个人简介

The Ben Lab research interests may be divided into primarily two areas. These are asymmetric synthesis of compounds possessing unusual biological or medicinal properties (methodology development) and bioorganic chemistry (rational design and synthesis of low molecular weight biological antifreezes with enhanced stability and activity for medical, commercial and industrial applications).

研究领域

Organic and Biological Chemistry Synthetic, organic and bio-organic chemistry Symmetric synthesis Asymmetric synthesis Glycoprotein Carbohydrate chemistry Peptide chemistry

The Ben Lab research interests may be divided into primarily two areas. These are asymmetric synthesis of compounds possessing unusual biological or medicinal properties (methodology development) and bioorganic chemistry (rational design and synthesis of low molecular weight biological antifreezes with enhanced stability and activity for medical, commercial and industrial applications).

近期论文

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Poisson, J. S.; Briard, J. G.; Turner, T. R.; Acker, J. P.; Ben, R. N. Hydroxyethyl Starch Supplemented with Ice Recrystallization Inhibitors Greatly Improves Cryopreservation. BioProcessing Journal 2017, 15(4). Adam, M. K.; Hu, Y.; Poisson, J. S.; Pottage, M. J.; Ben, R. N. Wilkinson, B. L. Photoswitchable Carbohydrate-Based Fluorosurfactants as Tuneable Ice Recrystallization Inhibitors. Carbohydr. Res. 2017, 439, 1. Briard, J. G.; Jahan, S.; Chandran, P.; Allan, D.; Pineault, N.; Ben, R. N. Small-Molecule Ice Recrystallization Inhibitors Improve the Post-Thaw Function of Hematopoietic Stem and Progenitor Cells. ACS Omega 2016, 1(5), 1010. Capicciotti, C. J.; Mancini, R. S.; Turner, T. R.; Koyama, T.; Alteen, M. G.; Doshi, M.; Inada, T.; Acker, J. P.; Ben, R. N. O-Aryl- Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure-Function Study. ACS Omega 2016, 1(4), 656. Briard, J. G.; Fernandez, M.; De Luna, P.; Woo, T. K.; Ben, R. N. QSAR Accelerated Discovery of Potent Ice Recrystallization Inhibitors. Nature Sci. Reports 2016, 6, 26403. Adam, M. K.; Poisson, J. S.; Hu, Y.; Prasannakumar, G.; Pottage, M. J.; Ben, R. N.; Wilkinson, B. L. Carbohydrate-Based Surfactants as Photocontrollable Inhibitors of Ice Recrystallization. RSC Advances 2016, 6, 39240. Briard, J. G.; Poisson, J. S.; Turner, T. R.; Capicciotti, C. J.; Acker, J. P.; Ben, R. N. Small Molecule Ice Recrystallization Inhibitors Mitigate Red Blood Cell Lysis During Freezing, Transient Warming and Thawing. Nature Sci. Reports 2016, 6, 23619. Chow-Shi-Yee, M.; Briard, J. G.; Grondin, M.; Averill-Bates, D. A.; Ben, R. N.; Ouellet, F. Inhibition of Ice Recrystallization and Cryoprotective Activity of Wheat Proteins in Liver and Pancreatic Cells. Protein Sci. 2016, 25, 974. Capicciotti, C. J.; Kurach, J. D. R.; Turner, T. R.; Mancini, R. S.; Acker, J. P.; Ben, R. N. Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations. Nature Sci. Reports 2015, 5, 9692. Tonelli, D.; Capicciotti, C. J.; Doshi, M.; Ben, R. N. Inhibiting Gas Hydrate Formation Using Small Molecule Ice Recrystallization Inhibitors. RSC Advances 2015, 5, 21728. Capicciotti, C. J.; Poisson, J.; Boddy, C. N.; Ben, R. N. Modulation of Antifreeze Activity and the Effect Upon Post-thaw HepG2 Cell Viability after Cryopreservation. Cryobiology 2015, 70, 79. Briard, J. G.; Ben, R. N. Synthesis of N-(4-methoxybenzyl)-2(alpha-Dglycopyranosyl)acetamide. Proven Methods in Carbohydrate Chemistry, 2015, 3, in press. Balcerzak, A. K.; Capicciotti, C. J.; Briard, J. G.; Ben, R. N. Designing Ice Recrystallization Inhibitors: from Antifreeze (Glyco)proteins to Small Molecules. RSC Advances 2014, 4, 42682. Ghobadloo, S. M.; Balcerzak, A. K.; Gargaun, A.; Mironov, G. R.; Capicciotti, C. J.; Briard, J. G.; Ben, R. N.; Berezovski, M. V.. Carbohydrate-based Ice Recrystallization Inhibitors Increase Infectivity and Thermostability of Viral Vectors. Nature Sci. Reports 2014, 4, 5903. van der Wal, S.; Capicciotti, C. J.; Rontogianni, S.; Ben, R. N.; Liskamp, R. M. J. Synthesis and Evaluation of Linear CuAAC-oligomerized antifreeze neo-glycopeptides. MedChemComm 2014, 5, 1159. Capicciotti, C. J.; Doshi, M.; Ben, R.N. (2013). Ice Recrystallization Inhibitors: From Biological Antifreezes to Small Molecules (P. Wilson, Ed.). In Recent Developments in the Study of Recrystallization (pp. 177-224). New York, NY: InTech. Corcilius, L.; Santhakumar, G.; Stone, R. S.; Capicciotti, C. J.; Joseph, S.; Matthews, J. M.; Ben, R. N.; Payne, R. J. Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules. Bioorganic and Medicinal Chemistry 2013, 21, 3569. Balcerzak, A. K.; Febbraro, M.; Ben, R. N. The Importance of Hydrophobic Moieties in Ice Recrystallization Inhibitors. RSC Advances 2013, 3, 3232. Capicciotti, C.; Leclere, M.; Perras, F.; Bryce, D.L.; Paulin, H.; Harden, J.; Ben, R.N. Potent Inhibition of Ice Recrystallization by Low Molecular Weight Carbohydrate-based Surfactants and Hydrogelators. Chemical Science 2012, 3, 1408. Wilkinson, B. L.; Stone, R. S.; Capicciotti, C. J.; Thaysen-Andersen, M.; Matthews, J. M.; Packer, N. H.; Ben, R. N.; Payne, R. J. Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins. Angew. Chem. Int. Ed. Eng. 2012, 51, 3606. Wu, L.K.; Al-Hejazi, A.; Filion, L.; Ben, R.N.; Halpenny, M.; Yang, L.; Giulivi, A.; Allan, D.S. Increased Apoptosis in Cryopreserved Autologous Hematopioetic Progenitor Cells Collected by Apheresis and Delayed Neutrophil Recovery after Transplanation: A Nested Case-controlled Study. Cytotherapy 2012, 14, 205. Balcerzack, A.; Ferreirra, S.S.; Trant, J.F.; Ben, R.N. Structurally Diverse Disaccharide Analogues of Antifreeze Glycoproteins and their Ability to Inhibit Ice Recrystallization. Bioorganic and Medicinal Chemistry Letters 2012, 22, 1719. Chaytor, J.L.; Tokarew, J.M.; Wu, L.K.; Leclere, M.; Tam, R.Y.; Capicciotti, C.J.; Guolla, L.; von Moos, E.; Findlay, C.S.; Allan, D.S.; Ben, R.N. Inhibiting Ice Recrystallization and Optimization of Cell Viability after Cryopreservation. Glycobiology 2012, 22, 123. Leclere, M.; Kwok, B.; Wu, L.K.; Allan, D.S.; Ben, R.N. C-Linked AFGP Analogues as Novel Cryoprotectants. Bioconjugate Chemistry 2011, 22, 1804. Capicciotti,C.; Trant, J.F.; Leclere, M.; Ben, R.N. Synthesis of C-Linked Triazole-Containing AFGP Analogues and Their Ability to Inhibit Ice Recrystallization. Bioconjugate Chemistry 2011, 22, 605.