CICHEWICZ, ROBERT - University of Oklahoma - Department of Chemistry and Biochemistry

个人简介

BS, 1994, Grand Valley State University Ph D, 2002, Michigan State University Postdoc, 2002-2005, University of California, Santa Cruz

研究领域

Microbial natural products are the unique compounds produced by fungi and bacteria. These compounds play important roles helping microorganisms adapt to their environment. Natural products exhibit a diverse array of novel structures and tend to be bioactive (e.g., function as enzyme inhibitors, cell signaling agents, toxins, and other roles), which makes these biomolecules an important resource for the development of new pharmaceuticals. Our lab focuses on using secondary metabolites from fungi and bacteria for the treatment of human diseases such as life-threatening infections and neurodegenerative disorders. By combining the exploration of new environmental niches (e.g., insects, Arctic soils, human body, and others) with novel techniques for controlling their production (e.g., chemical epigenetics), we are uncovering highly unusual metabolites with promising therapeutic applications. This approach has yielded many promising natural products and some of our compounds have entered into advanced preclinical testing. Our lab, the University of Oklahoma Natural Products Discovery Group, is actively recruiting new members to help in the search for novel drug leads. Prospective students in the areas of analytical and organic chemistry, as well as biochemistry are encouraged to contact us to find out more about current research opportunities.

近期论文

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Du, L.; King, J.B.; Cichewicz, R.H. Chlorinated Polyketide Obtained from a Daldinia sp. Treated with the Epigenetic Modifier Suberoylanilide Hydroxamic Acid. Journal of Natural Products, 2014, 77, (11), 2454-8. PMID:25338315. Wang, B.; You, J.; King, J.B.; Cai, S.; Park, E.; Powell, D.R.; Cichewicz, R.H. Polyketide Glycosides from Bionectria ochroleuca Inhibit Candida albicans Biofilm Formation. Journal of Natural Products, 2014, 77, (10), 2273-9. PMID 25302529. Cai, S.; King, J.B.; Du, L.; Powell, D.R.; Cichewicz, R.H. Bioactive Sulfur-Containing Sulochrin Dimers and Other Metabolites from an Alternaria sp. Isolate from a Hawaiian Soil Sample. Journal of Natural Products, 2014, 77, (10), 2280-7. PMID 25265160. Du, L.; Risinger, A. L., King, J.B.; Powell, D.R.; Cichewicz, R.H. A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells. Journal of Natural Products, 2014, 77, (7), 1753-7. PMID 24999749. Williams, R.B.; Du, L.; Norman, V. L.; Goering, M. G.; O’Neil-Johnson, M.; Woodbury, S.; Albrecht, M. A.; Powell, D. R.; Cichewicz, R. H.; Eldridge, G. R.; Starks, C. M. Diterpenes from the endangered goldenrod Solidago shortii. Journal of Natural Products, 2014, 77 (6), 1438-1444. PMID 24922615. Du, L.; Robles, A. J.; King, J. B.; Mooberry, S. L.; Cichewicz, R. H. Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. Journal of Natural Products, 2014, 77 (6), 1459-1466. PMID 24893224. Theodore, C.M.; Stamps, B.W.; King, J.B.; Price, L.S.; Powell, D.R.; Stevenson, B.S.; Cichewicz, R.H., Genomic and metabolomic insights into the natural product biosynthetic diversity of a feral-hog-associated Brevibacillus laterosporus strain. PLoS One 2014, 9, (3), e90124. Du, L.; Robles, A.J.; King, J.B.; Powell, D.R.; Miller, A.N.; Mooberry, S.L.; Cichewicz, R.H., Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Angewandte Chemie International Edition 2014, 53, (3), 804-9. Cai S., Du L.; Gerea A. L.; King J. B.; You J.; Cichewicz R. H., Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus. Organic Letters 2013, 15, (16), 4186-4189. Liu, X. H.; Miao, F. P.; Qiao, M. F.; Cichewicz, R. H.; Ji, N. Y., Terretonin, ophiobolin, and drimane terpenes with absolute configurations from an algicolous Aspergillus ustus. RSC Advances 2013, 3, (2), 588-595. You, J. L.; Du, L.; King, J. B.; Hall, B.E.; Cichewicz, R. H., Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates. ACS Chemical Biology 2013, 8, 840-848. Wang, X. R.; You, J. L.; King, J. B.; Powell, D. R.; Cichewicz, R. H., Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. Journal of Natural Products 2012, 75, (4), 707-715. Wang, X. R.; Du, L.; You, J. L.; King, J. B.; Cichewicz, R. H., Fungal biofilm inhibitors from a human oral microbiome-derived bacterium. Organic & Biomolecular Chemistry 2012, 10, (10), 2044-2050. Theodore, C. M.; King, J. B.; You, J. L.; Cichewicz, R. H., Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets. Journal of Natural Products 2012, 75, (11), 2007-2011. Miao, F.-P.; Li, X.-D.; Liu, X.-H.; Cichewicz, R. H.; Ji, N.-Y., Secondary metabolites from an algicolous Aspergillus versicolor strain. Marine Drugs 2012, 10, (1), 131-139. Jiang, M.; Wang, J.; Fu, J.; Du, L.; Jeong, H.; West, T.; Xiang, L.; Peng, Q.; Hou, Z.; Cai, H.; Seredenina, T.; Arbez, N.; Zhu, S.; Sommers, K.; Qian, J.; Zhang, J.; Mori, S.; Yang, X. W.; Tamashiro, K. L. K.; Aja, S.; Moran, T. H.; Luthi-Carter, R.; Martin, B.; Maudsley, S.; Mattson, M. P.; Cichewicz, R. H.; Ross, C. A.; Holtzman, D. M.; Krainc, D.; Duan, W., Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nature Medicine 2012, 18, (1), 153-158. Gerea, A. L.; Branscum, K. M.; King, J. B.; You, J.; Powell, D. R.; Miller, A. N.; Spear, J. R.; Cichewicz, R. H., Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring. Tetrahedron Letters 2012, 53, (32), 4202-4205. Fu, J.; Jin, J.; Cichewicz, R. H.; Hageman, S. A.; Ellis, T. K.; Xiang, L.; Peng, Q.; Jiang, M.; Arbez, N.; Hotaling, K.; Ross, C. A.; Duan, W., Trans-(−)-ϵ-viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington disease. Journal of Biological Chemistry 2012, 287, (29), 24460-24472. Du, L.; King, J. B.; Morrow, B. H.; Shen, J. K.; Miller, A. N.; Cichewicz, R. H., Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. Journal of Natural Products 2012, 75, (10), 1819-1823. Joyner, P. M.; Waters, A. L.; Williams, R. B.; Powell, D. R.; Janakiram, N. B.; Rao, C. V.; Cichewicz, R. H., Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells. Journal of Natural Products 2011, 74, (4), 857-861.