个人简介

The Boddy lab focuses on harnessing biosynthetic pathways to produce complex molecules. Using synthetic chemistry and biochemistry, we try to determine how microorganisms construct complex biologically active molecules. We then try to take advantage of these biosynthetic pathways to produce complex natural products and their analogs. This provides us with the necessary compounds to develop enzyme inhibitors, study mechanisms of action, or determine structure-activity relationships.

研究领域

Organic and Biological Chemistry Natural products Polyketides Nonulosinic acids Biosynthetic pathways Synthetic chemistry Biomimetic total synthesis Biochemistry Enzymology Molecular microbiology Metabolic engineering

The research interests of my laboratory lie at the interface of chemistry and biology. Using synthetic chemistry, biochemistry, and molecular biology, we try to determine how microorganisms build complex biologically active molecules. With this knowledge we then try to harness these biosynthetic pathways to produce complex natural products and their analogs. This provides us with biorenewable access to commodity and fine chemicals as well as access to chemical diversity for biomedical applications including drug discovery and molecular pharmacology.

近期论文

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Natural products: Mapping an amazing thicket. Mark E. Horsman, Christopher N. Boddy Nature Chem. Biol. 2016, 13, 6-7. DOI: 10.1038/nchembio.2265. Portable, On-Demand Biomolecular Manufacturing. Keith Pardee, Shimyn Slomovic, Peter Q. Nguyen, Jeong Wook Lee, Nina Donghia, Devin Burrill, Tom Ferrante, Fern R. McSorley, Yoshikazu Furuta, Andyna Vernet, Michael Lewandowski, Christopher N. Boddy, Neel S. Joshi, James J. Collins, Cell 2016, 167, 248-259. DOI: 10.1016/j.cell.2016.09.013 Inducible T7 RNA polymerase-mediated multigene expression system, pMGX. Hassan, M. I; McSorley, F. R.; Hotta, K.; Boddy, C. N. J. Vis. Exp. 2016. In press. Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analog. Hassan, M. I.; Lundgren, B. L.; Chaumun, M.; Whitfield, D. M.; Clark, B.; Schoenhofen, I. C.; Boddy, C. N. Angew. Chem. Int. Ed. 2016, 55, 12018-12021. DOI: 10.1002/anie.201606006 First-in-class small molecule potentiators of cancer virotherapy. Dornan, M. H.; Krishnan, R.; Macklin, A. M.; Selman, M.; El Sayes, N.; Son, H. H.; Davis, C.; Chen, A.; Keillor, K.; Le, P. J.; Moi, C.; Ou, P.; Pardin, C.; Canez, C. R.; Le Boeuf, F.; Bell, J. C.; Smith, J. C.; Diallo J.-S.; Boddy C. N. Sci. Rep. 2016, 6, 26786. DOI: 10.1038/srep26786 N-Acetylneuraminic acid production in Escherichia coli lacking N-acetylglucosamine catabolic machinery. Horsman, M. E.; Lundgren, B. L.; Boddy, C. N. Chem. Eng. Commun. 2016, 203. 1326-1335. DOI: 10.1080/00986445.2016.1188293 The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways. Tremblay, N.; Hill, P.; Conway, K.; R; Boddy, C. N. Meth. Mol. Biol. 2016, 233-252. ISBN: 978-1-4939-3375-4 Diastereoselective Transannular Oxa-conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide. Hari, T. P.; Wilke, B. I.; Davey, J.; Boddy, C. N. J. Org. Chem. 2015, 81(2), 415-423. DOI: 10.1021/acs.joc.5b02014 Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. Argyropoulos, P.; Bergeret, F.; Pardin, P.; Reimer J. M.; Pinto, A.; Boddy, C. N.; Schmeing, M. BBA - General Subjects 2015, 1860, 486-497. DOI: 10.1016/j.bbagen.2015.11.007 Draft Genome Sequence of Streptomyces sp. Strain PBH53, isolated from urban environment. Gosse, J. T.; Hill, P.; Dowd, S. E.; Boddy, C. N. Genome Announc. 2015, 3, e00859-15, DOI: 10.1128/genomeA.00859-15. Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy. Simoncelli, S.; de Alwis Weerasekera, H.; Fasciani, C.; Boddy, C. N.; Aramendía, P.; Alarcon, E.; Scaiano, J. J. Phys. Chem. Lett. 2015, 6 1499-1503, DOI: 10.1021/acs.jpclett.5b00272. Polyketide Synthase and Non-Ribosomal Peptide Synthetase Thioesterase Selectivity: Logic Gate or a Victim of Fate? Horsman, M. E.; Hari, T. P. A; Boddy, C. N. Nat. Prod. Rep. 2015. DOI: 10.1039/c4np00148f. Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation. Capicciotti, C. J.; Poisson, J. S.; Boddy, C. N.; Ben, R. N. Cryobiology 2015, DOI: 10.1016/j.cryobiol.2015.01.002. Resorcylic acid lactone biosynthesis relies on a stereo-tolerant macrocyclizing thioesterase. Heberlig, Graham; Wirz, Monica; Wang, Meng; Boddy, Christopher N. Org. Lett. 2014, 16, 5858-5861. Salvadenosine, a 5'-Deoxy-5'-methylthio Nucleoside from the Bahamian Tunicate, Didemnum sp. Jamison, M. T.; Boddy, C. N.; Molinski, T. F. J. Org. Chem. 2014, 79, 9992–9997. An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases. Hari, Taylor P.A.; Labana, Puneet; Boileau, Meaghan; Boddy, Christopher N., ChemBioChem 2014, 15, 2656-61. DOI: 10.1002/cbic.201402475. Genetic Analysis of the Assimilation of C-5-Dicarboxylic Acids in Pseudomonas aeruginosa PAO1. Lundgren, B.R.; Villegas-Peñaranda, L. R.; Harris, J. R.; Mottern, A. M.; Dunn, D. M.; Boddy, C. N.; Nomura, C. T. Journal of Bacteriology 2014, Volume 196, Issue 14, Pages 2543-2551. DOI: 10.1128/JB.01615-14 Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. Boddy C.N. Journal of Industrial Microbiology & Biotechnology 2014, Volume 41, Issue 2 Special Issue SI, Pages 443-450. DOI: 10.1007/s10295-013-1368-1. Hexanes/acetonitrile: A binary solvent system for the efficient monosilylation of symmetric primary and secondary diols. Wilke, Burkhardt I.; Dornan, Mark H.; Yeung, Jon; Boddy, Christopher N.; Pinto, Atahualpa. Tetrahedron Lett. 2014, 55, 2600–2602. DOI: 10.1016/j.tetlet.2014.02.067