MAO, CHUANBIN - University of Oklahoma - Department of Chemistry and Biochemistry

个人简介

BS, 1992, Northeastern University, China PhD, 1998, Northeastern University, China Postdoc, 2000-2005, University of Texas at Austin

研究领域

Our current research is focused on two aspects: (1) the application of biology in nanotechnology and chemistry, and (2) the application of nanotechnology and chemistry in biology and medicine. Specifically, my research group (1) takes advantage of genetic engineering, mineralization and self-assembly of biological macromolecules to build inorganic or bio-inorganic hybrid nanostructures with defined macromolecular architectures and chemical/biological functionalities; (2) mimics biological world to develop novel strategies for the controlled synthesis and assembly of bio-/nano-materials that can be used in energy, photonics and medicine; (3) identifies biomolecular probes that can specifically recognize materials, mammalian cells, and tumor tissues for targeted drug/gene delivery and cancer therapy; AND (4) integrates biological recognition of biomolecular probes and physical/chemical/biological properties of nanomaterials to develop new strategies for bio-imaging and analysis, bone regeneration, targeted drug/gene delivery, and targeted cancer treatment. The following techniques are routinely used in our research: bacterial and mammalian cell culture, molecular cloning, protein expression and purification, phage display, cell surface display, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, bio-nanomaterials synthesis, and bioconjugation.

近期论文

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Wang, M.; Li, M.; Yang, M.; Zhang, X.; Yu, A.; Zhu, Y.; Qiu, P.; Mao, C. B. “NIR-induced highly sensitive detection of latent fingermarks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state.” Nano Research, accepted. Wang, J.; Wang, L.; Yang, M.; Zhu, Y.; Tomsia, A. P.; Mao, C. B. “Untangling the effects of peptide sequences and nanotopographies in a biomimetic niche for directed differentiation of iPSCs by assemblies of genetically engineered viral nanofibers.” Nano Letters, 2014, 14, 6850–6856. Li, M.; Zhu, Y.; Zhang, H.; Li, L.; He, P.; Xia, H.; Zhang, Y.; Mao, C. B. “Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells.” Scientific Reports, 2014, 4, 7380, DOI:10.1038/srep07380. Liao, J.; Zhu, Y.; Yin, Z.; Tan, G.; Ning, C.; Mao, C. B. “Tuning nano-architectures and improving bioactivity of conducting polypyrrole coating on bone implants by incorporating bone-borne small molecules.” Journal of Materials Chemistry B, 2014, 2, 7872-7876. Patty, K.; Sadeghi, S. M.; Campbell, Q.; Hamilton, N.; West, R. G.; Mao, C. B. “Probing the structural dependency of photoinduced properties of colloidal quantum dots using metal-oxide photo-active substrates.” Journal of Applied Physics, 2014, 116, 114301. (Featured as a story "Making quantum dots glow brighter" at Science Daily and American Institute of Physics) Liao, J.; Zhu, Y.; Zhou, Z.; Chen, J.; Tan, G.; Ning, C.; Mao, C. B. “Reversibly controlling preferential protein adsorption on bone implants by using an applied weak potential as a switch.” Angewandte Chemie International Edition, 2014, 53, 13068-13072. Rajala, A.; Wang, Y.; Zhu, Y.; Ranjo-Bishop, M.; Ma, J. X.; Mao, C. B.; Rajala, R. V. S. “Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo.” Nano Letters, 2014, 14, 5257-5263. Yang, M.; Shuai, Y.; Zhou, G.; Mandal, N.; Zhu, L.; Mao, C. B. “Tuning molecular weights of Bombyx mori (B. mori) silk sericin to modify its assembly structures and materials formation.” ACS Applied Materials & Interfaces, 2014, 6, 13782-13789. Li, L.; Li, M.; Li, D.; He, P.; Xia, H.; Zhang, Y.; Mao, C. B. “ Chemical functionalization of bone implants with nanoparticle-stabilized chitosan and methotrexate for inhibiting both osteoclastoma formation and bacterial infection.” Journal of Materials Chemistry B, 2014, 2, 5952-5961. (Back cover) Polini, A.; Wang, J.; Bai, H.; Zhu, Y.; Tomsia, A. P.; Mao, C. B. “Stable biofunctionalization of hydroxyapatite (HA) surfaces by HA-binding/osteogenic modular peptides for inducing osteogenic differentiation of mesenchymal stem cells.” Biomaterials Science, 2014, 2, 1779-1786. Hao, L.; Yang, H.; Du, C.; Fu, X.; Zhao, N.; Xu, S.; Cui, F.; Mao, C. B.; Wang, Y. “Directing the fate of human and mouse mesenchymal stem cells by hydroxyl-methyl mixed self-assembled monolayers with varying wettability.” Journal of Materials Chemistry B, 2014, 2, 4794-4801. (Front cover) Cao, B.; Yang, M.; Zhu, Y.; Qu, X.; Mao, C. B. “Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy,” Advanced Materials, 2014, 26, 4627-4631. Wang, J.; Yang, M.; Zhu, Y.; Wang, L.; Tomsia, A. P.; Mao, C. B. “Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.” Advanced Materials, 2014, 26, 4961-4966. Yang, M.; Shuai, Y.; Zhang, C.; Chen, Y.; Zhu, L.; Mao, C. B.; Ouyang, H. “Biomimetic nucleation of hydroxyapatite crystals mediated by Antheraea pernyi (A. pernyi) silk sericin promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells.” Biomacromolecules, 2014, 15, 1185-1193. Patty, K. D.; Sadeghi, S. M.; Nejat, A.; Mao, C. B. “Enhancement of emission efficiency of colloidal CdSe quantum dots on silicon substrate via an ultra-thin layer of aluminum oxide.” Nanotechnology, 2014, 25, 155701. Sadeghi, S. M.; Hood, B.; Patty, K. D.; Mao, C. B. “Theoretical investigation of optical detection and recognition of single biological molecules using coherent dynamics of exciton-plasmon coupling.” Journal of Physical Chemistry C. 2013, 117, 17344-17351. Gandra, N.; Wang, D-D.; Zhu, Y.; Mao, C. B. “Virus-mimetic cytoplasma cleavable nanoclusters for enhanced gene delivery to mesenchymal stem cells.” Angewandte Chemie International Edition, 2013, 52:11278-11281. Li, D.; Mao, C. B. “One-pot synthesis of surface roughness controlled hollow silica spheres with enhanced drug loading and release profile under ambient conditions in aqueous solutions.” Journal of Materials Chemistry B, 2013, 1, 5515-5520. Muragensan, M.; Abbineni, G.; Nimmo, S.; Cao, B.; Mao, C. B. “Virus-based photo-responsive nanowires formed by linking site-directed mutagenesis and chemical reaction,” Scientific Reports, 2013, 3, 1820, DOI: 10.1038/srep01820. Wang, J.; Wang, L.; Li, X.; Mao, C. B. "Virus activated artificial ECM induces the osteogenic differentiation of mesenchymal stem cells without osteogenic supplements." Scientific Reports, 2013, 3, 1242, DOI:10.1038/srep01242.