林忠宁 - 厦门大学 - 公共卫生学院

个人简介

学术简历 2013.03 - 至今厦门大学公共卫生学院教授/博士生导师 2007.12 - 2013.03　中山大学公共卫生学院教授/博士生导师 2002.05 - 2007.12中山大学公共卫生学院副教授/硕士生导师 2004.05 - 2005.11美国国家毒理研究中心(NCTR, FDA, USA) 访问学者 2002.09 - 2006.06中山大学公共卫生学院卫生毒理学专业，获医学博士学位 2000.06 - 2000.12新加坡国立大学(COFM, NUS)高级访问学者 1998.07 - 2002.05中山(医科)大学公共卫生学院助教、讲师 1995.09 - 1998.06中山医科大学公共卫生学院环境卫生学专业，获医学硕士学位 1991.07 - 1995.08 福建医科大学公共卫生学院助教 1986.09 - 1991.07福建医科大学公共卫生学院预防医学专业本科，获医学学士学位

研究领域

研究方向：环境卫生与卫生毒理学主要研究内容：(1) 环境因素与健康； (2) 毒性作用的信号通路调控机制； (3) 基因多态性功能分析； (4) 转化毒理学。

近期论文

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1.Liao K, Xia B, Zhuang QY, Hou MJ, Zhang YJ, Luo B, Qiu Y, Gao YF, Li XJ, Chen HF, Ling WH, Huang YJ, He CY, Lin YC* , Lin ZN*. Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway. Theranostics, 2015;5(3):302-21. 2.Chen HF, Mai JR, Wan JX, Gao YF, Lin LN, Wang SZ, Chen YX, Zhang CZ, Zhang YJ, Xia B, Liao K, Lin YC, Lin ZN*. Role of a novel functional variant in the PPP2R1Apromoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma. PLoS One.2013;8(3):e59574. 3.Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN*, Lin YC*. Identification and functional analysis of variant haplotypes in the 5’-flanking region of protein phosphatase 2A-Bd gene. PLoS One. 2012;4(7):e35524. 4.Lin ZN, Lin YC, Zhang X, Kadlubar S, Tuo J, Green B, Deng H, Ning B. Differential promoter activities of functional haplotypes in the 5'-flanking region of human sulfotransferase1A1. J Biochem Mol Toxicol. 2012;26(10):422-8. 5.Lin YC, Chen HF, Lin LN, Luo J, Li W, Zhang SJ, Li XJ, Hu YM, Chen YX, Chen W, Lin ZN*. Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter. Mutat Res.2011;716(1-2):66-75. 6.Lin ZN, Zhang XM, Tuo JS, Guo YL, Green B, Chan CC, Tan W, Huang Y, Ling WH, Kadlubar FF, Lin DX, Ning BT. Variant of the Cockayne Syndrome B gene ERCC6 confers risk of lung cancer. Human Mutation. 2008;29(1):113-22. 7.Zhang SY, Lin ZN(co-first author), Yang CF, Shi XL, Ong CN, Shen HM. Suppressed NF-kB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-α-induced apoptosis in human cancer cells. Carcinogenesis. 2004;25(11):2191-2199. 8.Zhang X, Lin J, Wu X, Lin Z, Ning B, Kadlubar S, Kadlubar FF. Association between GSTM1 copy number, promoter variants and susceptibility to urinary bladder cancer. Int J Mol Epidemiol Genet. 2012;3(3):228-236. 9.Chen LP, Lai YD, Li DC, Zhu XN, Yang P, Li WX, Zhu W, Zhao J, Li XD, Xiao YM, Zhang Y, Xing XM, Wang Q, Zhang B,Lin YC, Zeng JL, Zhang SX, Liu CX, Li ZF, Zeng XW, Lin ZN, Zhuang ZX, Chen W. α4 is highly expressed in carcinogen-transformed human cells and primary human cancers. Oncogene. 2011;30(26):2943-2953. 10.Wang Q, Li DC, Li ZF, Liu CX, Xiao YM, Zhang B, Li XD, Zhao J, Chen LP, Xing XM, Tang SF, Lin YC, Lai YD, Yang P, Zeng JL, Xiao Q, Zeng XW, Lin ZN, Zhuang ZX, Zhuang SM, Chen W. Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen. Oncogene. 2011;30(36):3875-3886. 11.Pan S, Yang X, Yang L, Wei Q, Yang Y, Xu G, Lin Z, Huang J. Human GSTs polymorphisms in the Hakka population of south China and their associations with family history of several chronic diseases.Biomed Environ Sci. 2011;24(5):491-498.