个人简介
教育背景
2007-09--2012-07 北京大学 理学博士
2003-09--2007-07 山东大学 理学学士
工作简历
2019-03~现在, 国家纳米科学中心, 特聘研究员
2018-06~2019-06,美国布兰迪斯大学, 访问学者
2016-03~2019-03,国家纳米科学中心, 副研究员
2012-07~2016-03,国家纳米科学中心, 助理研究员
2007-09~2012-07,北京大学, 理学博士
2003-09~2007-07,山东大学, 理学学士
科研项目
( 1 ) 温敏型聚合物-多肽连接体的体内自组装行为及抗癌性能研究, 主持, 国家级, 2017-01--2020-12
( 2 ) 新型功能性多肽聚合物的制备及其抗癌性能研究, 主持, 国家级, 2013-01--2016-12
( 3 ) 可形变多肽纳米材料在体原位构建抗癌药物库及其生物学效应研究, 主持, 国家级, 2019-01--2022-12
近期论文
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Near-Infrared Laser-Triggered In Situ Dimorphic Transformation of BF2-Azadipyrromethene Nanoaggregates for Enhanced Solid Tumor Penetration, ACS Nano, 2020, 通讯作者
Ultrasound-Activated Cascade Effect for Synergistic Orthotopic Pancreatic Cancer Therapy, iScience, 2020, 通讯作者
Photothermal-Promoted Morphology Transformation in Vivo Monitored by Photoacoustic Imaging, Nano Lett., 2020, 通讯作者
Cell-Penetrating peptides and polymers for improved drug delivery, ChemNanoMat, 2020, 通讯作者
Autocatalytic Morphology Transformation Platform for Targeted Drug Accumulation, J. Am. Chem. Soc., 2019, 通讯作者
Endogenous Reactive Oxygen Species-Triggered Morphology Transformation for Enhanced Cooperative Interaction with Mitochondria, J. Am. Chem. Soc., 2019, 通讯作者
Site-Specific Construction of Long-Term Drug Depot for Suppression of Tumor Recurrence, Small, 2019, 通讯作者
Microenvironment-Induced In Situ Self-Assembly of Polymer-Peptide Conjugates That Attack Solid Tumors Deeply, Angew. Chem. Int. Ed., 2019, 通讯作者
Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics, Advanced materials, 2019, 通讯作者
Near-Infrared Laser-Driven in Situ Self-Assembly as a General Strategy for Deep Tumor Therapy, Nano Lett., 2018, 通讯作者
Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration, Biomater. Sci., 2018, 通讯作者
High-Performance Identification of Human Bladder Cancer Using a Signal Self-Amplifiable Photoacoustic Nanoprobe, ACS Appl. Mater. Interfaces, 2018, 通讯作者
An "On-Site Transformation" Strategy for Treatment of Bacterial Infection, Advanced materials, 2017, 通讯作者
Reconfigurable Peptide Nanotherapeutics at Tumor Microenvironmental pH, ACS Appl. Mater. Interfaces, 2017, 第 1 作者
Polymer-KLAK Peptide Conjugates Induce Cancer Cell Death through Synergistic Effects of Mitochondria Damage and Autophagy Blockage, Bioconjugate Chem., 2017, 第 1 作者
In Situ Monitoring Intracellular Structural Change of Nanovehicles through Photoacoustic Signals Based on Phenylboronate-Linked RGD-Dextran/Purpurin 18 Conjugates, Biomacromolecules, 2017, 通讯作者
One-pot synthesis of pH-responsive hyperbranched polymer-peptide conjugates with enhanced stability and loading efficiency for combined cancer therapy, Polym. Chem., 2017, 通讯作者
A General Strategy for Facile Synthesis and in Situ Screening of Self-Assembled Polymer-Peptide Nanomaterials, Adv. Mater., 2016, 第 1 作者
Self-Assembled ROS-Sensitive Polymer–Peptide Therapeutics Incorporating Built-in Reporters for Evaluation of Treatment Efficacy, Biomacromolecules, 2016, 第 1 作者
Self-assembly of Cytotoxic Peptide Conjugated Poly(β-amino ester)s for Synergistic Cancer Chemotherapy, J. Mater. Chem. B, 2015, 第 1 作者