轩维民 - 天津大学 - 生命科学学院

个人简介

教育经历： 2009.8 - 2013.7 美国新墨西哥大学 - 化学 - 博士 2003.9 - 2007.7 天津大学 - 药学 - 学士工作经历： 2022.5- 至今天津大学生命科学学院 → 在职 → 教授 2017.12 - 2021.11 南开大学 → 特聘研究员 2013.8 - 2017.9 美国斯克里普斯研究所 → 博士后

研究领域

基于密码子扩展的化学生物学/合成生物学功能蛋白质的进化与设计基于噬菌体展示的蛋白质/多肽药物研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xiaochen Yang, Lei Zhao, Ying Wang, Yanli Ji, Xun-Cheng Su, Jun-An Ma, Weimin Xuan*, Constructing Photoactivatable Protein with Genetically Encoded Photocaged Glutamic Acid. Angew. Chem. Int. Ed. 2023, DOI:10.1002/anie.202308472. W. Xuan and X. Yang., Chapter “Semi-synthesis of Glutamine-Methylated Proteins Enabled by Genetic Code Expansion” in book “Genetically Incorporated Non-Canonical Amino Acids: Methods and Protocols”. Methods Mol Biol. 2023, 2676:147-156. Xin Chu, Bo Li, Hao-Yang Liu, Xiaowei Sun, Xiaochen Yang, Gang He, Chuanzheng zhou, Weimin Xuan, Shu-Lin Liu*, Gong Chen*, Bioconjugation via Hetero-Selective Clamping of Two Different Amines with ortho-Phthalaldehyde. Angew. Chem. Int. Ed. 2022, 61(31): e202205522. anie.202212199 Qifan Wu, Suwei Dong*, Weimin Xuan*, N-Glycan Engineering: Constructing the N-GlcNAc Stump (invited concept). ChemBioChem, 2023 Jan 3;24(1):e202200388. Conghui Ren,# Qifan Wu,# Ruotong Xiao, Yanli Ji, Xiaochen Yang, Hongqiang Qin, Jun-An Ma, Weimin Xuan*, Expanding the scope of genetically encoded lysine post-translational modifications with lactylation, β-hydroxybutyrylation and lipoylation. ChemBioChem, 2022 Sep 16;23(18):e202200302. Yanli Ji, Lin Sun, Yao Chen, Hongqiang Qin*, Weimin Xuan*, Sirtuin-Derived Covalent binder for the Selective Recognition of Protein Crotonylation. Angew. Chem. Int. Ed. 2022, 61(31): e202205522. Qifan Wu,# Weidong Dong,# Hui Miao, Qian Wang, Suwei Dong,* Weimin Xuan*, Site-Specific Protein Modification with Reducing Carbohydrates, Angew. Chem. Int. Ed. 2022, 61(19): e202116545. Ruotong Xiao, Lei Zhao, Hongpeng Ma, Qiaoli Liu, Hongqiang Qin, Xiaozhou Luo, Weimin Xuan*, Toward an Orthogonal Protein Lysine Acylation and Deacylation System, ChemBioChem, 2022, 23(4): e202100551. Xiaochen Yang, Hui Miao, Ruotong Xiao, Luyao Wang, Yan Zhao, Qifan Wu, Yanli Ji, Juanjuan Du, Hongqiang Qin, Weimin Xuan*, Diverse Protein Manipulations with Genetically Encoded Glutamic Acid Benzyl Ester, Chem. Sci. 2021, 12(28), 9778 – 9785. Wenbing Cao, Xuewen Qin, Yong Wang, Zhen Dai, Xianyin Dai, Haoyu Wang, Weimin Xuan, Yingming Zhang, Yu Liu, Tao Liu, A General Supramolecular Approach to Regulate Protein Functions by Cucurbit[7]uril and Unnatural Amino Acid Recognition, Angew. Chem. Int. Ed. 2021, 60(20):11196-11200. Yanli Ji, Conghui Ren, Hui Miao, Zhili Pang, Ruotong Xiao, Xiaochen Yang and Weimin Xuan*, Genetically Encoding ε-N-Benzoyllysine in Proteins, Chem. Commun. 2021, 57(14), 1798 - 1801. Hui Miao, Chenguang Yu, Anzhi Yao, Weimin Xuan*, Rational design of a function-based selection method for genetically encoding acylated lysine derivatives, Org. Biomol. Chem., 2019, 17(25), 6127 – 6130. Xuan, W.;§ Collins, D.;§ Koh M.; Shao, S.; Yao, A.; Xiao, H.; Garner, PP.; Schultz, PG. Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins. ACS Chem. Biol. 2018, 13 (3), pp 578–581. Xuan, W.;§ Yao, A.;§ Schultz PG. Genetically encoded fluorescent probe for detecting sirtuins in living cells. J. Am. Chem. Soc., 2017, 139 (36), pp 12350–12353. Xuan, W.; Schultz, PG. A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids. Angew. Chem. Int. Ed. 2017, 56(31), 9170-9173. Xuan, W.; Shao, S.; Schultz, PG. Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Aryl Carbamate Side Chains. Angew. Chem. Int. Ed. (hot paper) 2017, 56(18), 5096 –5100. Xuan, W.; Li, J.; Luo, X.; Schultz, PG. Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angew. Chem. Int. Ed. 2016, 55(34), 10065-10068. Xuan, W.; § Pan, R. § (equal contribution); Wei Y.; Cao, Y.; Li, H.; Liang, FS.; Liu, K.; Wang, W. Reaction-based “off-on” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+- induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic Stroke. Bioconjugate Chem., 2016, 27, 302−308. Xiao, H.;§ Xuan, W.§ (equal contribution); Shao, S.; Liu, T.; Schultz, P. G. Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones. ACS Chem. Biol. 2015, 10(7), 1599−1603. Xuan, W.; Cao, Y; Zhou, J.; Wang, W. A FRET-based ratiometric fluorescent and colorimetric probe for the facile detection of organophosphonate nerve agent mimic DCP. Chem. Commun., 2013, 49, 10474—10476. Xuan, W.; Pan, R.; Cao, Y.; Liu, K.; Wang, W. A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells. Chem. Commun., 2012, 48, 10669-10671. Xuan, W.; Chen, C.; Cao. Y.; He, W.; Jiang, W.; Liu, K.; Wang, W. Rational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg2+. Chem. Commun., 2012, 48, 7292–7294. Xuan, W.; Sheng, C.; Cao, Y.; He, W.; Wang, W. Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems (highlights). Angew. Chem. Int. Ed. 2012, 51, 2282 – 2284. Jack C Li, Fariborz Nastertorabi, Weimin Xuan, Gye Won Han, Raymond C Stevens, Peter G Schultz. A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure ACS Chem. Biol. 2019, 14(6), 1150-1153. Luo, X.; Fu, G.; Wang, R.; Zhu, X.; Zambaldo, C.; Liu, R.; Liu, T.; Lyu, X.; Du, J.; Xuan, W.; Yao, A.; Reed SA.; Kang, M.; Zhang Y.; Guo, H.; Huang, C.; Yang, PY.; Wilson, IA.; Schultz, PG.; Wang, F. Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. Nat. Chem. Biol. 2017, 13, 845-849. Zeng, G.; Li, H.; Wei, Y.; Xuan, W.; Zhang, R.; Breden, LE; Wang, W.; Liang, FS. Engineering Iron Responses in Mammalian Cells by Signal-Induced Protein Proximity. ACS Synthetic Biology. 2017, 6 (6), pp 921–927. Maston, L; Jones, D.; Giermakowska, W; Howard, TA; Cannon, JL.; Wang, W.; Wei, Y.; Xuan, W.; Resta, TC.; Gonzalez, B. Central Role of T Helper 17 Cells in Chronic Hypoxia-Induced Pulmonary Hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 2017, 312(5): L609-L624. Luo, X.; Zambaldo, C.; Liu, T.; Zhang, Y.; Xuan, W.; Wang, C.; Reed, S. A.; Yang, PY.; Wang, RE.; Javahishvili, T.; Schultz, PG.; Young, TS. Recombinant thiopeptides containing noncanonical amino acids. Proc. Natl. Acad. Sci. U.S.A., 2016, 113, 3615-20. Cao, Y.; Pan, R.; Xuan, W.; Wei, Y.; Liu, K.; Zhou, J.; Wang, W. Photo-triggered Fluorescent Theranostic Prodrug for DNA Alkylating Agent Mechlorethamine Releasing and Spatiotemporal Monitoring. Org. Biomol. Chem., 2015, 13, 6742-6748. Zeng, G.; Zhang, R.; Xuan, W.; Wang, W.; Liang, FS. Constructing de novo H2O2 Signaling via Induced Protein Proximity. ACS Chem. Biol., 2015, 10 (6), 1404–1410.