李任植 - 南开大学 - 物理科学学院

个人简介

教育经历理学博士，（生）物理，英国布里斯托尔（Bristol）大学H.H.Wills物理研究所1989. 9 – 1993. 1 学士，物理学，釜山大学1982. 3 – 1986. 2 工作经历 2003. 4 - 现任南开大学 2002. 8 – 2003.3 日本东京医科齿科大学 1998. 7 – 2002. 7 美国Case Western Reserve大学，医工学 1997.7– 1998. 6 香港大学 1995. 7 –1997. 6 中国科学院，化学研究所 1992. 12 –1995. 7 延边科技大学 1991. 10 –1992. 9 英国布里斯托尔(Bristol)大学H.H.Wills物理研究所教学工作 Molecular Biophysics (Undergraduate) Nanobiophysics(Graduate) Theoretical Biophysics (Graduate) Biophysics (Undergraduate) 荣誉奖励 Travel Awards for an outstanding young scientists (2001, Congress ofBiomaterials) Outstanding Paper at 11th annual assembly of Chinese Weed Society,Changsha, China(2013)

研究领域

Nanobiointerfaces: 1. Bio-interfaces: Nanotechniques make a possible to study single molecular kinetics at the nanobiointerface including ligand-receptor interactions. Applying dynamic measurement of the interaction, energy landscape could be understood at the ligand-receptor binding. (Example: Single molecular GPIIb3a-RGD ligand interaction, Surf. Sci 2001, 491: 433-443) 2. Chemo-interfaces: Biomimetic and bio-pattern studies: designing Biomimetic molecules and characterizing their interfacial properties at the single molecular level. The cellular nano-interfaces were also applied in controlling cell growth patterns.(Example: Biomimetic nanohydrogel, Biomaterials, 2004, 25, 1911-1918). This work included the computer modeling and molecular designs (ex. Herbicides and cyclic antagonistic peptides). 3. Physio-interfaces: The conventional stimuli were considered only in biochemical stimulus. My research investigates the physical stimuli such as mechanical, optical (electromagnetic) and thermal stimuli at the cells. How the cells responding against physical stimuli is studying with combination of optical and biophysical techniques. Another crucial question is how the physical stimuli were converted into the physiological signals. From conventional static physical stimuli to dynamic stimuli is on characterizing. Those results will build a new paradigm in controlling biological functions with physical stimulus.

近期论文

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Xuehe Ma, Haimei Zhang, Shiyu Deng, Qiushuo Sun, Qingsong Hu, Yuhang Pan, Fen Hu, Imshik Lee, Fulin Xing, and Leiting Pan (2024) Single-cell manipulation by two-dimensional micropatterning. Journal of Innovative Optical Health SciencesVol. 17, No. 01, 2330011 (2024). https://doi.org/10.1142/S1793545823300112 Yipeng Cao, Rui Yang, Wei Wang, Shengpeng Jiang, Chengwen Yang, Qingxin Wang, Ningbo Liu, Yi Xue, Imshik Lee, Xiangfei Meng, Zhiyong Yuan (2023) Effects of membrane lipids on phospholamban pentameric channel structure and ion transportation mechanisms, International Journal of Biological Macromolecules 224:766-775 https://doi.org/10.1016/j.ijbiomac.2022.10.164 . Fulin Xing, Haimei Zhang, Mengyu Li, Hao Dong, Xuehe Ma, Shiyu Deng, Fen Hu, Imshik Lee, Leiting Pan, Jingjun Xu (2022) Regulation of actin cytoskeleton via photolithographic micropatterning. Journal of Innovative Optical Health Sciences https://doi.org/10.1142/S1793545822440059 Guixian Meng, Fang Fang, Lusheng Guo, Wei Liu, Imshik Lee*, Chen Zhao* (2022) Calcium Response of Spatially Arranged Cell Networks to Shear Stress by Confined Single Cell Patterned Microfluidic Chips. BBRC, 611:140-145. http://doi.org/10.1016/j.bbrc.2022.04.049 Yipeng Cao, Rui Yang, Wei Wang, Shengpeng Jiang, Chengwen Yang, Ningbo Liu, Hongji Dai, Imshik Lee, Xiangfei Meng, Zhiyong Yuan (2022) Probing the Formation, Structure and Free Energy Relationships of M Protein Dimers of SARS-CoV-2. Computational and Structural Biotechnology Journal, 20:573-582. https://doi.org/10.1016/j.csbj.2022.01.007 Yipeng Cao, Rui Yang, Imshik Lee, Wenwen Zhang, Jiana Sun, Wei Wang Xiangfei Meng (2021) Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin and Inhibitors. Protein Science,30(6):1114-1130.https://doi.org/10.1002/pro.4075 Yipeng Cao, Rui Yang, Imshik Lee, Wenwen Zhang, Jiana Sun, Wei Wang (2021) Prediction of LncRNA Encoded Small Peptides in Glioma and The Oligomer Channel Functional Analysis Using in Silico Approaches, PLoS ONE 16(3):e0248634, https://doi.org/10.1371/journal.pone.0248634 Fen Hu, Donglan Zhu, Weiwei Pei, Imshik Lee, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Rhein inhibits ATP-triggered inflammatory responses in rheumatoid rat fibroblast-like synoviocytes. International Immunopharmacology, 2019, 75: 105780 (IF:5.6) Fen Hu, Yali Zhao, Zhenhai Hui, Fulin Xing, Jianyu Yang, Imshik Lee, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Regulation of intracellular Ca2+/CaMKII signaling by TRPV4 membrane translocation during osteoblastic differentiation. Biophysics Reports, 2019, 5(5): 254-263