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个人简介

王恺于2007.06年在郑州大学生物工程系获得学士学位。随后,考入南开大学生物化学与分子生物专业进行硕士和博士阶段的学习,于2013年6月获得博士学位。2013年7月进入南开大学生物活性材料教育部重点实验室工作, 一直从事小口径人工血管的研究,着力于通过血管材料的结构设计、功能修饰与降解调控来提高小口径血管材料的通畅性与组织再生性。以第一作者或通讯作者在本领域权威期刊Nano Letters;Arteriosclerosis, Thrombosis, and Vascular Biology;Acs Applied Materials & Interfaces;Advanced Healthcare Materials 等杂志发表SCI论文20篇,参编外文专著一部。获得国家授权发明专利1项;申请国家发明专利7项。 教育经历 理学学士2003.09-2007.06 郑州大学 生物技术 理学硕士2007.09-2010.06 南开大学 生物化学与分子生物学 理学博士2010.09-2013.06 南开大学 生物化学与分子生物学 工作经历 讲师 2013.07-2016.12 南开大学生命科学学院 副研究员 2017.01-至今 南开大学生命科学学院

研究领域

1.生物活性人工血管的构建 2.干细胞治疗心血管疾病

近期论文

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(1)Yuna Shang#, Dengke Zhi#, Guowei Feng, Zhongyan Wang, Duo Mao, Shuang Guo, Ruihua Liu, Lulu Liu, Shuhao Zhang, Shenghuan Sun, Kai Wang*, Deling Kong, Jie Gao* ,Zhimou Yang*. Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor‐I. Nano Letters. 2019,DOI: 10.1021/acs.nanolett.8b04406. (2)Qingying Shi, Xin Luo, Ziqi Huang, Adam C. Midgley, Bo Wang, Ruihua Liu, Dengke Zhi,Tingting Wei, Xin Zhou, Mingqiang Qiao, Jun Zhang*, Deling Kong*, Kai Wang*. Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing. Acta Biomaterialia, 2019, 86: 465-479 (3)Muhammad Shafiq, Qiuying Zhang, Dengke Zhi, Kai Wang*, Deling Kong, Dong-Hwee Kim*. In Situ Blood Vessel Regeneration Using SP (Substance P) and SDF (Stromal Cell–Derived Factor)-1α Peptide Eluting Vascular Grafts. Arterioscler Thromb Vasc Biol, 2018,38(7):e117-e134. (4)Kang Qin, Yifan Wu, Yiwa Pan, Kai Wang*, Deling Kong, Qiang Zhao*. Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model. Journal of Visualized Experiments, 2018,136:e57340. (5)Wen Li, Jingrui Chen, Pan Xu, Meifeng Zhu*, Yifan Wu, Zhihong Wang, Tiechan Zhao, Quhan Cheng, Kai Wang*, Guanwei Fan, Yan Zhu, Deling Kong, Long-term evaluation of vascular grafts with circumferentially aligned microfibers in a rat abdominal aorta replacement model. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018, 106(7):2596-2604 (6)Yiwa Pan#, Xin Zhou#, Yongzhen Wei, Qiuying Zhang, Ting Wang, Meifeng Zhu, Wen Li, Rui Huang, Ruming Liu, Jingrui Chen, Guanwei Fan, Kai Wang*, Deling Kong, Qiang Zhao*, Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers. Scientific Reports, 2017, 7: 3615-3626 (7)Zhihong Wang#, Yifan Wu#, Jianing Wang, Chuangnian Zhang, Hongyu Yan, Meifeng Zhu, Kai Wang*, Chen Li, Qingbo Xu, Deling Kong*, Effect of resveratrol on modulation of endothelial cells and macrophages for rapid vascular regeneration from electrospun poly (ε-caprolactone) scaffolds, ACS Applied Materials &Interfaces, 2017, 9 (23):19541-19551 (8)Kai Wang#, Qiuying Zhang#, Liqiang Zhao, Yiwa Pan, Ting Wang, Dengke Zhi, Shaoyang Ma, Peixin Zhang, Tiechan Zhao, Siming Zhang, Wen Li, Meifeng Zhu, Yan Zhu, Zhang Jun*, Mingqiang Qiao*, Deling Kong*, Functional Modification of Electrospun PCL Vascular Grafts with the Fusion Protein VEGF-HGFI Enhanced Vascular Regeneration, ACS Applied Materials & Interfaces, 2017, 9(13): 11415-11427 (9)Lei Zhu#, Kai Wang#, Teng Ma#, Liangliang Huang#, Bing Xia, Shu Zhu, Yafeng Yang, Zhongyang Liu, Xin Quan, Kai Luo, Deling Kong*, Jinghui Huang*, Zhuojing Luo*, Noncovalent Bonding of RGD and YIGSR to an Electrospun Poly(ε-caprolactone) Conduit through Peptide Self-Assembly to Synergistically Promote Sciatic Nerve Regeneration in Rats, Advanced Healthcare Materials, 2017, 2017, 6 (8): 1600860 (10)Liqiang Zhao#, Shaoyang Ma#, Yiwa Pan, Qiuying Zhang, Kai Wang*, Dongmin Song, Xiangxiang Wang, Guowei Feng, Ruming Liu, Haijin Xu, Jun Zhang, Mingqiang Qiao*, Deling Kong, Functional Modification of Fibrous PCL Scaffolds with Fusion Protein VEGF-HGFI Enhanced Cellularization and Vascularization, Advanced Healthcare Materials, 2016, 5(18): 2376-2385 (11)Kai Wang#, Wenting Zheng#, Yiwa Pan, Shaoyang Ma, Yong Guan, Ruming Liu, Meifeng Zhu, Xin Zhou, Jun Zhang, Qiang Zhao, Yan Zhu*, Lianyong Wang*, Deling Kong, Three-layered PCL Grafts Promoted Vascular Regeneration in a Rabbit Carotid Artery Model,Macromolecular Bioscience, 2016, 16(4): 608-618. (12)Huaimin Wang#, Duo Mao#, Youzhi Wang, Kai Wang*, Xiaoyong Yi, Deling Kong, Zhimou Yang, Qian Liu*, Dan Ding*. Biocompatible fluorescent supramolecular nanofibrous hydrogel for long-term cell tracking and tumor imaging applications. Scientific Reports. 2015, 5:16680. (13)Jun An#, Kai Wang#, Siyuan Chen, Meimei Kong, Yuxin Teng, Lianyong Wang, Cunjiang Song, Deling Kong and Shufang Wang*. Biodegradability, cellular compatibility and cell infiltration of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in comparison with poly(ε-caprolactone) and poly(lactide-co-glycolide). Journal of Bioactive and Compatible Polymers. 2015, 30(2): 209-221. (14)Kai Wang, Xuejiao Chen, Yiwa Pan, Yun Cui, Xin Zhou, Deling Kong, Qiang Zhao*, Enhanced Vascularization in Hybrid PCL/Gelatin Fibrous Scaffolds with Sustained Release of VEGF. Biomed Research International, 2015, 2015: 865076-865086 (15)Kai Wang#, Meifeng Zhu#, Ting Li, Wenting Zheng, Li Li, Mian Xu, Qiang Zhao, Deling Kong*, Lianyong Wang*, Improvement of Cell Infiltration in Electrospun Polycaprolactone Scaffolds for the Construction of Vascular Grafts, Journal of Biomedical Nanotechnology, 2014, 10(8): 1588-1598 (16)Kai Wang#, Meng Xu#, Meifeng Zhu, Hong Su, Hongjun Wang*, Deling Kong, Lianyong Wang*, Creation of Macropores in Electrospun Silk Fibroin Scaffolds Using Sacrificial PEO-microparticles to Enhance Cellular Infiltration, Journal of Biomedical Materials Research Part A, 2013, 101(12): 3474-3481 (17)Kai Wang, Yong Guan, Yi Liu, Meifeng Zhu, Ting Li, Di An, Lailiang Ou*, Yongzhe Che, Guorong Zhang, Jun Zhang*, Xi-Long Zheng, Deling Kong. Fibrin Glue with Autogenic Bone Marrow Mesenchymal Stem Cells for Urethral Injury Repair in Rabbit Model. Tissue Engineering: Part A. 2012, 18(23-24):2507-2517. (18)Min Zhang#, Kai Wang#, Zhexiang Wang, Bin Xing, Qiang Zhao*, Deling Kong*. Small-diameter tissue engineered vascular graft made of electrospun PCL/lecithin blend. Journal of Materials Science - Materials in Medicine. 2012, 23(11): 2639-2648.

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