个人简介
李登文,1974年出生,天津人。于1993年进入南开大学微生物系学习。 1997年本科毕业,同年免试继续攻读硕士研究生,研究的主要内容是“酵母金属硫蛋白的研究”,于2000年获得硕士学位。2002年进入南开大学生物化学与分子生物学系,开始博士研究生阶段的学习,研究方向是“组蛋白 H3 磷酸化与细胞有丝分裂的关系研究”,2005年获得博士学位,并留校工作。参与“生物化学”、“普通生物学”等课程的教学工作;科研工作主要集中在细胞形态结构与功能方面的研究,以第一作者在国际和国内核心刊物发表多篇论文。 教育经历 1993.9-1997.7,南开大学,学士; 1997.9-2000.7,南开大学,硕士; 2002.9-2005.7,南开大学,博士。 工作经历 2005.7,留校工作至今。 2008年晋升副教授; 2014年晋升教授。
研究领域
1、细胞运动的调控和生理功能; 2、细胞骨架的动态变化与相关疾病
近期论文
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Xie Songbo, Yang Yang, Lin Xiaochen, Zhou Jun, Li Dengwen*, Liu Min*, Characterization of a novel EB1 acetylation site important for the regulation of microtubule dynamics and cargo recruitment, Journal of Cellular Physiology, 2018, 233(3): 2581-2589 Shi Xingjuan#*, Li Dengwen#, Wang Yujue, Liu Shiyu, Qin, Juan, Wang Jun, Ran Jie, Zhang Yu, Huang Qinghai, Liu Xiangdong, Zhou Jun, Liu Min*, Discovery of centrosomal protein 70 as an important player in the development and progression of breast cancer, American Journal of Pathology, 2017, 187(3): 679-688 Yang Yang, Mu Tianhao, Li Te, Xie Songbo, Zhou Jun, Liu Min*, Li Dengwen*, Effects of FSTL1 on the proliferation and motility of breast cancer cells and vascular endothelial cells, Thoracic Cancer, 2017, 8(6):606-612 Zhang Yijun, Luo Youguang, Lyu Rui, Chen Jie, Liu Ruming, Li Dengwen, Liu Min, Zhou Jun*, Proto-Oncogenic Src Phosphorylates EB1 to regulate the microtubule-focal adhesion crosstalk and stimulate cell migration, Theranostics, 2016, 6(12):2129-2140 Yang Yunfan#, Liu Min#,Li Dengwen#, Ran Jie, Gao Jinmin, SuoShaojun, Sun Shao-Cong, Zhou Jun, CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation,Proceedings of the National Academy of Sciences of the United States of America,2014, 111(6): 2158-2163 LiDengwen#, GaoJinmin#, YangYunfan#, SunLei, SuoShaojun, LuoYouguang, ShuiWenqing, ZhouJun*, LiuMin*, CYLDcoordinates with EB1 to regulate microtubule dynamics and cell migration, Cell Cycle, 2014, 13(6): 974-983 LiDengwen#, SunXiaodong#, ZhangLinlin, YanBing, XieSongbo, LiuRuming, LiuMin, ZhouJun*, Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells, Protein & Cell, 2014, 5(3): 214-223 Zhang Linlin, Liu Ningning, Xie Songbo, He Xianfei, Zhou Jun, LiuMin, Li Dengwen*, HDAC6 regulates neuroblastoma cell migration and may play a role in the invasion process, Cancer Biology & Therapy, 2014, 15(11): 1561-1570 Peng Guoyuan, Ren Yuan, Sun Xiaodong, Zhou Jun, Li Dengwen*, Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration. Biochemical Pharmacology 2012, 83(10):1374-1382 Li Dengwen#, Xie Songbo#, Ren Yuan#, Huo Lihong, Gao Jinmin, Cui Dandan, Liu Min, Zhou Jun*, Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein & Cell 2011, 2(2):150-160