RICHTER-ADDO, GEORGE - University of Oklahoma - Department of Chemistry and Biochemistry

个人简介

BS, Dip-Ed, 1982, University of Cape Coast, Ghana PhD, 1988, University of British Columbia, Canada Postdoc, 1988-1989, University of Alberta, Canada; 1989-1991, University of British Columbia, Canada 1992-1993, University of Utah

研究领域

Inorganic nitrogen oxides such as NO, nitrite, and hyponitrite play very important roles in biology. The chemistry of these nitrogen oxides (NOx) is directed by various iron-containing enzymes such as the muscle protein myoglobin, the blood protein hemoglobin, and the liver protein cytochrome P450. The health effects of some of these NOx species includes blood pressure control, cancer, and memory transmission. Importantly, all of these effects depend on the biocoordination chemistry of Fe. Our research involves determining the role that Fe plays in directing the health related chemistry of NOx species such as nitric oxide (NO), nitrite, nitrosamines, nitrosothiols, and hyponitrite. We utilize a range of techniques including (i) inorganic syntheses of chemical and biological intermediates, (ii) advanced electrochemistry and fiber-optic infrared and optical spectroelectrochemistry for the determination of the redox behavior of heme models, (iii) molecular biology and mutagenesis to assess the effects of active site structure on protein function, (iv) structural biology using protein crystallography to determine three-dimensional structures of biomolecules, (v) vibrational and magnetic resonance spectroscopy, and (vi) density-functional theoretical calculations for the elucidation of the electronic structures of biological intermediates.

近期论文

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REVIEW: NOx Linkage Isomerism in Metal Complexes. Awasabisah D, Richter-Addo GB (2015) Adv. Inorg. Chem. Vol. 67; pp 1-86. Crystal structure of chlorido{5,10,15,20-tetrakis[2-(2,2-dimethylpropanamido)phenyl]porphyrinato}iron(III). Awasabisah D, Powell DR, Richter-Addo GB (2015) Acta Cryst. E71; pp m42-m43. PDF Crystal structure of bis(1-methylimidazole)(5,10,15,20-tetraphenylporphyrinato)iron(II) 1-methylimidazole disolvate. Ye G, Powell DR, Richter-Addo GB (2015) Acta Cryst. E71; pp m57-m58. PDF Characterization of the Bridged Hyponitrite Complex {[Fe(OEP)]2(mu-N2O2)}: Reactivity of Hyponitrite Complexes and Biological Relevance. Berto TC, Xu N, Lee SR, McNeil AJ, Alp EE, Zhao J, Richter-Addo GB, Lehnert N. (2014) Inorg. Chem. 53; 6398-6414. doi: http://10.1021/ic5002573. Crystallographic Characterization of the Nitric Oxide Derivative of R-State Human Hemoglobin. Yi J, Soares AS, Richter-Addo GB (2014) Nitric Oxide; Biol. Chem. 34; pp 46-50. LINK doi: http://dx.doi.org/10.1016/j.niox. 2014.04.001 Synthesis, Characterization, and Fiber-optic Infrared Reflectance Spectroelectrochemical Studies of Some Dinitrosyl Iron Diphosphine Complexes Fe(NO)2L2. Jones MW, Powell DR, Richter-Addo GB (2014) J. Organomet. Chem. 754; pp 63-74. LINK (1-Methylimidazole)(o-nitrosotoluene)(5,10,15,20-tetraphenylporphyrinato)iron(II) dichloromethane solvate. Abucayon EG, Awasabisah D, Powell DR, Richter-Addo GB (2014) Acta Cryst. E. 70; pp m51-m52. PDF Synthesis, Molecular Structure, and Spectroelectrochemistry of a Nitrosyl Iron Porphyrin Containing an Unsymmetrical Xanthene-linked Porphyrin Core. Xu N, Powell DR, Richter-Addo GB (2014) Nitric Oxide: Biol. Chem. 37; pp 61-65. LINK REVIEW: Interactions of Nitrosoalkanes/arenes, Nitrosamines, Nitrosothiols, and Alkyl Nitrites with Metals. Xu N, Richter-Addo GB (2014) Prog. Inorg. Chem. 59; Chapter 6, pp 381-445. Link Degradation of Human Hemoglobin by Organic C-Nitroso Compounds. Yi J, Ye G, Thomas LM, Richter-Addo GB (2013) Chem. Commun. 49; pp 11179-11181. Preparation of the Elusive (por)Fe(NO)(O-ligand) Complex by Diffusion of Nitric Oxide into a Crystal of the Precursor. Xu N, Goodrich LE, Lehnert N, Powell DR, Richter-Addo GB (2013) Angew. Chem. Int. Ed. 52; pp 3896-3900. DOI: 10.1002/anie.201208063. LINK (5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrinato)(2,3,5,6-tetrafluorophenolato)iron(III) cyclohexane monosolvate. Xu N, Powell DR, Richter-Addo GB (2013) Acta Cryst. E69; M530-M531. PDF Stable Ruthenium Nitrosyl Porphyins with Axial O-Bonded Ligands; Preparation and Redox Behavior. Awasabisah D, Xu N, Sharmah Gautam KP, Powell DR, Shaw MJ, Richter-Addo GB (2013) Dalton Trans. 42; pp 8537-8540. DOI: 10.1039/c3dt33109a. Selected as Cover Art. LINK (2,3,5,6-tetrafluorophenolato)(5,10,15,20-Tetraphenylporphyrinato)iron(III). Xu N, Powell DR, Richter-Addo GB (2013) Acta Cryst. E69; M564-M565. PDF. Nitric Oxide Coupling Mediated by Iron Porphyrins: the N-N Bond Formation Step is Facilitated by Electrons and a Proton. Yi J, Morrow BH, Campbell AL, Shen JK, Richter-Addo GB (2012) Chem. Commun. 48; pp 9041-9043. LINK Unveiling the Three-Dimensional Structure of the Green Pigment of Nitrite-Cured Meat. Yi J, Richter-Addo GB (2012) Chem. Commun. 48; pp 4172-4174. LINK Cyclic Voltammetric and Fiber-Optic Infrared Spectroelectrochemical Studies of Six-Coordinate (por)Ru(NO)Cl Compounds (por = porphyrinato dianion). El-Attar, MA, Xu N, Awasabisah, D, Powell DR, Richter-Addo GB (2012) Polyhedron 40; pp 105-109. LINK Distal Pocket Control of Nitrite Binding in Myoglobin. Yi J, Thomas, LM, Richter-Addo GB (2012) Angew. Chem. Int. Ed. Engl. 51; pp 3625-3627. LINK Synthesis, Characterization, and Infrared Reflectance Spectroelectrochemistry of Organoruthenium Nitrosyl Porphyrins. Xu N, Lilly J, Powell DR, Richter-Addo GB (2012) Organometallics 31; pp 827-834. LINK Nitrite Reduction by Co(II)- and Mn(II)-Substituted Myoglobins. Towards Understanding the Necessary Components of Mb Nitrite Reductase Activity. Heinecke J, Yi J, Richter-Addo GB, Ford PC (2012) Journal of Inorganic Biochemistry 107; pp 47-53. LINK