Buchwald, Stephen Leffler - Massachusetts Institute of Technology

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Stephen L. Buchwald was born (1955) in Bloomington, Indiana. He received his Sc.B. degree from Brown University in 1977 where he worked with Kathlyn A. Parker and David E. Cane at Brown University as well as Professor Gilbert Stork at Columbia University. He entered Harvard University as a National Science Foundation Predoctoral Fellow in 1977 and received his Ph.D. in 1982. His thesis work, with Jeremy R. Knowles, concerned the mechanism of phosphoryl transfer reactions in chemistry and biochemistry. He then was a Myron A. Bantrell postdoctoral fellow at Caltech with Professor Robert H. Grubbs where he studied titanocene methylenes as reagents in organic synthesis and the mechanism of Ziegler-Natta polymerization. In 1984 he began as an assistant professor of chemistry MIT. He was promoted to the associate professor (1989) and to Professor (1993) and was named the Camille Dreyfus Professor in 1997. In July 2015, he became Associate Head of the Chemistry Department at MIT. During his time at MIT he has received numerous honors including the Harold Edgerton Faculty Achievement Award of MIT, an Arthur C. Cope Scholar Award, the 2000 Award in Organometallic Chemistry from the American Chemical Society and a MERIT award from the National Institutes of Health. He has also been the recipient of the Bristol-Myers Squibb Distinguished Achievement Award and the CAS Science Spotlight Award, both received in 2005 and the American Chemical Society's Award for Creative Work in Synthetic Organic Chemistry as well as the Siegfried Medal Award in Chemical Methods which Impact Process Chemistry, both received in 2006. In 2010 he received the Gustavus J. Esselen Award for Chemistry in the Public Interest. He received the 2013 Arthur C. Cope Award from the American Chemical Society. In 2014 he was the recipient of the Linus Pauling Medal Award and the Ulysses Medal (University College Dublin). In 2015 he received an honorary doctoral degree from the University of South Florida, and also received the BBVA Frontiers in Knowledge Award in Basic Sciences (2014 Award). He was recently selected to receive the 2016 William H. Nichols Medal. In 2000, he was elected as a fellow of the American Academy of Arts and Sciences and in 2008 he was elected as a member of the National Academy of Science. He is the coauthor of over 435 published or accepted papers and 47 issued patents. He serves as a consultant to a number of companies and is an associate editor of Advanced Synthesis and Catalysis.

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B.J. Reizman; Y.M. Wang; S.L. Buchwald; K.F. Jensen, Suzuki-Miyaura cross-coupling optimization enabled by automated feedback, Reaction Chemistry & Engineering, 2016 R.Y. Liu; Y. Yang; S.L. Buchwald, Regiodivergent and Diastereoselective CuH-Catalyzed Allylation of Imines with Terminal Allenes, Angew. Chem. Int. Ed., 2016 P. Ruiz-Castillo; S.L. Buchwald, Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions, Chem. Rev., 2016 A.C. Sather; S.L. Buchwald, The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination, Acc. of Chem. Res., 2016 P.L. Arrechea; S.L. Buchwald, Biaryl Phosphine Based Pd(II) Amido Complexes: The Effect of Ligand Structure on Reductive Elimination, J. Am. Chem. Soc., 2016 N.H. Park; T.J. Senter; S.L. Buchwald, Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz–Schiemann Reaction, Angew. Chem. Int. Ed., 2016 B. M. Vincent; J.B. Langlois; R. Srinivas; A. K. Lancaster; R. Scherz-Shouval; L. Whitesell; B. Tidor; S. L. Buchwald; S. Lindquist, A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance, Cell Chem. Bio., 2016 S.M. King; S.L. Buchwald, Development of a Method for the N-Arylation of Amino Acid Esters with Aryl Triflates, Org. Lett., 2016 W. Huang; S.L. Buchwald, Palladium catalyzed N-Arylation of Iminodibenzyls and Iminostilbenes with Aryl and Hetero-Aryl Halides, Chem. Eur. J., 2016 Y. Yang; I.B. Perry; S.L. Buchwald, Copper-Catalyzed Enantioselective Addition of Styrene-Derived Nucleophiles to Imines Enabled by Ligand-Controlled Chemoselective Hydrocupration, J. Am. Chem. Soc., 2016 S. Roesner; S.L. Buchwald, Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes, Angew. Chem. Int. Ed., 2016 S.D. Friis; M.T. Pirnot; S.L. Buchwald, Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis, J. Am. Chem. Soc., 2016 E.B. Corcoran; M.T. Pirnot; S. Lin; S.D. Dreher; D.A. DiRocco; I.W. Davies; S.L. Buchwald; D.W.C. MacMillan, Aryl amination using ligand-free Ni(II) salts and photoredox catalysis, Science, 2016 Y. Yang; I.B. Perry; G. Lu; P. Liu; S.L. Buchwald, Copper-Catalyzed Asymmetric Addition of Olefin-Derived Nucleophiles to Ketones, Science, 2016 J.S. Bandar; E. Ascic; S.L. Buchwald, Enantioselective CuH-Catalyzed Reductive Coupling of Aryl Alkenes and Activated Carboxylic Acids, J. Am. Chem. Soc., 2016 S.M. Smith; S.L. Buchwald, Regioselective 2-Amination of Polychloropyrimidines, Org. Lett., 2016 Y.M. Wang; S.L. Buchwald, Enantioselective CuH-Catalyzed Hydroallylation of Vinylarenes, J. Am. Chem. Soc., 2016 S.L. Shi; Z.L. Wong; S.L. Buchwald, Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols, Nature, 2016 J.C. Yang; D. Niu; B.P. Karsten; F. Lima; S.L. Buchwald, Use of a “Catalytic” Cosolvent, N,N-Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch, Angew. Chem. Int. Ed., 2016 S. Zhu; N. Niljianskul; S.L. Buchwald, A direct approach to amines with remote stereocentres by enantioselective CuH-catalysed reductive relay hydroamination, Nat. Chem., 2016 V.R. Bhonde; B.T. O'Neill; S.L. Buchwald, An Improved System for the Aqueous Lipshutz–Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles, Angew. Chem. Int. Ed., 2015 M.T. Pirnot; Y.M. Wang; S.L. Buchwald, Copper Hydride-Catalyzed Hydroamination of Alkenes and Alkynes, Angew. Chem. Int. Ed., 2015 J.S. Bandar; M.T. Pirnot; S.L. Buchwald, Mechanistic Studies Lead to Dramatically Improved Reaction Conditions for the Cu-Catalyzed Asymmetric Hydroamination of Olefins, J. Am. Chem. Soc., 2015 E.V. Vinogradova; C. Zhang; A.M. Spokoyny; B.L. Pentelute; S.L. Buchwald, Organometallic palladium reagents for cysteine bioconjugation, Nature, 2015 A.C. Sather; H.Geun Lee; V.Y. De La Rosa; Y. Yang; P. Müller; S.L. Buchwald, A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides, J. Am. Chem. Soc., 2015 P.J. Milner; Y. Yang; S.L. Buchwald, In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides, Organometallics, 2015 A.C. Sather; H.Geun Lee; J.R. Colombe; A. Zhang; S.L. Buchwald, Dosage delivery of sensitive reagents enables glove-box-free synthesis, Nature, 2015 Y.M. Wang; N.C. Bruno; Á.L. Placeres; S. Zhu; S.L. Buchwald, Enantioselective Synthesis of Carbo- and Heterocycles Through a CuH-Catalyzed Hydroalkylation Approach, J. Am. Chem. Soc., 2015 D.T. Cohen; C. Zhang; B.L. Pentelute; S.L. Buchwald, An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides, J. Am. Chem. Soc., 2015 D. Niu; S.L. Buchwald, Design of Modified Amine Transfer Reagents Allows the Synthesis of α-Chiral Secondary Amines via CuH-Catalyzed Hydroamination, J. Am. Chem. Soc., 2015 Y. Yang; S.L. Shi; D. Niu; P. Liu; S.L. Buchwald, Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines, Science, 2015 J.R. Colombe; R. DeBergh; S.L. Buchwald, Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6-Trichlorophenyl Chlorosulfate, Org. Lett., 2015 R. Zhu; S.L. Buchwald, Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes, J. Am. Chem. Soc., 2015 N.H. Park; E.V. Vinogradova; D.S. Surry; S.L. Buchwald, Design of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines, Angew. Chem. Int. Ed., 2015 E. Ascic; S.L. Buchwald, Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines, J. Am. Chem. Soc., 2015 P. Ruiz-Castillo; D.G. Blackmond; S.L. Buchwald, Rational Ligand Design for the Arylation of Hindered Primary Amines Guided by Reaction Progress Kinetic Analysis, J. Am. Chem. Soc., 2015 H.Geun Lee; P.J. Milner; M.S. Placzek; S.L. Buchwald; J.M. Hooker, Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes, J. Am. Chem. Soc., 2015 D.T. Cohen; S.L. Buchwald, Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media, Org. Lett., 2015 S.L. Shi; S.L. Buchwald, Palladium-Catalyzed Intramolecular C-H Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-oxindoles, Angew. Chem. Int. Ed., 2015 S.L. Shi; S.L. Buchwald, Copper-catalysed Selective Hydroamination Reactions of Alkynes, Nat. Chem., 2015 N. Niljianskul; S. Zhu; S.L. Buchwald, Enantioselective Synthesis of α-Aminosilanes by Copper-Catalyzed Hydroamination of Vinylsilanes, Angew. Chem. Int. Ed., 2015 S. Zhu; S.L. Buchwald, Enantioselective CuH-Catalyzed Anti-Markovnikov Hydroamination of 1,1-Disubstituted Alkenes, J. Am. Chem. Soc., 2014 M. Chen; S. Ichikawa; S.L. Buchwald, Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions, Angew. Chem. Int. Ed., 2014 P.J. Milner; T. Kinzel; Y. Zhang; S.L. Buchwald, Studying Regioisomer Formation in the Pd-Catalyzed Fluorination of Aryl Triflates by Deuterium Labeling, J. Am. Chem. Soc., 2014 Y. Yang; K. Niedermann; C. Han; S.L. Buchwald, Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides, Org. Lett., 2014 S.D. Friis; T. Skrydstrup; S.L. Buchwald, Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst, Org. Lett., 2014 J.B. Ernst; N.E.S. Tay; N.T. Jui; S.L. Buchwald, Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas, Org. Lett., 2014 H.Geun Lee; P.J. Milner; M.T. Colvin; L. Andreas; S.L. Buchwald, Structure and reactivity of [(L·Pd)n·(1,5-cyclooctadiene)] (n = 1–2) complexes bearing biaryl phosphine ligands, Inorganica Chimica Acta, 2014 C.Wai Cheung; S.L. Buchwald, Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst, J. Org. Chem., 2014 N.C. Bruno; N. Niljianskul; S.L. Buchwald, N-Substituted 2-Aminobiphenylpalladium Methanesulfonate Precatalysts and Their Use in C–C and C–N Cross-Couplings, J. Org. Chem., 2014 Y. Yang; S.L. Buchwald, Copper-Catalyzed Regioselective ortho C–H Cyanation of Vinylarenes, Angew. Chem. Int. Ed., 2014 Y. Zhu; S.L. Buchwald, Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents, J. Am. Chem. Soc., 2014 H.Geun Lee; P.J. Milner; S.L. Buchwald, Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides, J. Am. Chem. Soc., 2014 M.J. Su; N. Hoshiya; S.L. Buchwald, Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides, Org. Lett., 2014 E.V. Vinogradova; P. Müller; S.L. Buchwald, Structural Reevaluation of the Electrophilic Hypervalent Iodine Reagent for Trifluoromethylthiolation Supported by the Crystalline Sponge Method for X-ray Analysis, Angew. Chem. Int. Ed., 2014 N.H. Park; G. Teverovskiy; S.L. Buchwald, Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates, Org. Lett., 2014 C.Yeun Chung; V. Khurana; P.K. Auluck; D.F. Tardiff; J.R. Mazzulli; F. Soldner; V. Baru; Y. Lou; Y. Freyzon; S. Cho; A.E. Mungenast; J. Muffat; M. Mitalipova; M.D. Pluth; N.T. Jui; B. Schüle; S.J. Lippard; L.H. Tsai; D. Krainc; S.L. Buchwald; R. Jaenisch; S. Lindquist, Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons, Science, 2013 D.F. Tardiff; N.T. Jui; V. Khurana; M.A. Tambe; M.L. Thompson; C.Yeun Chung; H.B. Kamadurai; H.Tae Kim; A.K. Lancaster; K.A. Caldwell; G.A. Caldwell; J.C. Rochet; S.L. Buchwald; S. Lindquist, Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons, Science, 2013 J.R. Colombe; S. Bernhardt; C. Stathakis; S.L. Buchwald; P. Knochel, Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions, Org. Lett., 2013 Y. Yang; T.J.L. Mustard; P.HaYeon Cheong; S.L. Buchwald, Palladium-Catalyzed Completely Linear-Selective Negishi Cross-Coupling of Allylzinc Halides with Aryl and Vinyl Electrophiles, Angew. Chem. Int. Ed., 2013 H.Geun Lee; P.J. Milner; S.L. Buchwald, An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates, Org. Lett., 2013 S. Zhu; N. Niljianskul; S.L. Buchwald, Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes, J. Am. Chem. Soc., 2013 R. Zhu; S.L. Buchwald, Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes, Angew. Chem. Int. Ed., 2013 M. Chen; S.L. Buchwald, Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System, Angew. Chem. Int. Ed., 2013 N.T. Jui; S.L. Buchwald, Cascade Palladium Catalysis: A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazoles, Angew. Chem. Int. Ed., 2013 T.D. Senecal; W. Shu; S.L. Buchwald, A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides, Angew. Chem. Int. Ed., 2013 A. Düfert; K.L. Billingsley; S.L. Buchwald, Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation, J. Am. Chem. Soc., 2013 C.Wai Cheung; S.L. Buchwald, Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst, Org. Lett., 2013 R. DeBergh; N. Niljianskul; S.L. Buchwald, Synthesis of Aryl Sulfonamides via Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids, J. Am. Chem. Soc., 2013 Y. Yang; S.L. Buchwald, Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki–Miyaura Cross-Coupling of Allylboronates and Aryl Halides, J. Am. Chem. Soc., 2013 C.Wai Cheung; D.S. Surry; S.L. Buchwald, Mild and Highly Selective Palladium-Catalyzed Monoarylation of Ammonia Enabled by the Use of Bulky Biarylphosphine Ligands and Palladacycle Precatalysts, Org. Lett., 2013 N.C. Bruno; S.L. Buchwald, Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands, Org. Lett., 2013 E.V. Vinogradova; N.H. Park; B.P. Fors; S.L. Buchwald, Palladium-Catalyzed Synthesis of N-Aryl Carbamates, Org. Lett., 2013 M. Chen; S.L. Buchwald, Continuous-Flow Synthesis of 1-Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a C—N Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence, Angew. Chem. Int. Ed., 2013 X. Wang; S.L. Buchwald, Synthesis of Optically Pure 2-Trifluoromethyl Lactic Acid by Asymmetric Hydroformylation, J. Org. Chem., 2013 A. DeAngelis; D.H. Wang; S.L. Buchwald, Mild and Rapid Pd-Catalyzed Cross-Coupling with Hydrazine in Continuous Flow: Application to the Synthesis of Functionalized Heterocycles, Angew. Chem. Int. Ed., 2013 N.C. Bruno; M.T. Tudge; S.L. Buchwald, Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions, Chem. Sci., 2013 A.M. Spokoyny; C.D. Lewis; G. Teverovskiy; S.L. Buchwald, Extremely Electron-Rich, Boron-Functionalized, Icosahedral Carborane-Based Phosphinoboranes, Organometallics, 2012 P.J. Milner; T.J. Maimone; M. Su; P. Müller; S.L. Buchwald, Investigating the Dearomative Rearrangement of Biaryl Phosphine-Ligated Pd(II) Complexes, J. Am. Chem. Soc., 2012 Y. Yang; N.J. Oldenhuis; S.L. Buchwald, Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts, Angew. Chem. Int. Ed., 2013 S. Ueda; S.L. Buchwald, Catalyst-controlled chemoselective arylation of 2-aminobenzimidazoles, Angew. Chem., Int. Ed., 2012 M.A. Oberli; S.L. Buchwald, A general method for Suzuki-Miyaura coupling reactions using lithium triisopropyl borates, Org. Lett., 2012 C.W. Cheung; S.L. Buchwald, Room temperature copper(II)-catalyzed oxidative cyclization of enamides to 2,5-disubstituted oxazoles via vinylic C-H functionalization, J. Org. Chem., 2012 L. Pellegatti; S.L. Buchwald, Continuous-Flow Preparation and Use of β-Chloro Enals Using the Vilsmeier Reagent, Org. Process Res. Dev., 2012 R. Zhu; S.L. Buchwald, Copper-catalyzed oxytrifluoromethylation of unactivated alkenes, J. Am. Chem. Soc., 2012 N. Chernyak; S.L. Buchwald, Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts, J. Am. Chem. Soc., 2012 M.A. McGowan; C.Z. McAvoy; S.L. Buchwald, Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives, Org. Lett., 2012 E.V. Vinogradova; B.P. Fors; S.L. Buchwald, Palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate: a practical synthesis of unsymmetrical ureas, J. Am. Chem. Soc., 2012 N. Hoshiya; S.L. Buchwald, An Improved Synthesis of BrettPhos- and RockPhos-Type Biarylphosphine Ligands, Adv. Synth. Catal., 2012 W. Shu; S.L. Buchwald, Enantioselective β-arylation of ketones enabled by lithiation/borylation/1,4-addition sequence under flow conditions, Angew. Chem. Int. Ed., 2012 M. Su; S.L. Buchwald, A bulky biaryl phosphine ligand allows for palladium-catalyzed amidation of five-membered heterocycles as electrophiles, Angew. Chem. Int. Ed., 2012 A.T. Parsons; T.D. Senecal; S.L. Buchwald, Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates, Angew. Chem. Int. Ed., 2012 M.A. McGowan; J.L. Henderson; S.L. Buchwald, Palladium-Catalyzed N-Arylation of 2-Aminothiazoles, Org. Lett., 2012 S. Ueda; S. Ali; B.P. Fors; S.L. Buchwald, Me3(OMe)tBuXPhos: a surrogate ligand for Me4tBuXPhos in palladium-catalyzed C-N and C-O bond-forming reactions, J. Org. Chem., 2012 L. Salvi; N. Davis; A. Siraj; S.L. Buchwald, A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers Under Mild Conditions, Org. Lett., 2012 R. Zhu; S.L. Buchwald, Combined oxypalladation/C-H functionalization: palladium(II)-catalyzed intramolecular oxidative oxyarylation of hydroxyalkenes, Angew. Chem. Int. Ed., 2012 S. Ueda; M. Su; S.L. Buchwald, Completely N1-selective palladium-catalyzed arylation of unsymmetric imidazoles: application to the synthesis of nilotinib, J. Am. Chem. Soc., 2012 A.T. Parsons; S.L. Buchwald, Organic chemistry: A radical approach to diversity, Nature, 2011 E.J. Cho; S.L. Buchwald, The palladium-catalyzed trifluoromethylation of vinyl sulfonates, Org. Lett., 2011 X. Wang; S.L. Buchwald, Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins, J. Am. Chem. Soc., 2011 T.J. Maimone; P.J. Milner; T. Kinzel; Y. Zhang; M.K. Takase; S.L. Buchwald, Evidence for in situ Catalyst Modification during the Pd-Catalyzed Conversion of Aryl Triflates to Aryl Fluorides, J. Am. Chem. Soc., 2011 J. Pan; X. Wang; Y. Zhang; S.L. Buchwald, An improved palladium-catalyzed conversion of aryl and vinyl triflates to bromides and chlorides, Org. Lett., 2011 W. Shu; L. Pellegatti; M.A. Oberli; S.L. Buchwald, Continuous-flow synthesis of biaryls enabled by multistep solid-handling in a lithiation/borylation/Suzuki-Miyaura cross-coupling sequence, Angew. Chem. Int. Ed., 2011 D. Tsvelikhovsky; S.L. Buchwald, Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues, J. Am. Chem. Soc., 2011 W. Shu; S.L. Buchwald, Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions, Chem. Sci., 2011 X. Wu; B.P. Fors; S.L. Buchwald, A single phosphine ligand allows palladium-catalyzed intermolecular C-O bond formation with secondary and primary alcohols, Angew. Chem. Int. Ed., 2011 A.T. Parsons; S.L. Buchwald, Copper-catalyzed trifluoromethylation of unactivated olefins, Angew. Chem. Int. Ed., 2011 T. Noël; T.J. Maimone; S.L. Buchwald, Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor, Angew. Chem. Int. Ed., 2011 S. Ueda; M. Su; S.L. Buchwald, Highly N2-selective palladium-catalyzed arylation of 1,2,3-triazoles, Angew. Chem. Int. Ed., 2011 J. Pan; M. Su; S.L. Buchwald, Palladium(0)-catalyzed intermolecular amination of unactivated C(sp(3))-H bonds, Angew. Chem. Int. Ed., 2011 T. Noel; S.L. Buchwald, Cross-coupling in flow, Chem. Soc. Rev., 2011 P. Li; S.L. Buchwald, Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence, Angew. Chem. Int. Ed., 2011 S. Rousseaux; J. Garcia-Fortanet; M.A.Del Agu Sanchez; S.L. Buchwald, Palladium(0)-catalyzed arylative dearomatization of phenols, J. Am. Chem. Soc., 2011 S. Breitler; N.J. Oldenhuis; B.P. Fors; S.L. Buchwald, Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions, Org. Lett., 2011 G. Teverovskiy; D.S. Surry; S.L. Buchwald, Pd-catalyzed synthesis of Ar-SCF3 compounds under mild conditions, Angew. Chem. Int. Ed., 2011 T. Noël; S. Kuhn; A.J. Musacchio; K.F. Jensen; S.L. Buchwald, Suzuki–Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction, Angew. Chem. Int. Ed., 2011 T.D. Senecal; A.T. Parsons; S.L. Buchwald, Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling, J. Org. Chem., 2011 B.P. Fors; S.L. Buchwald, Commentary on "A New, Efficient and Recyclable Lanthanum(III) Oxide-Catalyzed C-N Cross-Coupling" by S. Narayana Murthy, B. Madhav, V. Prakash Reddy, and Y. V. D. Nageswar, Adv. Synth. Catal. 2010, 352, 3241-3245, Adv. Synth. Catal., 2010 T. Noël; J.R. Naber; R.L. Hartman; J.P. McMullen; K.F. Jensen; S.L. Buchwald, Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation, Chem. Sci., 2011 B.P. Fors; S.L. Buchwald, A Multiligand Based Pd Catalyst for C−N Cross-Coupling Reactions, J. Am. Chem. Soc., 2010 J.R. Naber; S.L. Buchwald, Packed-bed reactors for continuous-flow C-N cross-coupling, Angew. Chem. Int. Ed., 2010 J.L. Henderson; S.L. Buchwald, Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization, Org. Lett., 2010 J.L. Henderson; S.M. McDermott; S.L. Buchwald, Palladium-Catalyzed Amination of Unprotected Halo-7-azaindoles, Org. Lett., 2010 X. Shen; A.M. Hyde; S.L. Buchwald, Palladium-Catalyzed Conversion of Aryl and Vinyl Triflates to Bromides and Chlorides, J. Am. Chem. Soc., 2010 D. Tsvelikhovsky; S.L. Buchwald, Synthesis of Heterocycles via Pd-Ligand Controlled Cyclization of 2-Chloro-N-(2-vinyl)aniline: Preparation of Carbazoles, Indoles, Dibenzazepines and Acridines, J. Am. Chem. Soc., 2010 T. Kinzel; Y. Zhang; S.L. Buchwald, A New Palladium Precatalyst Allows for the Fast Suzuki−Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids, J. Am. Chem. Soc., 2010 R.L. Hartman; J.R. Naber; N. Zaborenko; S.L. Buchwald; K.F. Jensen, Overcoming the Challenges of Solid Bridging and Constriction during Pd-Catalyzed C-N Bond Formation in Microreactors, Org. Process Res. Dev., 2010 D.S. Surry; S.L. Buchwald, Dialkylbiaryl Phosphines in Pd-Catalyzed Amination: A User's Guide, Chem. Sci., 2011 D. Maiti; B.P. Fors; J.L. Henderson; Y. Nakamura; S.L. Buchwald, Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases, Chem. Sci., 2011

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