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个人简介

主要工作及教育经历: 2013年01月-至今,厦门大学,公共卫生学院,副教授 2011年-2013年,英国爱丁堡大学,医学与兽医学院/罗斯林研究所,博士后研究员(PostDoc Research Fellow) 2009年-2010年,英国格拉斯哥大学,生命科学与医学院/微生物系,博士后研究助理/副研究员(PostDoc Research Assistant/Associate) 2006年03月-2006年06月,美国麻省医学院,分子生物与微生物系,访问学者(Visiting Research Associate) 2005年-2009年,英国爱丁堡大学,医学与兽医学院/罗斯林研究所,博士; 2003年-2004年,英国爱丁堡大学,医学与兽医学院,研究型硕士; 1997年-2001年,上海大学生命科学学院生物工程系,学士。

研究领域

从事细菌病原学方面的研究,主要研究领域为病原细菌的分子致病机制及病原宿主互作

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Wang, D., Zetterstrom, C. E., Gabrielsen, M., Beckham, K. S., Tree, J. J., Macdonald, S. E., Byron, O., Mitchell, T. J., Gally, D. L., Herzyk, P., Mahajan, A., Uvell, H., Burchmore, R., Smith, B. O., Elofsson, M. & Roe, A. J. Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. J Biol Chem 286, 29922-31 (2011). (Faculty of 1000 “推荐文章”, Faculty of 1000, 04 Aug 2011. F1000.com/12444963; http://f1000.com/12444963) 2. Wang, D., Roe, A. J., McAteer, S., Shipston, M. J. & Gally, D. L. Hierarchal type III secretion of translocators and effectors from Escherichia coli O157:H7 requires the carboxy terminus of SepL that binds to Tir. Mol Microbiol 69, 1499-512 (2008). 3. Gabrielsen, M.#, Zetterstrom, C. E.#, Wang, D.#, Beckham, K. S.#, Elofsson, M., Isaacs, N. W. & Roe, A. J. Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 1606-9 (2010).(#:共同第一作者) 4. Tree, J. J., Wang, D., McInally, C., Mahajan, A., Layton, A., Houghton, I., Elofsson, M., Stevens, M. P., Gally, D. L. & Roe, A. J. Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7. Infect Immun 77, 4209-20 (2009). 5. Tahoun, A., Mahajan, S., Paxton, E., Malterer, G., Donaldson, D. S., Wang, D., Tan, A., Gillespie, T. L., O'Shea, M., Roe, A. J., Shaw, D. J., Gally, D. L., Lengeling, A., Mabbott, N. A., Haas, J. & Mahajan, A. Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion. Cell Host Microbe 12, 645-56 (2012). 6. Tree, J. J., Wolfson, E. B., Wang, D., Roe, A. J. & Gally, D. L. Controlling injection: regulation of type III secretion in enterohaemorrhagic Escherichia coli. Trends Microbiol 17, 361-70 (2009). 7. Holmes, A., Lindestam Arlehamn, C. S., Wang, D., Mitchell, T. J., Evans, T. J. & Roe, A. J. Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2. PLoS One 7, e33408 (2012). 8. Roe, A. J. Tysall, L., Dransfield, T., Wang, D., Fraser-Pitt, D., Mahajan, A., Constandinou, C., Inglis, N., Downing, A., Talbot, R., Smith, D. G. & Gally, D. L. Analysis of the expression, regulation and export of NleA-E in Escherichia coli O157:H7. Microbiology 153, 1350-60 (2007). 9. Gabrielsen, M., Beckham, K. S., Feher, V. A., Zetterstrom, C. E., Wang, D., Muller, S., Elofsson, M., Amaro, R. E., Byron, O. & Roe, A. J. Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PLoS One 7, e32217 (2012). 10. Nart, P., Holden, N., McAteer, S. P., Wang, D., Flockhart, A. F., Naylor, S. W., Low, J. C., Gally, D. L. & Huntley, J. F. Mucosal antibody responses of colonized cattle to Escherichia coli O157-secreted proteins, flagellin, outer membrane proteins and lipopolysaccharide. FEMS Immunol Med Microbiol 52, 59-68 (2008).

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