Gillingham, Dennis - University of Basel

研究领域

We use the techniques of physical organic chemistry, synthetic chemistry, catalysis, and chemical biology to answer questions about Nature. We are particularly interested in the chemistry and biology of nucleic acids.

近期论文

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Yu Wang, Kiran Patil, Shuanghong Yan, Weiming Guo, Yuqin Wang, Panke Zhang, Hong-Yuan Chen, Dennis G. Gillingham and Shuo Huang, «Nanopore sequencing accurately identifies the mutagenic DNA lesion O6‐carboxymethyl guanine and reveals its behavior in replication», Angew. Chem. Int. Ed. 2019, ASAP. doi:10.1002/anie.201902521. Cedric J. Stress, Basilius Sauter, Lukas Schneider, Timothy Sharpe and Dennis G. Gillingham, «A DNA‐encoded chemical library incorporating elements of natural macrocycles», Angew. Chem. Int. Ed. 2019, ASAP. doi:10.1002/anie.201902513. This article was published first as a draft in ChemRXiv: Cedric J. Stress, Basilius Sauter, Lukas Schneider, Timothy Sharpe and Dennis G. Gillingham, «A DNA-Encoded Macrocycle Library that Resembles Natural Macrocycles», ChemRxiv 2019. doi:10.26434/chemrxiv.7679984 Seemon Coomar and Dennis G. Gillingham, «Exploring DCAF15 for reprogrammable targeted protein degradation», bioRxiv 2019, 542506, preprint. doi:10.1101/542506. Michael H. Räz, Emma Sandell, Kiran Patil, Dennis G. Gillingham and Shana J. Sturla, «High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O⁶-carboxymethylguanine Structures», ACS Chem. Biol. 2019. doi:10.1021/acschembio.8b00802. Stefanie Geigle, Dnyaneshwar Rasale and Dennis G. Gillingham, «Synthesis of Various Water Soluble and Stable Copper Complexes Bearing N‐Heterocyclic Carbene Ligands and Their Activity in DNA Alkylation», Helvetica Chimica Acta 2019, 102, e1800183. doi:10.1002/hlca.201800183. Dennis G. Gillingham and Dnyaneshwar Rasale, «Direct and Selective Modification of RNA – An Open Challenge in Nucleic Acid Chemistry», Chimia 2018, 72, 11, 777─781. doi:10.2533/chimia.2018.777. Dnyaneshwar Rasale, Kiran Patil, Basilius Sauter, Stefanie Geigle, Saule Zhanybekova and Dennis G. Gillingham, «A new water soluble copper N-heterocyclic carbene complex delivers mild O6G-selective RNA alkylation», Chemical Communications 2018, 54, 9174─9177. doi:10.1039/C8CC04476G. Basilius Sauter and Dennis G. Gillingham, «Profiling the nucleobase and structure selectivity of anticancer drugs and other DNA alkylating agents by RNA sequencing », ChemBioChem 2018, 19, 1638─1642. doi:10.1002/cbic.201800235. Jingming Zhao, Daniel Bachmann, Markus Lenz, Dennis G. Gillingham and Thomas R. Ward, «An Artificial Metalloenzyme for Carbene Transfer Based on a Biotinylated Dirhodium Anchored within Streptavidin», Catalysis Science & Technology 2018, 8, 2294─2298. doi:10.1039/C8CY00646F. Dennis G. Gillingham and Basilius Sauter, «Genomic studies reveal new aspects of the biology of DNA damaging agents», ChemBioChem 2017, 18, 2368─2375. doi:10.1002/cbic.201700520. Stefanie Geigle, Laura A. Wyss, Shana J. Sturla and Dennis G. Gillingham, «Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction», Chemical Science 2017, 8, 499─506. doi:10.1039/c6sc03502g. Dennis G. Gillingham, «The role of boronic acids in accelerating condensation reactions of α-effect amines with carbonyls», Organic & Biomolecular Chemistry 2016, 14, 7606─7609. doi:10.1039/C6OB01193D. Na Fei, Basilius Sauter and Dennis G. Gillingham, «The pKa of Bronsted acids controls their reactivity with diazo compounds.», Chemical Communications 2016, 52, 47, 7501─7504. doi:10.1039/c6cc03561b. Cedric J. Stress, Pascal Schmidt and Dennis G. Gillingham, «Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant.», Organic & Biomolecular Chemistry 2016, 14, 24, 5529─5533. doi:10.1039/C6OB00168H. Dennis G. Gillingham, Stefanie Geigle and O. Anatole Lilienfeld, «Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics», Chemical Society Reviews 2016, 45, 9, 2637─2655. doi:10.1039/c5cs00271k. Kiril Tishinov and Dennis G. Gillingham, «Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB», Synlett 2015, 26, 19, 2720─2723. doi:10.1055/s-0035-1560491. Daniel Bachmann, Pascal Schmidt, Stefanie Geigle, Antoinette Chougnet, Wolf-Dietrich Woggon and Dennis G. Gillingham, «Modular Ligands for Dirhodium Complexes Facilitate Catalyst Customization», Advanced Synthesis & Catalysis 2015, 357, 9, 2033─2038. doi:10.1002/adsc.201500050. Dennis G. Gillingham and Ramla Shahid, «Catalysts for RNA and DNA modification», Current Opinion in Chemical Biology 2015, 25, 110─114. doi:10.1016/j.cbpa.2014.12.025. Pascal Schmidt, Cedric J. Stress and Dennis G. Gillingham, «Boronic acids facilitate rapid oxime condensations at neutral pH», Chemical Science 2015, 6, 6, 3329─3333. doi:10.1039/C5SC00921A.