个人简介

Research conducted in the Keillor Lab can be divided into two areas. The first touches on several aspects of enzymology – studying the detailed mechanisms by which enzymes function, synthesizing and testing inhibitors with therapeutic potential, and engineering enzymes for practical catalytic applications. The second area involves the development of methods for labelling specific proteins in living cells, for the subsequent study of their structure, localisation and trafficking. The methodology used in the Keillor Lab for both of these two lines of research comprises several different disciplines, including organic synthesis, molecular biology and the spectroscopy implicated in detailed kinetic studies.

研究领域

Research conducted in the Keillor Lab can be divided into two areas. The first touches on several aspects of enzymology – studying the detailed mechanisms by which enzymes function, synthesizing and testing inhibitors with therapeutic potential, and engineering enzymes for practical catalytic applications. The second area involves the development of methods for labelling specific proteins in living cells, for the subsequent study of their structure, localisation and trafficking. The methodology used in the Keillor Lab for both of these two lines of research comprises several different disciplines, including organic synthesis, molecular biology and the spectroscopy implicated in detailed kinetic studies.

Prof. Keillor’s research interests lie at the interface of chemistry, biochemistry and biology. In a distinctively multidisciplinary approach, all group members have the opportunity to receive training in organic synthesis, molecular biology, spectroscopy and kinetic studies, valuable skills for the fields of biopharmaceuticals, biotechnology and biocatalysis. Two general research themes are prevalent in the Keillor group: the study of the function, inhibition and engineering of enzymes, and the development of novel methods for the site-specific labelling of proteins. The projects described below are representative of our current research efforts in some of the research areas of modern bioorganic chemistry.

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Chabot, N., Moreau, S., Mulani, A., Moreau, P., Keillor, J.W. Fluorescent probes of tissue transglutaminase reveal its association with arterial stiffening. Chem. & Biol., 17, 1143-1150, 2010 Guy, J., Castonguay, R., Campos-Reales Piñeda, N.B., Jacquier, V., Caron, K., Michnick, S.W., Keillor, J.W. De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy. Mol. BioSys., 6, 976-987, 2010 Pardin, C., Chica, R.A., Roy, I., Bonneil, E., Thibault, P., Lubell, W., Pelletier, J.N., Keillor, J.W. Photolabeling of tissue transglutaminase reveals binding mode of potent cinnamoyl inhibitors. Biochemistry, 48, 3346-3353, 2009 Pardin, C., Pelletier, J.N., Lubell, W.D., Keillor, J.W. Cinnamoyl inhibitors of tissue transglutaminase. J. Org. Chem., 73, 5766-5775, 2008 Keillor, J.W., Chica, R.A., Chabot, N., Vinci, V., Pardin, C., Fortin, E., Gillet, S.M.F.G., Nakano, Y., Kaartinen, M.T., Pelletier, J.N., Lubell, W.D. The bioorganic chemistry of transglutaminase: From mechanism to inhibition and engineering. Can. J. Chem., 86, 271-176, 2008