林育纯 - 厦门大学 - 公共卫生学院

个人简介

学术简历 2013.03 - 至今厦门大学公共卫生学院副教授 2012.06 - 2013.03中山大学公共卫生学院副教授 2007.09 - 2011.06 中山大学公共卫生学院卫生毒理学专业，获医学博士学位 2003.09 - 2006.06中山大学公共卫生学院卫生毒理学专业，获医学硕士学位 1999.11 - 2012.05 中山大学公共卫生学院讲师 1991.07 - 1999.11 福建医科大学公共卫生学院助教、讲师 1986.09 - 1991.07福建医科大学公共卫生学院预防医学专业本科，获医学学士学位

研究领域

研究方向：分子与遗传毒理学。主要研究内容：(1) 基因多态性功能分析； (2)致癌作用的表观遗传机制； (3)毒性通路的PP2A调控机制。

近期论文

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1.Liao K, Xia B, Zhuang QY, Hou MJ, Zhang YJ, Luo B, Qiu Y, Gao YF, Li XJ, Chen HF, Ling WH, Huang YJ, He CY, Lin YC* , Lin ZN*. Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway. Theranostics, 2015;5(3):302-21. 2.Chen HF, Mai JR, Wan JX, Gao YF, Lin LN, Wang SZ, Chen YX, Zhang CZ, Zhang YJ, Xia B, Liao K, Lin YC*, Lin ZN*. Role of a novel functional variant in the PPP2R1Apromoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma. PLoS One.2013;8(3):e59574. 3.Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN*, Lin YC*. Identification and functional analysis of variant haplotypes in the 5’-flanking region of protein phosphatase 2A-Bd gene. PLoS One. 2012;4(7):e35524. 4.Lin ZN, Lin YC(co-first author), Zhang X, Kadlubar S, Tuo J, Green B, Deng H, Ning B. Differential promoter activities of functional haplotypes in the 5'-flanking region of human sulfotransferase1A1. J Biochem Mol Toxicol. 2012;26(10):422-428. 5.Lin YC, Chen HF, Lin LN, Luo J, Li W, Zhang SJ, Li XJ, Hu YM, Chen YX, Chen W, Lin ZN*. Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter. Mutat Res.2011;716(1-2):66-75. 6.Chen LP, Lai YD, Li DC, Zhu XN, Yang P, Li WX, Zhu W, Zhao J, Li XD, Xiao YM, Zhang Y, Xing XM, Wang Q, Zhang B,Lin YC, Zeng JL, Zhang SX, Liu CX, Li ZF, Zeng XW, Lin ZN, Zhuang ZX, Chen W. α4 is highly expressed in carcinogen-transformed human cells and primary human cancers. Oncogene. 2011;30(26):2943-2953. 7.Wang Q, Li DC, Li ZF, Liu CX, Xiao YM, Zhang B, Li XD, Zhao J, Chen LP, Xing XM, Tang SF, Lin YC, Lai YD, Yang P, Zeng JL, Xiao Q, Zeng XW, Lin ZN, Zhuang ZX, Zhuang SM, Chen W. Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen. Oncogene. 2011;30(36):3875-3886. 8.Pang Y, Li W, Ma R, Ji W, Wang Q, Li D, Xiao Y, Wei Q, Lai Y, Yang P, Chen L, Tang S, Lin Y, Zhuang Z, Zheng Y, Chen W. Development of human cell models for assessing the carcinogenic potential of chemicals. Toxicol Appl Pharmacol. 2008;232(3):478-86.