赵强 - 南开大学 - 生命科学学院

个人简介

南开大学生命科学学院教授（博士生导师），生物活性材料教育部重点实验室副主任和天津市生物活性材料重点实验室主任。获得国家优秀青年科学基金和天津市杰出青年科学基金资助，入选天津市131人才第一层次和南开大学“百名青年学科带头人”计划。担任中国解剖学会血管分会常委、中国生理学会基质生物学分会委员（青委会副主委）、中国生物医学工程学会组织工程与再生医学分会委员（青委会副主委）等。教育经历 2004/3 - 2006/9，天津大学，材料学，博士 2001/9 - 2004/2，天津大学，材料学，硕士 1997/9 - 2001/7，西北工业大学，高分子材料与工程，学士工作经历 2014/12 - 至今，南开大学，生命科学学院，教授 2009/11 – 2014/12，南开大学，生命科学学院，副教授 2014/3 - 2014/4，英国伦敦大学国王学院，医学院，访问学者 2006/9 - 2009/9，香港城市大学，物理与材料科学系，博士后研究员

研究领域

主要从事心血管生物材料研究，包括血管组织工程和缺血性疾病治疗。围绕“血管组织修复再生和血管稳态调控”关键科学问题，利用工程材料科学、化学生物学等新技术、新方法，开展交叉研究。目前，成功制备了具有微/纳米复合纤维结构的人工血管，解决了“细胞化”困难的瓶颈问题。其可通过递送重要血管活性物质诱导血管干/祖细胞的迁移和分化，并首次提出了新型细胞因子Dkk3诱导血管祖细胞迁移的分子机制。发展了一氧化氮的精准递送系统，实现其“定量（可控）释放”和“定点（靶向）”传输，从而有效促进血管新生，成功用于缺血疾病的治疗。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Hou J, Pan Y, Zhu D, Fan Y, Feng G, Wei Y, Wang H, Qin K, Zhao T, Yang Q, Zhu Y, Che Y, Liu Y, Cheng J*, Kong D, Wang PG, Shen J*, Zhao Q*. Targeted delivery of nitric oxide via a “bump-and-hole”-based enzyme-prodrug pair. Nat Chem Biol 2019, 15: 151-60.(IF: 13.843) Issa Bhaloo S, Wu Y, Le Bras A, Yu B, Gu W, Xie Y, Deng J, Wang Z, Zhang Z, Kong D, Hu Y, Qu A, Zhao Q*, Xu Q*. Binding of Dickkopf-3 to CXCR7 enhances vascular progenitor cellmigration and degradable graft regeneration. Circ Res 2018, 123:451-66. (IF: 15.211) Pan Y, Yang J, Wei Y, Wang H, Jiao R, Moraga A, Zhang Z, Hu Y, Kong D, Xu Q, Zeng L*, Zhao Q*. Histone deacetylase 7-derived peptides play a vital role invascular repair and regeneration. Adv Sci 2018, 5:1800006. (IF: 12.441) Feng G, Zhang J, Li Y, Nie Y, Zhu D, Wang R, Liu J, Gao J, Liu N, He N, Du W, Tao H, Xu Y*, Kong D, Zhao Q*, Li Z*. IGF-1C modified hydrogel enhances cell therapy for acute kidney injury. J Am Soc Nephrol 2016, 27: 2357-69. (IF: 8.655) Wei Y, Wu Y, Zhao R, Zhang K, Midgley AC, Kong D, Li Z*, Zhao Q*. MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. Biomaterials2019, 204:13-24. (IF: 8.806) Du W, ZhangK, ZhangS, Wang R, Nie Y, TaoH, HanZ, Liang L,Wang D, LiuJ, Liu N, HanZ, KongD, Zhao Q*, LiZ*. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomesstimulated by a nitric oxide releasing polymer. Biomaterials2017, 133:70-81. (IF: 8.806) Yao X, Liu Y, Gao J, Yang L, Mao D, Stefanitsch C, Li Y, Zhang J, Ou L, Kong D, Zhao Q*, Li Z*. Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials 2015, 60: 130-40. (IF: 8.806) Wang Z, Cui Y, Wang J, Yang X, Wu Y, Wang K, Gao X, Li D, Li Y, Zheng X, Zhu Y, Kong D*, Zhao Q*. The effect of thick fibers and large pores of electrospun poly(ε-caprolactone) vascular grafts on macrophage polarization and arterial regeneration. Biomaterials2014, 35: 5700-10. (IF: 8.806) Zhao Q, Zhang J, Song L, Ji Q, Yao Y, Cui Y, Shen J*, Wang P, Kong D*. Polysaccharide-based biomaterials with on-demand nitric oxide releasing property regulated by enzyme catalysis. Biomaterials2013, 34: 8450-8. (IF: 8.806) Zheng W, Wang Z, Song L, Zhao Q*, Zhang J, Li D, Wang S, Zheng X, Han J, Yang Z, Kong D*. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials 2012, 33: 2880-91. (IF: 8.806) Wang Z, Lu Y, Qin K, Tian Y, Wang J, Zhang J, Cui Y, Wu Y, Hou J, Shen J, Xu Q, Kong D, Zhao Q*. Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug. J Control Release 2015, 210: 179-88. (IF: 7.877) Wang W, Song H, Zhang J, Li P, Li C*, Wang C, Kong D, Zhao Q*. An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform.J Control Release, 2015, 203: 57-66. (IF: 7.877)