Walsh, Heidi - Wabash College - Department of Biology

个人简介

Postdoctoral Fellowship, The Scripps Research Institute, Department of Metabolism & Aging Ph.D. in Neuroscience, University of Virginia B.S. in Neuroscience, Allegheny College

研究领域

My research focuses on understanding how obesity affects a part of the brain called the hypothalamus – the brain’s central regulator of food intake, metabolism, hormone release, and reproduction. Excess circulating nutrients in obese individuals cause dysfunction of the hypothalamic neurons that control food intake by interfering with normal protein folding in the endoplasmic reticulum (ER). When the protein folding load exceeds cellular capacity, an ER stress response is initiated by the cell via a defined set of signal transduction pathways. In hypothalamic food intake neurons, ER stress interferes with the ability of these cells to respond appropriately to hormonal signals and control appetite.

近期论文

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Kern A, Albarran-Zeckler R, Walsh HE, Smith RG. 2012. Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron, 73(2):317-32. Walsh HE, Shupnik MA. 2009. Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter. Molecular Endocrinology, 23(2):237-50. Haisenleder DJ, Burger LL, Walsh HE, Stevens J, Aylor KW, Shupnik MA, Marshall JC. 2008. Pulsatile GnRH Stimulation of Gonadotropin Subunit Transcription in Rat Pituitaries: Evidence for the Involvement of Jun N-Terminal Kinase (JNK) but not p38. Endocrinology, 149(1):139-45. Ferris HF, Walsh HE, Stevens J, Fallest PC, Shupnik MA. 2007. Luteinizing Hormone Beta Promoter Stimulation by cyclic AMP and Cooperation with GNRH1 in Transgenic Mice and LBetaT2 Cells. Biology of Reproduction, 77(6):1073-80. Kowase T, Walsh HE, Darling DS, Shupnik MA. 2007. Estrogen Enhances GnRH-Stimulated Transcription of the LH Subunit Promoters via Altered Expression of Stimulatory and Suppressive Transcription Factors. Endocrinology, 148(12):6083-91.