12、Li S, Zhang J, He Z, Gu Y, Liu R, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid.J Biol Chem. 2005 Feb 4;280(5):3400-6. 13、Yang HJ, Chen M, Cheng T, He SZ, Li SW, Guan BQ, Zhu ZH, Gu Y, Zhang J, Xia NS.Expression and immunoactivity of chimeric particulate antigens of receptor binding site-core antigen of hepatitis B virus. World J Gastroenterol. 2005 Jan 28;11(4):492-7. 14、Zhang J, Gu Y, Ge SX, Li SW, He ZQ, Huang GY, Zhuang H, Ng MH, Xia NS. Analysis of hepatitis E virus neutralization sites using monoclonal antibodies directed against a virus capsid protein. Vaccine. 2005 Apr 22;23(22):2881-92. 15、Gu Y, Zhang J, Wang YB, Li SW, Yang HJ, Luo WX, Xia NS*. Selection of a peptide mimicking neutralization epitope of hepatitis E virus with phage peptide display technology. World J Gastroenterol. 2004 Jun 1;10 (11):1583-8. 16、Zhang J, Ge SX, Huang GY, Li SW, He ZQ, Wang YB, Zheng YJ, Gu Y, Ng MH, Xia NS. Evaluation of antibody-based and nucleic acid-based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model. J Med Virol. 2003 Dec;71(4):518-26.