个人简介

BSc Laurentian University (1985) PhD University of Ottawa (1989)

研究领域

Organic and Biological Chemistry Synthetic and medicinal organic chemistry Symetrical synthesis synthetic organic chemistry Asymmetric methodology Organo-catalysis tetrasubstituted olefins

Our group is interested in asymmetric catalysis by organic molecules. We have developed a new class of hydrazide-based catalyst that catalyzes Diels-Alder ring closure in aqueous media. These compounds catalyze a variety of asymmetric transformations with high yields. We are working to expand and explore the chemistry of these novel and highly effective organo-catalysts. We are also applying high throughput methods to the discovery of novel catalytic entities. To more rapidly identify interesting compounds we are developing methods to rapidly identify enantioselective processes that can be applied to high throughput screening. We are using this technology to develop novel catalysts and reactions.

近期论文

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44. Lemay, M.; Trant, J. and Ogilvie, W.W. �Hydrazide-catalyzed 1,3-dipolar nitrone cycloadditions�, Tetrahedron, 2007, 63, 11644-11655. 43. Flynn, A.B. and Ogilvie, W.W. �Stereocontrolled Synthesis of Tetrasubstituted Olefins� Chemical Reviews, 2007, 107, 4698-4745. 42. Goudreau, N.; Cameron, D.R.; D�ziel, R.; Hach�, B.; Jakaliana, A.; Malenfant, E.; Naud, J.; Ogilvie, W.W.; O�Meara, J.; White, P.W.; Yoakim, C. �Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1�E2 protein�protein interaction: A combined medicinal chemistry, NMR and computational chemistry approach� Bioorganic & Medicinal Chemisty, 2007, 2690-2700. 41. Ho, M.N.; Lemay, A.B.; and Ogilvie, W.W. �Single Isomer Iodochlorination of Alkynes and Chlorination of Alkenes Using Tetrabutylammonium Iodide and Dichloroethane� Journal of Organic Chemistry, 2007, 72, 977-983. 40. Lemay, M., Aumand, L. and Ogilvie, W.W. �Design of a Conformationally Rigid Hydrazide Organic Catalyst�, Advanced Synthesis and Catalysis, 2007, 349, 441-447. 39. Lemay, M. and Ogilvie, W.W. �Mechanistic Studies of Hydrazide Catalyzed Enantioselective Diels-Alder Reactions�, Journal of Organic Chemistry, 2006, 71, 4663-4666. 38. Lemay, A.B.; Vulic, K.S.; and Ogilvie, W.W. �Single Isomer Tetrasubstituted Olefins from Regioselective and Stereospecific Palladium-Catalyzed Coupling of -Chloro--Iodo--Unsaturated Esters� Journal of Organic Chemistry, 2006, 71, 3615-3618. 37. Lemay, M. and Ogilvie, W.W. �Aqueous Enantioselective Organocatalytic Diels-Alder Reactions Employing Hydrazide Catalysts. A new Scaffold for Organic Acceleration.� Organic Letters, 2005, 7, 4141-4144. 36. O�Meara, J.A.; Yoakim, C; Bonneau, P.R.; B�s, M.; Cordingley, M.G.; D�ziel, R.; Doyon, L.; Duan, J.; Garneau, M.; Guse, I.; Landry, S.; Malenfant, E.; Naud, J.; Ogilvie, W.W; Thavonekham, B.; Simoneau, B. Journal of Medicinal Chemistry, 2005, 48, 5580-5588 35. Charbonneau, V. and Ogilvie, W.W. �High Throughput Screening Methods for Asymmetric Synthesis�, Mini-Reviews in Organic Chemistry. 34. Yoakim, C.; Bonneau, P.R; D�ziel, R.; Doyon, L.; Duan, J.; Guse, I.; Landry, S.; Malenfant, E.; Naud, J.; Ogilvie, W.W.; O�Meara, J.A.; Plante, R.; Simoneau, B.; Thavonekham, B.; B�s, M.; Cordingley, M. �Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyl-dipyridodiazepinone derivatives� Bioorganic & Medicinal Chemistry Letters, 2004, 14, 739-742 33. Davidson, W.; McGibbon, G. A.; White, P. W.; Yoakim, C.; Hopkins, J. L.; Guse, I.; Hambly, D. M.; Frego, L.; Ogilvie, W.W.; Lavallee, P.; Archambault, J. �Characterization of the Binding Site for Inhibitors of the HPV11 E1-E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry�, Analytical Chemistry, 2004, 76, 2095-2102. 32. Beaulieu, P.; Ogilvie, W.W. �A sequential Claisen/ring closing metathesis approach to the synthesis of spirocyclic cyclopentanes and cyclohexanes� Tetrahedron Letters, 2003, 44, 8883-8885. 31. Yoakim, C.; Goudreau, N.; McGibbon, G.A.; O�Meara, J.; White, P.W.; Ogilvie, W.W. �Structure Elucidation of the First Inhibitors of Human Papillomavirus Type 11 E1-E2 Protein-Protein Interaction.� Helvetica Chimica Acta, 2003, 86, 3427-3444. 30. Yoakim, C.; Ogilvie, W.W.; Goudreau, N.; Naud, J.; Hach�, B.; O�Meara, J.A.; Cordingley, M.G.; Archambault, J.; White, P. �Discovery of the First Series of Inhibitors of Human Papillomavirus Type 11: Inhibition of the Assembly of the E1�E2�Origin DNA Complex�, Bioorganic & Medicinal Chemistry Letters, 2003, 13, 2539-2541. 29. White, P.W.; Titolo, S.; Brault, K.; Thauvette, L.; Pelletier, A.; Welchner, E.; Bourgon, L.; Doyon, L.; Ogilvie, W.W.; Yoakim, C.; Cordingley, M.G.; Archambault, J. �Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction� Journal of Biological Chemistry, 2003, 278, 26765-26772. 28. Guindon, Y.; Ogilvie, W.W.; Bordeleau, J.; Cui, W.L.; Durkin, K.; Gorys, V.; Juteau, H. Lemieux, R.; Liotta, D.; Simoneau, B.; Yoakim, C. �Opening of Tartrate Acetals Using Dialkylboron Bromide. Evidence for Stereoselectivity Downstream from Ring Fission.� Journal of the American Chemical Society, 2003, 125, 428-436. 27. Ogilvie, W.W. "Non-Nucleoside Inhibitors of the Human Cytomegalovirus" Current Medicinal Chemistry � Anti-Infective Agents, 2002, 1, 177-191. 26. Guindon, Y.; Soucy, F.; Yoakim, C.; Ogilvie, W.W.; Plamondon, L. "Diastereoselective Synthesis of 2,3,5-trisubstituted Tetrahydrofurans via Cyclofunctionalization Reactions." Journal of Organic Chemistry, 2001, 66, 8992-8996. 25. Simoneau, B.; Pavall�e, P.; Bailey, M.; Duceppe, J.-S.; Grand-Ma�tre, C.; Grenier, L.; Ogilvie, W.W.; Poupart, M.-A.; Thavonekham, B. �Stereoselective Synthesis of Renin Inhibitor BILA 2157 BS.� Canadian Journal of Chemistry, 2000, 739-748. 24. Gu�rin, B.; Chabot, C.; Mackintosh, N.; Ogilvie, W.; Guindon, Y. �Free Radicals and Lewis Acid. Chelation-Controlled Radical Allylations of Substituted a-Halo- or a-Phenylseleno-b-Alkoxy Esters. The Endocyclic Effect.� Canadian Journal of Chemistry, 2000, 852-867 23. Bonneau, P.R.; Hasani, F.; Plouffe, C.; Malenfant, E.; LaPlante, S.R.; Guse, I.; Ogilvie, W.W.; Plante, R.; Davidson, W.C.; Hopkins, J.L.; Morelock, M.M.; Cordingley, M.G.; D�ziel, R. �Inhibition of Human Cytomegalovirus Protease by Monocyclic b-Lactam Derivatives: Kinetic Characterization Using a Fluorescent Probe� Journal of the American Chemical Society, 1999, 121, 2965-2973. 22. Ogilvie, W. W.; Yoakim, C.; D�, F.; Hach�, B.; Lagac�, L.; Naud, J.; O�Meara, J.A.; D�ziel, R. �Synthesis and Antiviral Activity of Monobactams Inhibiting the Human Cytomegalovirus Protease� Bioorganic & Medicinal Chemistry, 1999, 7, 1521-1531. 21. Nicolaou, K.C.; Shi, G.-O.; Gunzer, J.L.; Gartner, P.; Wallace, P.A.; Ouellette, M.A.; Shi, S.; Bunnage, M.E.; Agrios, K.; Veale, C.A.; Hwang, C.-K.; Hutchinson, J.; Prasad, C.V.C.; Ogilvie, W.W.; Yang, Z. �Total Synthesis of Brevetoxin A: Part 3: Construction of GHIJ and BCDE ring systems.� Chem. Eur. J. 1998, 5, 628-645. 20. Simoneau, B.; Lavall�e, P.; Anderson, P.C.; Bailey, M.; Bantle, G.; Berthiaume, S.; Chabot, C.; Fazal, G.; Halmos, T.; Ogilvie, W.W.; Poupart, M.-A.; Thavonekham, B.; Xin, Z.; Thibeault, D.; Bolger, G.; Panzenbeck, M.; Winquist, R.; Jung, G.L. �Discovery of Non-Peptidic P2-P3 Butanediamide Renin Inhibitors with High Oral Efficacy� Bioorganic & Medicinal Chemistry, 1998, 7, 489-508.