李少伟 - 厦门大学 - 公共卫生学院

个人简介

简历 (Education and Work experience)： 1998年，厦门大学生物化学专业，学士学位； 2003年，厦门大学生化与分子生物学/动物学专业，博士学位； 2003年，厦门大学生命科学学院讲师； 2006年，厦门大学生命科学学院副教授； 2011年，厦门大学生命科学学院/公共卫生学院教授、博士生导师。

研究领域

基因工程疫苗研究与开发重要传染病病毒免疫表位的结构和功能研究基于结构的分子模拟和分子设计

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J,Ng MH, Hew CL, Li S*, Xia N*,Sivaraman J*.Structural basis for theneutralization of hepatitis E virus by a cross-genotype antibody.Cell Res. 2015 May;25(5): 604-20. 2.Li S, Zhang J, Xia N*. Lessons from hepatitis E vaccinedesign.Curr Opin Virol. 2015Apr;11:130-136. 3.Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, XinL, Wei M, Kong Z, Yu H, Gu Y, Zhang J, LiS*, Xia N*. Identification of Broad-GenotypeHPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-NeutralizingAntibody.PLoS One. 2015 Apr23;10(4):e0123944. 4.Li SW, Zhao Q, Wu T*, Chen S, Zhang J, Xia NS. The developmentof a recombinant hepatitis E vaccine HEV 239.Hum Vaccin Immunother. 2015;11(4):908-14. 5.Gu Y, Cao F,Wang L, Hou W, Zhang J, Hew CL,Li S*, Yuan YA*, Xia N*. Structure of aNovel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-SpectrumAntibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr19;8(4):e61314. 6.Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, ZhangJ,Li S*, Xia N*.Hepatitis E virus capsid protein assembles in 4Murea in the presence of salts.ProteinSci. 2013 Mar;22(3):314-26. 7.Tang X, YangC, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL,Li S*, Xia N*,Sivaraman J*. Structural basis for the neutralization and genotype specificityof hepatitis E virus. ProcNatlAcad Sci U S A. 2011 Jun 21;108(25):10266-71.Epub 2011 Jun 3. 8.Yu H,LiS*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N.Homology model and potential virus-capsid binding site of a putative HEVreceptor Grp78. J Mol Model. 2011May;17(5):987-95. Epub 2010 Jul 14. 9.Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H,Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus CapsidProtein E2s Domain is Essential for Virus-Host Interaction.PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7. 10.Yang K,LiS*, He F, Zhang J, Wei M, Pan H, Yang C, Xiong J, Zhang J, Xia N.Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutantfrom Saccharomyces Cerevisiae.JBiosci Bioeng. 2009 Jul;108(1):5-10. 11.Yan Y,LiS*, Yang C, Luo W, Wang M, Chen Y, Luo H, Wu T, Zhang J, Xia N.Prediction of a common neutralizing epitope of H5N1 avian influenza virus by insilico molecular docking.ChineseScience Bulletin. 2008.53(1). 12.Li S, Zhang J, Li Y, Ou S, Huang G, He Z, Ge S, Xian Y, PangS, Ng M, Xia N*. A bacterially expressed particulate hepatitis E vaccine:antigenicity, immunogenicity and protectivity on primates. Vaccine.2005 Apr 22;23(22):2893-2901. 13.Li S, Zhang J, He Z, Gu Y, LiuR, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactionsinvolved in the assembly of hepatitis E virus capsid.J Biol Chem. 2005Feb 4;280(5):3400-6. Epub 2004 Nov 22.