个人简介

Dr. Howard Alper conducts basic research for the synthesis of compounds of value to the pharmaceutical, petrochemical, and commodity chemical industries. His research group also investigates hydroformylation, ring-expansion carbonylation reactions, as well as stereospecific and highly enantioselective cycloaddition reactions of heterocumulenes. He also explores the activity and recyclability of dendrimer-metal complexes as catalysts, including biomimetic based systems. Recyclable transition metal catalysis using ionic liquids is also pursued by his research group.

研究领域

Organic and Biological Chemistry Inorganic and Organometallic Chemistry Catalysis Asymmetric synthesis Dendrimers Cyclization

Development of metal catalyzed homogeneous, phase transfer, and heterogeneous mediated oxidation, reduction, carbonylation and cyclization reactions. These processes are being applied to the synthesis of compounds of value to the petrochemical and/or pharmaceutical industries. Ionic liquids are useful solvents, and sometimes promoters, for some of these reactions. For example, the asymmetric synthesis of -lactams by rhodium (I) catalysts is a remarkable example of a regio, stereo, and enantiospecific reaction. Ring expansion-carbonylation reactions have considerable scope in terms of heteroatom and ring size. Novel palladium catalyzed, stereospecific cycloaddition reactions of heterocumulenes (e.g. carbodiimides, isocyanates) and aziridines or azetidines leads to 5- and 6-membered ring heterocycles difficult or impossible to synthesize by other means. Using chiral ligands results in the formation of products in 88-99 %ee. Recently, dendrimer-metal complexes, anchored to silica, have been found to be excellent, recyclable catalysts for the hydroformylation of olefins. The length of the spacer group in the dendrimer has a significant impact on the activity and recyclability of the dendrimer metal complex. Finally, dendronized and non-dendronized magnetic nanoparticle metal complexes are excellent catalysts for highly regioselective reactions

近期论文

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J.Ferguson, F.Zeng, and H.Alper, Synthesis of Coumarins via Pd-Catalyzed Oxidative Cyclocarbonylation of 2-Vinylphenols, Org.Lett., 14, 5602(2012). K.Okuro and H.Alper, Palladium-Catalyzed Synthesis of 1, 2, 3, 4-Tetrahydro-5H-2-benzazepin- 5-ones, Synlett., 23, 2531(2012). L.L.W.Cheung, G.Vasapollo, and H.Alper, Synthesis of Alcohols via a Rhodium-catalyzed Hydroformylation-Reduction Sequence using Tertiary Bidentate Amine Ligands, Adv. Synth. Catal., 354, 2019(2012). K.Okuro and H.Alper, Palladium-catalyzed Synthesis of 4-Alkoxycarbonyl-3,4-dihydroisoquinolin-1(2H)-ones, Tetrahedron Lett., 53, 4816(2012). K. Okuro and H. Alper, Palladium-Catalyzed Intermolecular Cyclocarbonylation of 2-Iodoanilines with the Michael Acceptor, Diethyl Ethoxycarbonylbutendienoate, J. Org. Chem., 77, 4420(2012). R. Abu-Reziq and H. Alper, Magnetically Separable Base Catalysts: Heterogeneous Catalysis vs Quasi-Homogeneous Catalysis, Appl. Sciences 2, 260 (2012). K. Okuro and H. Alper, Palladium-Catalyzed Intermolecular Cyclocarbonylation of 2-Iodoanilines with N-Toluenesulfonyl Aldimines, Tetrahedron Lett., 53, 2540 (2012). K.Okuro and H.Alper, Ionic Diamine Rhodium Complex Catalyzed Reductive N-Heterocyclization of N-(2-nitroarylidene)amines, Terahedron Lett., 53, 620 (2012). K.Okuro, J.Gurnham and H.Alper, Ionic Diamine Rhodium Complex Catalyzed N-Heterocyclization of 2-Nitrovinylarenes, J.Org.Chem., 76, 4715 (2011). F. Zeng and H.Alper, Palladium-Catalyzed Domino C-S Coupling Carbonylation Reactions: An Efficient Synthesis of 2-Carbonylbenzo[b]thiophene Derivatives, Org. Lett., 13, 2868 (2011). H. Cao, T.O.Vieira and H.Alper, Synthesis of Unsaturated Seven-Membered Ring Lactams through Palladium-Catalyzed Amination and Intramolecular Cyclocarbonylation Reactions of Amines and Baylis-Hillman Acetates, Org. Lett., 13, 11 (2011). F. Zeng and H.Alper, Palladium-Catalyzed Domino Ring Opening/Carboxamidation Reactions of N-Tosyl Aziridines and 2-Iodothiophenols: A Facile And Efficient Approach to 1,4-Benzothiazepin-5-ones, Org. Lett., 12, 5567 (2010) H.Cao and H.Alper, Palladium-Catalyzed Double Carbonylation Reactions of o-Dihaloarenes with Amines in Phosphonium Salt Ionic Liquids, Org. Lett., 12, 4126 (2010) Q.Yang, H.Cao, A.Robertson, and H.Alper, Synthesis of Dibenzo[b,f][1,4]oxazepin-11 (10H )-ones by Intramolecular Cyclocarbonylation Reactions Using PdI2/ Cytop 292 as the Catalytic System, J.Org.Chem., 75, 6297 (2010) F.Zeng and H.Alper, One-Step Synthesis of Quinazolino[3,2-a]quinazolinones via Palladium-Catalyzed Domino Addition/Carboxamidation Reactions, Org. Lett.,12, 3642 (2010) K.Okuro and H. Alper, Ionic Diamine Rhodium Complex Catalyzed Hydroaminomethylation of 2-Allylanilines, Tetrahedron Lett., 51, 4959 (2010) M.Vasylyev and H.Alper, Conventional and Tandem Hydroformylation, Synthesis, 17, 2893 (2010) M. Vasylyev and H. Alper, Rhodium-Catalyzed Reductive Allylation of Conjugated Aldehydes with Allyl Acetate, J.Org.Chem., 75, 2710 (2010) F. Zeng and H. Alper, Tandem Palladium-Catalyzed Addition/ Cyclocarbonylation: An Efficient Synthesis of 2-Heteroquinazolin -4(3H)-ones, Org. Lett., 12, 1188 (2010) G. Chouhan and H. Alper, Domino ring-opening/carboxamidation Reactions of N-Tosyl Aziridines and 2-Halophenols/Pyridinol: Efficient Synthesis of 1,4-Benzo-and Pyrido-oxazepinones, Org. Lett., 12, 192 (2010)