Goonesekere, Nalin - University of Northern Iowa - Department of Chemistry and Biochemistry

个人简介

Degrees B.Sc. University of Colombo, Sri Lanka. Ph.D. Princeton University. Research Fellow - National Cancer Institute, Bethesda

研究领域

The dawn of the 21st century can be characterized as the golden era in biochemistry, as much as the dawn of the 20th century was the golden era for physics. In 2003, we witnessed the complete sequencing of human DNA (genome) and we now have access to many mammalian, plant and microbial genomes. An important scientific challenge for the 21st century is interpreting the vast amounts of DNA sequence data that has become available. Understanding the DNA sequence information is critical in converting this information into tangible benefits to humankind - whether it be new protein targets for drugs, or perhaps more efficient enzymes for use in biotechnology. Research conducted in our laboratory focuses on the broad problem of interpreting DNA sequence data to obtain biologically meaningful information

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Schutt, C.E., Myslik, J.C., Rozycki, M.D., Goonesekere, N.C.W. and Lindberg, U. (1993) The Structure of profilin:actin at 2.55 angstrom resolution Nature 365 810. Zeppezauer, E. S. C., Goonesekere, N.C.W., Rozycki, M.D., Myslik, J.C., Dauter, Z., Lindberg, U. and Schutt, C.E. (1994) The structure of profilin at 2.0 angstrom resolution J Mol Biol 240 459. Goonesekere, N.C.W., Gunasekera, M.B. and Fernandopulle, N. (1999) Use of DNA typing For Criminal Casework in Sri Lanka. Proceedings of the 10th International Symposium on Human Identification Promega Corporation,Wisconsin, U.S.A. Tiedemann, R., Kurt, F., Goonesekere, N.C.W., Gunasekera, M.B., and Ratnasooriya, W.D. (1999) A simulation study on the viability of Sri Lankan elephant populations. Folia Zoologica 48 (supp. 1): 95-104. Fernandopulle, N., Gunasekera, M.B. and Goonesekere, N.C.W. (2002) Population genetics of eight STR loci from Sri Lanka. Forensic Science International 126 1 93. Vandebona, H., Goonesekere, N.C.W., Ratnasooriya, W.D., Alahakoon, J. and Gunasekera, M.B. (2002) The establishment of paternity of elephants born in captivity in Pinnawela Elephant Orphanage, Sri Lanka, by DNA fingerprinting. International Zoo Yearbook 39. Vandebona, H., Goonesekere, N.C.W., Tiedemann, R., Ratnasooriya, W.D., and Gunasekera, M.B. (2002) Sequence variation at two mitochondrial genes in the Asian elephant (Elephas maximus) population in Sri Lanka. Mam Biol 67 4 193. Mapatuna, Y., Gunasekera, M.B., Ratnasooriya W.D., Goonesekere, N.C.W. & Bates P.J.J. (2002) Unravelling the taxonomic status of the Genus Cynopterus (Chiroptera:Pteropodidae) in Sri Lanka by multivariate morphometrics and mitochondrial DNA sequence analysis Mam Biol67: 321. Goonesekere, N.C.W. and Lee B. (2004) Frequency of gaps observed in a structurally aligned protein pair database suggest a simple gap penalty function Nucleic Acids Research 32 9 2838.