LI, JUN - University of Oklahoma - Department of Chemistry and Biochemistry

个人简介

BS, 1991, Nanjing University, China PhD, 1999, Oklahoma State University Postdoc, 2003, The Jackson Laboratory

研究领域

Nearly 2/3 of world population is at the risk of malaria. Half billion malaria cases occur every year and more than one million people died of malaria annually. Malaria is transmitted by anopheline mosquitoes. Passage of the malaria parasites through the vector mosquitoes is an obligatory step for malaria transmission. The process begins when the mosquito ingests a blood meal, and it ends ten days later when malaria sporozoites invade the mosquito's salivary glands. During this time, there are numerous critical interactions between the parasite and mosquito. The parasite locates and invades specific cell types, undergoes radical structural metamorphoses, and carries out global switches in gene expression, while avoiding destruction by the mosquito immune system. The long-term goal of our research is developing a novel vector-based strategy to prevent malaria transmission by interfering with parasite-mosquito interactions using genomics approaches. The short-term goal of our research is to identify the genes causing malaria resistance in Anopheles mosquitoes. Bioinformatics, molecular biology and field research are three components in our lab.

近期论文

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Anopheles midgut FREP1 mediates Plasmodium invasion Genwei Zhang, Guodong Niu, Caio M. Franca, Yuemei Dong, Xiaohong Wang, Noah S. Butler, George Dimopoulos, Jun Li JBC. Under revision Constructing a genome-wide LD map of wild A. gambiae using next-generation sequencing Xiaohong Wang, Yaw A. Afrane, Guiyun Yan, Jun Li BioMed Research International. In press Co-inhibitory and co-stimulatory crosstalk regulates helper T cell differentiation and humoral immunity during Plas modium infection Ryan A. Zander, Nyamekye Obeng-Adjei, Jenna J. Guthmiller, Divine Kulu, Jun Li, Aissata Ongoiba, Boubacar Traore, P eter D. Crompton and Noah S. Butler Cell Host & Microbe. In Press Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae Jun Li, Xiaohong Wang, Genwei Zhang, John I. Githure, Guiyun Yan, Anthony A. James PNAS 110(5):20675-20680.(2013) Genomic law-guided gene prediction in fungi and metazoan. Yaping Fang, Jun Li IJCBDD 6:157 (2013) Comparative Transcriptome Analyses of Deltamethrin-Resistant and -Susceptible Anopheles gambiae Mosquitoes from Kenya by RNA-Seq. Mariangela Bonizzoni, Yaw Afrane, William Augustine Dunn, Francis K. Atieli, Goufa Zhou, Daibin Zhong, Jun Li, Andrew Githeko, Guiyun Yan PLoS ONE 7(9): e44607 (2012). Allelic gene structure variations in Anopheles gambiae mosquitoes. Jun Li, Jose Ribeiro, Guiyun Yan PLoS ONE 5(5): e10699 (2010). Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Riehle, M.M., Markianos, K., Niare, O., Xu, J., Li, J., Toure, A.M., Podiougou, B., Oduol, F., Diawara, S., Diallo, M., Coulibaly, B., Ouatara, A., Kruglyak, L., Traore, S.F., and Vernick, K.D. Science 312, 577-9 (2006). Anopheles gambiae genome reannotation through synthesis of ab initio and comparative gene prediction algorithms. Li, J., Riehle, M.M., Zhang, Y., Xu, J., Oduol, F., Gomez, S.M., Eiglmeier, K., Ueberheide, B.M., Shabanowitz, J., Hunt, D.F., Ribeiro, J.M., and Vernick, K.D. Genome Biol 7, R24 (2006). Molecular genetics of mosquito resistance to malaria parasites. Vernick, K.D., Oduol, F., Lazzaro, B.P., Glazebrook, J., Xu, J., Riehle, M., and Li, J. Curr Top Microbiol Immunol 295, 383-415 (2005). A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands. Korochkina, S., Barreau, C., Pradel, G., Jeffery, E., Li, J., Natarajan, R., Shabanowitz J., Hunt D., Frevert U. and Vernick, K.D. Cellular Microbiology. 8(1), 163 (2006)